Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis
Purpose In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated. Methods Stem cell injections combined with arthroscopic lavage...
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| Veröffentlicht in: | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA sports traumatology, arthroscopy : official journal of the ESSKA, 2015-05, Vol.23 (5), p.1308-1316 |
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| container_title | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA |
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| creator | Koh, Yong-Gon Choi, Yun-Jin Kwon, Sae-Kwang Kim, Yong-Sang Yeo, Jee-Eun |
| description | Purpose
In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated.
Methods
Stem cell injections combined with arthroscopic lavage were administered to 30 elderly patients (≥65 years) with knee OA. Subcutaneous adipose tissue was harvested from both buttocks by liposuction. After stromal vascular fractions were isolated, a mean of 4.04 × 10
6
stem cells (9.7 % of 4.16 × 10
7
stromal vascular fraction cells) were prepared and injected in the selected knees of patients after arthroscopic lavage. Outcome measures included the Knee Injury and Osteoarthritis Outcome Scores, visual analog scale, and Lysholm score at preoperative and 3-, 12-, and 2-year follow-up visits. Sixteen patients underwent second-look arthroscopy.
Results
Almost all patients showed significant improvement in all clinical outcomes at the final follow-up examination. All clinical results significantly improved at 2-year follow-up compared to 12-month follow-up (
P
65 years, only five patients demonstrated worsening of Kellgren–Lawrence grade. On second-look arthroscopy, 87.5 % of elderly patients (14/16) improved or maintained cartilage status at least 2 years postoperatively. Moreover, none of the patients underwent total knee arthroplasty during this 2-year period.
Conclusion
Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function. Therefore, adipose-derived stem cell treatment appears to be a good option for OA treatment in elderly patients.
Level of evidence
Therapeutic case series study, Level IV. |
| doi_str_mv | 10.1007/s00167-013-2807-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1680444935</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1677372855</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-8217c431f965c5809852c20abcb07f9fbf2fb6d9a638861a66747c2593d13f773</originalsourceid><addsrcrecordid>eNqNkU1vFSEUhonR2Gv1B7gxJG7coHwNDEtzU2uTJm50PWGYQ0s7A1dgNG7622V6qzEmJq4gnOc8cHgResnoW0apflcoZUoTygThPdWEP0I7JoUgWkj9GO2okZxw2qkT9KyUG0rbVpqn6IRLwZXWZofu9nOIwdkZZyjrXAu2ccIFXIoTmVO6xTbX65yKS4fgsA9xCvGqUb5CxjWDrQvEir-Heo3tFA6pAJkgh2_QNBUW7GCeC_Yp49sIgFM7TPfOUEN5jp54Oxd48bCeoi8fzj7vP5LLT-cX-_eXxEndVdJzpp0UzBvVua6npu-449SObqTaGz967kc1GatE3ytmldJSO94ZMTHhtRan6M3Re8jp6wqlDkso28tshLSWgameSimN6P4DbT7N-25DX_-F3qQ1xzbIRikpjJasUexIufaNJYMfDjksNv8YGB22HIdjjkPLcdhyHHjrefVgXscFpt8dv4JrAD8CpZXiFeQ_rv6n9SfeuKkh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1676439741</pqid></control><display><type>article</type><title>Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Koh, Yong-Gon ; Choi, Yun-Jin ; Kwon, Sae-Kwang ; Kim, Yong-Sang ; Yeo, Jee-Eun</creator><creatorcontrib>Koh, Yong-Gon ; Choi, Yun-Jin ; Kwon, Sae-Kwang ; Kim, Yong-Sang ; Yeo, Jee-Eun</creatorcontrib><description>Purpose
In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated.
Methods
Stem cell injections combined with arthroscopic lavage were administered to 30 elderly patients (≥65 years) with knee OA. Subcutaneous adipose tissue was harvested from both buttocks by liposuction. After stromal vascular fractions were isolated, a mean of 4.04 × 10
6
stem cells (9.7 % of 4.16 × 10
7
stromal vascular fraction cells) were prepared and injected in the selected knees of patients after arthroscopic lavage. Outcome measures included the Knee Injury and Osteoarthritis Outcome Scores, visual analog scale, and Lysholm score at preoperative and 3-, 12-, and 2-year follow-up visits. Sixteen patients underwent second-look arthroscopy.
