Mechanical design of DNA nanostructures

Structural DNA nanotechnology is a rapidly emerging field that has demonstrated great potential for applications such as single molecule sensing, drug delivery, and templating molecular components. As the applications of DNA nanotechnology expand, a consideration of their mechanical behavior is beco...

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Veröffentlicht in:Nanoscale 2015-01, Vol.7 (14), p.5913-5921
Hauptverfasser: Castro, Carlos E, Su, Hai-Jun, Marras, Alexander E, Zhou, Lifeng, Johnson, Joshua
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container_issue 14
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container_title Nanoscale
container_volume 7
creator Castro, Carlos E
Su, Hai-Jun
Marras, Alexander E
Zhou, Lifeng
Johnson, Joshua
description Structural DNA nanotechnology is a rapidly emerging field that has demonstrated great potential for applications such as single molecule sensing, drug delivery, and templating molecular components. As the applications of DNA nanotechnology expand, a consideration of their mechanical behavior is becoming essential to understand how these structures will respond to physical interactions. This review considers three major avenues of recent progress in this area: (1) measuring and designing mechanical properties of DNA nanostructures, (2) designing complex nanostructures based on imposed mechanical stresses, and (3) designing and controlling structurally dynamic nanostructures. This work has laid the foundation for mechanically active nanomachines that can generate, transmit, and respond to physical cues in molecular systems.
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source MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Deoxyribonucleic acid
Design engineering
DNA - chemistry
Dynamical systems
Dynamics
Foundations
Mechanical properties
Nanostructure
Nanostructures - chemistry
Nanotechnology
Nanotechnology - methods
title Mechanical design of DNA nanostructures
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