Molecular epidemiology of tuberculosis in Cambodian children
We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian ge...
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| Veröffentlicht in: | Epidemiology and infection 2015-04, Vol.143 (5), p.910-921 |
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| creator | SCHOPFER, K. RIEDER, H. L. STEINLIN-SCHOPFER, J. F. van SOOLINGEN, D. BODMER, T. CHANTANA, Y. STUDER, P. LAURENT, D. ZWAHLEN, M. RICHNER, B. |
| description | We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian genotype family was the most common (59·0%), increasing in frequency with distance from the Phnom Penh area, while the frequency of the Beijing genotype family strains decreased. The drug resistance pattern showed a similar geographical gradient: lowest in the northwest (4·6%), intermediate in the central (17·1%), and highest in the southeastern (30·8%) parts of the country. Three children (1·9%) had multidrug-resistant tuberculosis. The Beijing genotype and streptomycin resistance were significantly associated (P |
| doi_str_mv | 10.1017/S0950268814001769 |
| format | Article |
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L. ; STEINLIN-SCHOPFER, J. F. ; van SOOLINGEN, D. ; BODMER, T. ; CHANTANA, Y. ; STUDER, P. ; LAURENT, D. ; ZWAHLEN, M. ; RICHNER, B.</creator><creatorcontrib>SCHOPFER, K. ; RIEDER, H. L. ; STEINLIN-SCHOPFER, J. F. ; van SOOLINGEN, D. ; BODMER, T. ; CHANTANA, Y. ; STUDER, P. ; LAURENT, D. ; ZWAHLEN, M. ; RICHNER, B.</creatorcontrib><description>We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian genotype family was the most common (59·0%), increasing in frequency with distance from the Phnom Penh area, while the frequency of the Beijing genotype family strains decreased. The drug resistance pattern showed a similar geographical gradient: lowest in the northwest (4·6%), intermediate in the central (17·1%), and highest in the southeastern (30·8%) parts of the country. Three children (1·9%) had multidrug-resistant tuberculosis. The Beijing genotype and streptomycin resistance were significantly associated (P < 0·001). As tuberculosis in children reflects recent transmission patterns in the community, multidrug resistance levels inform about the current quality of the tuberculosis programme.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268814001769</identifier><identifier>PMID: 25050615</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adolescent ; Antitubercular Agents - pharmacology ; Cambodia - epidemiology ; Child ; Child, Preschool ; DNA, Bacterial - analysis ; Drug Resistance, Multiple, Bacterial - genetics ; Epidemiology ; Female ; Genotype ; Genotype & phenotype ; Hospitals ; Humans ; Infant ; Infant, Newborn ; Isoniazid - pharmacology ; Laboratories ; Male ; Microbial Sensitivity Tests ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - drug effects ; Mycobacterium tuberculosis - genetics ; Original Papers ; Patients ; Pediatrics ; Rifampin - pharmacology ; Streptomycin - pharmacology ; Tuberculosis ; Tuberculosis - epidemiology ; Tuberculosis - microbiology ; Tuberculosis, Multidrug-Resistant - epidemiology ; Tuberculosis, Multidrug-Resistant - microbiology ; Tuberculosis/mycobacteria</subject><ispartof>Epidemiology and infection, 2015-04, Vol.143 (5), p.910-921</ispartof><rights>Copyright © Cambridge University Press 2014</rights><rights>Cambridge University Press 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-c44f3f4c8d97726fd6e30c0104c5305affc7eff968fa2bf8009f328cfce912c73</citedby><cites>FETCH-LOGICAL-c471t-c44f3f4c8d97726fd6e30c0104c5305affc7eff968fa2bf8009f328cfce912c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26512705$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26512705$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25050615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHOPFER, K.</creatorcontrib><creatorcontrib>RIEDER, H. L.</creatorcontrib><creatorcontrib>STEINLIN-SCHOPFER, J. F.</creatorcontrib><creatorcontrib>van SOOLINGEN, D.</creatorcontrib><creatorcontrib>BODMER, T.</creatorcontrib><creatorcontrib>CHANTANA, Y.</creatorcontrib><creatorcontrib>STUDER, P.</creatorcontrib><creatorcontrib>LAURENT, D.</creatorcontrib><creatorcontrib>ZWAHLEN, M.</creatorcontrib><creatorcontrib>RICHNER, B.