Results
Almost all patients showed significant improvement in all clinical outcomes at the final follow-up examination. All clinical results significantly improved at 2-year follow-up compared to 12-month follow-up (
P
< 0.05). Among elderly patients aged >65 years, only five patients demonstrated worsening of Kellgren–Lawrence grade. On second-look arthroscopy, 87.5 % of elderly patients (14/16) improved or maintained cartilage status at least 2 years postoperatively. Moreover, none of the patients underwent total knee arthroplasty during this 2-year period.
Conclusion
Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function. Therefore, adipose-derived stem cell treatment appears to be a good option for OA treatment in elderly patients.
Level of evidence
Therapeutic case series study, Level IV.</description><identifier>ISSN: 0942-2056</identifier><identifier>EISSN: 1433-7347</identifier><identifier>DOI: 10.1007/s00167-013-2807-2</identifier><identifier>PMID: 24326779</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arthritis ; Arthroplasty, Replacement, Knee ; Arthroscopy - methods ; Body fat ; Bone surgery ; Cartilage ; Cartilage - transplantation ; Clinical outcomes ; Female ; Follow-Up Studies ; Humans ; Injections, Intra-Articular ; Knee ; Knee Joint - pathology ; Knee Joint - physiopathology ; Knee Joint - surgery ; Lavage ; Liposuction ; Male ; Medicine ; Medicine & Public Health ; Mesenchymal Stem Cell Transplantation - methods ; Middle Aged ; Orthopedics ; Osteoarthritis ; Osteoarthritis, Knee - pathology ; Osteoarthritis, Knee - physiopathology ; Osteoarthritis, Knee - surgery ; Pain ; Range of Motion, Articular ; Second-Look Surgery - methods ; Stem cells ; Time Factors ; Transplantation, Autologous ; Treatment Outcome</subject><ispartof>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015-05, Vol.23 (5), p.1308-1316</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-8217c431f965c5809852c20abcb07f9fbf2fb6d9a638861a66747c2593d13f773</citedby><cites>FETCH-LOGICAL-c475t-8217c431f965c5809852c20abcb07f9fbf2fb6d9a638861a66747c2593d13f773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00167-013-2807-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00167-013-2807-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24326779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koh, Yong-Gon</creatorcontrib><creatorcontrib>Choi, Yun-Jin</creatorcontrib><creatorcontrib>Kwon, Sae-Kwang</creatorcontrib><creatorcontrib>Kim, Yong-Sang</creatorcontrib><creatorcontrib>Yeo, Jee-Eun</creatorcontrib><title>Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis</title><title>Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA</title><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><addtitle>Knee Surg Sports Traumatol Arthrosc</addtitle><description>Purpose
In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated.
Methods
Stem cell injections combined with arthroscopic lavage were administered to 30 elderly patients (≥65 years) with knee OA. Subcutaneous adipose tissue was harvested from both buttocks by liposuction. After stromal vascular fractions were isolated, a mean of 4.04 × 10
6
stem cells (9.7 % of 4.16 × 10
7
stromal vascular fraction cells) were prepared and injected in the selected knees of patients after arthroscopic lavage. Outcome measures included the Knee Injury and Osteoarthritis Outcome Scores, visual analog scale, and Lysholm score at preoperative and 3-, 12-, and 2-year follow-up visits. Sixteen patients underwent second-look arthroscopy.
Results
Almost all patients showed significant improvement in all clinical outcomes at the final follow-up examination. All clinical results significantly improved at 2-year follow-up compared to 12-month follow-up (
P
< 0.05). Among elderly patients aged >65 years, only five patients demonstrated worsening of Kellgren–Lawrence grade. On second-look arthroscopy, 87.5 % of elderly patients (14/16) improved or maintained cartilage status at least 2 years postoperatively. Moreover, none of the patients underwent total knee arthroplasty during this 2-year period.
Conclusion
Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function. Therefore, adipose-derived stem cell treatment appears to be a good option for OA treatment in elderly patients.
