Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy

Dietary conjugated linoleic acid (CLA) reduces indicators of early renal disease progression and the associated elevated cyclooxygenase (COX) levels in young obese rats with obesity-associated nephropathy (OAN). Therefore, renal function and injury and COX and its metabolites were assessed in obese...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2015-02, Vol.26 (2), p.130-137
Hauptverfasser:	Zhan, Yang, Shi, Hong, Caligiuri, Stephanie P.B., Wu, Yinghong, Declercq, Vanessa, Taylor, Carla G., Zahradka, Peter, Ogborn, Malcolm R., Aukema, Harold M.
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Ketoprostaglandin F1 alpha - agonists 6-Ketoprostaglandin F1 alpha - antagonists & inhibitors 6-Ketoprostaglandin F1 alpha - metabolism Aging Animals Conjugated linoleic acid isomers COX Cyclooxygenase 1 - metabolism Dietary Supplements - adverse effects Disease Progression Fibrosis Hypertrophy Kidney - immunology Kidney - metabolism Kidney - pathology Kidney - physiopathology Linoleic Acids, Conjugated - adverse effects Macrophage Activation Membrane Proteins - agonists Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Obesity Obesity - immunology Obesity - physiopathology Oxylipins Oxylipins - agonists Oxylipins - antagonists & inhibitors Oxylipins - metabolism Rats, Zucker Renal Insufficiency - etiology Renal Insufficiency - metabolism Renal Insufficiency - pathology Renal Insufficiency - physiopathology Severity of Illness Index Thromboxane B2 - agonists Thromboxane B2 - antagonists & inhibitors Thromboxane B2 - metabolism
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