</creatorcontrib><title>Molecular epidemiology of tuberculosis in Cambodian children</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian genotype family was the most common (59·0%), increasing in frequency with distance from the Phnom Penh area, while the frequency of the Beijing genotype family strains decreased. The drug resistance pattern showed a similar geographical gradient: lowest in the northwest (4·6%), intermediate in the central (17·1%), and highest in the southeastern (30·8%) parts of the country. Three children (1·9%) had multidrug-resistant tuberculosis. The Beijing genotype and streptomycin resistance were significantly associated (P < 0·001). As tuberculosis in children reflects recent transmission patterns in the community, multidrug resistance levels inform about the current quality of the tuberculosis programme.</description><subject>Adolescent</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Cambodia - epidemiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>DNA, Bacterial - analysis</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Isoniazid - pharmacology</subject><subject>Laboratories</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - drug effects</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Original Papers</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Rifampin - pharmacology</subject><subject>Streptomycin - pharmacology</subject><subject>Tuberculosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis, Multidrug-Resistant - epidemiology</subject><subject>Tuberculosis, Multidrug-Resistant - microbiology</subject><subject>Tuberculosis/mycobacteria</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkctKxDAUQIMozjj6AS6Ughs31ZtH0wTcyOALFBfqunTSZMzQNmPSLubvTZnxgSK4SQjn3EfuRegQwxkGnJ8_gcyAcCEwg_jmcguNMeMyZQzkNhoPOB34CO2FsAAASUS-i0Ykgww4zsbo4sHVWvV16RO9tJVurKvdfJU4k3T9TPuIXLAhsW0yLZuZq2zZJurV1pXX7T7aMWUd9MHmnqCX66vn6W16_3hzN728TxXLcRdPZqhhSlQyzwk3FdcUFGBgKqOQlcaoXBsjuTAlmRkR2zSUCGWUlpionE7Q6Trv0ru3XoeuaGxQuq7LVrs-FJgLYIxlhP9D5ZhSDBSievJDXbjet_EjgwWSc4FFtPDaUt6F4LUplt42pV8VGIphC8WvLcSY403mftbo6jPiY-xROFoLi9A5_8V5hkkOA6ebonHm3lZz_a23P8u-AxjgmWQ</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>SCHOPFER, K.</creator><creator>RIEDER, H. 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L.</au><au>STEINLIN-SCHOPFER, J. F.</au><au>van SOOLINGEN, D.</au><au>BODMER, T.</au><au>CHANTANA, Y.</au><au>STUDER, P.</au><au>LAURENT, D.</au><au>ZWAHLEN, M.</au><au>RICHNER, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular epidemiology of tuberculosis in Cambodian children</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>143</volume><issue>5</issue><spage>910</spage><epage>921</epage><pages>910-921</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><abstract>We analysed Mycobacterium tuberculosis strains from children, hospitalized from January 2004 to July 2008 in the largest paediatric hospital complex in Cambodia. Specimens were tested for drug susceptibility and genotypes. From the 260 children, 161 strains were available. The East African-Indian genotype family was the most common (59·0%), increasing in frequency with distance from the Phnom Penh area, while the frequency of the Beijing genotype family strains decreased. The drug resistance pattern showed a similar geographical gradient: lowest in the northwest (4·6%), intermediate in the central (17·1%), and highest in the southeastern (30·8%) parts of the country. Three children (1·9%) had multidrug-resistant tuberculosis. The Beijing genotype and streptomycin resistance were significantly associated (P < 0·001). As tuberculosis in children reflects recent transmission patterns in the community, multidrug resistance levels inform about the current quality of the tuberculosis programme.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>25050615</pmid><doi>10.1017/S0950268814001769</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Antitubercular Agents - pharmacology Cambodia - epidemiology Child Child, Preschool DNA, Bacterial - analysis Drug Resistance, Multiple, Bacterial - genetics Epidemiology Female Genotype Genotype & phenotype Hospitals Humans Infant Infant, Newborn Isoniazid - pharmacology Laboratories Male Microbial Sensitivity Tests Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Original Papers Patients Pediatrics Rifampin - pharmacology Streptomycin - pharmacology Tuberculosis Tuberculosis - epidemiology Tuberculosis - microbiology Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - microbiology Tuberculosis/mycobacteria |
| title | Molecular epidemiology of tuberculosis in Cambodian children |
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