Level of evidence
Therapeutic case series study, Level IV.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis</subject><subject>Arthroplasty, Replacement, Knee</subject><subject>Arthroscopy - methods</subject><subject>Body fat</subject><subject>Bone surgery</subject><subject>Cartilage</subject><subject>Cartilage - transplantation</subject><subject>Clinical outcomes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Injections, Intra-Articular</subject><subject>Knee</subject><subject>Knee Joint - pathology</subject><subject>Knee Joint - physiopathology</subject><subject>Knee Joint - surgery</subject><subject>Lavage</subject><subject>Liposuction</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Osteoarthritis, Knee - surgery</subject><subject>Pain</subject><subject>Range of Motion, Articular</subject><subject>Second-Look Surgery - methods</subject><subject>Stem cells</subject><subject>Time Factors</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><issn>0942-2056</issn><issn>1433-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1vFSEUhonR2Gv1B7gxJG7coHwNDEtzU2uTJm50PWGYQ0s7A1dgNG7622V6qzEmJq4gnOc8cHgResnoW0apflcoZUoTygThPdWEP0I7JoUgWkj9GO2okZxw2qkT9KyUG0rbVpqn6IRLwZXWZofu9nOIwdkZZyjrXAu2ccIFXIoTmVO6xTbX65yKS4fgsA9xCvGqUb5CxjWDrQvEir-Heo3tFA6pAJkgh2_QNBUW7GCeC_Yp49sIgFM7TPfOUEN5jp54Oxd48bCeoi8fzj7vP5LLT-cX-_eXxEndVdJzpp0UzBvVua6npu-449SObqTaGz967kc1GatE3ytmldJSO94ZMTHhtRan6M3Re8jp6wqlDkso28tshLSWgameSimN6P4DbT7N-25DX_-F3qQ1xzbIRikpjJasUexIufaNJYMfDjksNv8YGB22HIdjjkPLcdhyHHjrefVgXscFpt8dv4JrAD8CpZXiFeQ_rv6n9SfeuKkh</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Koh, Yong-Gon</creator><creator>Choi, Yun-Jin</creator><creator>Kwon, Sae-Kwang</creator><creator>Kim, Yong-Sang</creator><creator>Yeo, Jee-Eun</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis</title><author>Koh, Yong-Gon ; 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In the present study, the clinical outcomes and second-look arthroscopic findings of intra-articular injection of stem cells with arthroscopic lavage for treatment of elderly patients with knee osteoarthritis (OA) were evaluated.
Methods
Stem cell injections combined with arthroscopic lavage were administered to 30 elderly patients (≥65 years) with knee OA. Subcutaneous adipose tissue was harvested from both buttocks by liposuction. After stromal vascular fractions were isolated, a mean of 4.04 × 10
6
stem cells (9.7 % of 4.16 × 10
7
stromal vascular fraction cells) were prepared and injected in the selected knees of patients after arthroscopic lavage. Outcome measures included the Knee Injury and Osteoarthritis Outcome Scores, visual analog scale, and Lysholm score at preoperative and 3-, 12-, and 2-year follow-up visits. Sixteen patients underwent second-look arthroscopy.
Results
Almost all patients showed significant improvement in all clinical outcomes at the final follow-up examination. All clinical results significantly improved at 2-year follow-up compared to 12-month follow-up (
P
< 0.05). Among elderly patients aged >65 years, only five patients demonstrated worsening of Kellgren–Lawrence grade. On second-look arthroscopy, 87.5 % of elderly patients (14/16) improved or maintained cartilage status at least 2 years postoperatively. Moreover, none of the patients underwent total knee arthroplasty during this 2-year period.
Conclusion
Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function. Therefore, adipose-derived stem cell treatment appears to be a good option for OA treatment in elderly patients.
Level of evidence
Therapeutic case series study, Level IV.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>24326779</pmid><doi>10.1007/s00167-013-2807-2</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0942-2056 |
| ispartof | Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2015-05, Vol.23 (5), p.1308-1316 |
| issn | 0942-2056 1433-7347 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Aged, 80 and over Arthritis Arthroplasty, Replacement, Knee Arthroscopy - methods Body fat Bone surgery Cartilage Cartilage - transplantation Clinical outcomes Female Follow-Up Studies Humans Injections, Intra-Articular Knee Knee Joint - pathology Knee Joint - physiopathology Knee Joint - surgery Lavage Liposuction Male Medicine Medicine & Public Health Mesenchymal Stem Cell Transplantation - methods Middle Aged Orthopedics Osteoarthritis Osteoarthritis, Knee - pathology Osteoarthritis, Knee - physiopathology Osteoarthritis, Knee - surgery Pain Range of Motion, Articular Second-Look Surgery - methods Stem cells Time Factors Transplantation, Autologous Treatment Outcome |
| title | Clinical results and second-look arthroscopic findings after treatment with adipose-derived stem cells for knee osteoarthritis |
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