Acute effects of plant stanol esters on postprandial metabolism and its relation with changes in serum lipids after chronic intake
Background/objectives: Plant stanol esters lower serum low-density lipoprotein (LDL)-cholesterol (LDL-C), but responses between individuals vary widely. As the ability of subjects to respond to acute dietary challenges may reflect the flexibility to adapt to changes on the longer term, we related su...
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| Veröffentlicht in: | European journal of clinical nutrition 2015-01, Vol.69 (1), p.127-133 |
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| creator | De Smet, E Mensink, R P Lütjohann, D Plat, J |
| description | Background/objectives:
Plant stanol esters lower serum low-density lipoprotein (LDL)-cholesterol (LDL-C), but responses between individuals vary widely. As the ability of subjects to respond to acute dietary challenges may reflect the flexibility to adapt to changes on the longer term, we related subjects' acute postprandial metabolic changes to changes in serum lipoproteins after chronic intake of plant stanol esters.
Subjects/methods:
In a double-blind crossover design, 20 healthy subjects received in random order a high-fat shake enriched with or without plant stanol esters (4 g). Blood samples were taken during 4 h to examine lipid, glucose and lipoprotein profiles. Two subjects dropped out. For the 3 weeks after this postprandial test, the subjects who received the shake with plant stanol esters continued the consumption of plant stanol-enriched (3g/day) margarine and subjects receiving the control shake in the postprandial test consumed for the next 3 weeks a control margarine. After the washout period, subjects received the other shake and margarines.
Results:
The margarine enriched with plant stanol esters lowered concentrations of total cholesterol by 7.3% (
P |
| doi_str_mv | 10.1038/ejcn.2014.200 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1680443806</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A396615760</galeid><sourcerecordid>A396615760</sourcerecordid><originalsourceid>FETCH-LOGICAL-c596t-8931d3ba2e742c3a69cc8a1a0fc1ae32c66a6da83d5e653764f73db3564219643</originalsourceid><addsrcrecordid>eNp9kt-L1DAQx4so3nr66KsEBPGla9K0Sfu4HP6CA1_0ucym092saVKTlMNX_3KneHqnLBKYwMxnJjOTb1E8F3wruGzf4Mn4bcVFTYY_KDai1qpsVM0fFhveNXUpOdcXxZOUTpworavHxUXVVFpw0WyKHzuzZGQ4jmhyYmFkswOfWcrgg2OYMkZyezaHlOcIfrDg2IQZ9sHZNDHyMEuZER1kS-CNzUdmjuAPmJj1LGFcJubsbIfEYKR6FI3BW0PRDF_xafFoBJfw2e19WXx59_bz1Yfy-tP7j1e769I0ncpl20kxyD1UqOvKSFCdMS0I4KMRgLIySoEaoJVDg6qRWtWjlsNe0i4q0alaXhavf9WdY_i20GT9ZJNBR_NiWFIvVMvrWrZcEfryH_QUluipu76SUtB2RSf_RxFSKamlbu6oAzjsrR9DjmDWp_ud7JQSjVacqPIMdUCPEVzwOFpy_8Vvz_B0BpysOZvw6l7CEcHlYwpuWf8sne3ExJBSxLGfo50gfu8F71fJ9avk-lVyZFb-xe0Wlv2Ewx_6t8buWk0UIlXEe2s6W_EnkdTefw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1642637375</pqid></control><display><type>article</type><title>Acute effects of plant stanol esters on postprandial metabolism and its relation with changes in serum lipids after chronic intake</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>De Smet, E ; Mensink, R P ; Lütjohann, D ; Plat, J</creator><creatorcontrib>De Smet, E ; Mensink, R P ; Lütjohann, D ; Plat, J</creatorcontrib><description>Background/objectives:
Plant stanol esters lower serum low-density lipoprotein (LDL)-cholesterol (LDL-C), but responses between individuals vary widely. As the ability of subjects to respond to acute dietary challenges may reflect the flexibility to adapt to changes on the longer term, we related subjects' acute postprandial metabolic changes to changes in serum lipoproteins after chronic intake of plant stanol esters.
Subjects/methods:
In a double-blind crossover design, 20 healthy subjects received in random order a high-fat shake enriched with or without plant stanol esters (4 g). Blood samples were taken during 4 h to examine lipid, glucose and lipoprotein profiles. Two subjects dropped out. For the 3 weeks after this postprandial test, the subjects who received the shake with plant stanol esters continued the consumption of plant stanol-enriched (3g/day) margarine and subjects receiving the control shake in the postprandial test consumed for the next 3 weeks a control margarine. After the washout period, subjects received the other shake and margarines.
Results:
The margarine enriched with plant stanol esters lowered concentrations of total cholesterol by 7.3% (
P
<0.01), LDL-C by 9.5% (
P
<0.01) and apoB100 by 8.6% (
P
<0.01). Furthermore, particle concentrations of total very low-density lipoprotein (VLDL), small VLDL and large LDL were reduced by 26.6% (
P
=0.02), 27.6% (
P
=0.02) and 12.3% (
P
=0.04), respectively. Plant stanol esters did not affect parameters related to lipid and glucose metabolism during the postprandial phase. However, the incremental area under the curve (iAUC) of the postprandial glucose concentration after consuming the control shake correlated positively with changes in fasting concentrations of total cholesterol, LDL-C, apoB100, total VLDL, small VLDL and intermediate-density lipoprotein after 3 weeks.
Conclusions:
A single dose of plant stanol esters does not change postprandial lipid and lipoprotein profiles. However, postprandial glucose responses may predict the effects of chronic plant stanol ester consumption.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2014.200</identifier><identifier>PMID: 25271015</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/443/319 ; 692/699/317 ; 692/700/2814 ; 82/58 ; Acute effects ; Adult ; Blood ; Blood Glucose - analysis ; Cholesterol ; Cholesterol, LDL ; Clinical Nutrition ; Consumption ; Cross-Over Studies ; Crossovers ; Density ; Diet ; Double-Blind Method ; Enrichment ; Epidemiology ; Esters ; Female ; Food, Fortified ; Glucose ; Glucose metabolism ; Health aspects ; Humans ; Internal Medicine ; Lipid metabolism ; Lipid Metabolism - drug effects ; Lipids ; Lipids - blood ; Lipoproteins ; Lipoproteins (very low density) ; Lipoproteins - blood ; Low density lipoprotein ; Male ; Margarine ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Nutrition research ; original-article ; Phytochemicals ; Postprandial Period ; Protein research ; Public Health ; Serum lipids ; Sitosterols - administration & dosage ; Young Adult</subject><ispartof>European journal of clinical nutrition, 2015-01, Vol.69 (1), p.127-133</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c596t-8931d3ba2e742c3a69cc8a1a0fc1ae32c66a6da83d5e653764f73db3564219643</citedby><cites>FETCH-LOGICAL-c596t-8931d3ba2e742c3a69cc8a1a0fc1ae32c66a6da83d5e653764f73db3564219643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ejcn.2014.200$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ejcn.2014.200$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25271015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Smet, E</creatorcontrib><creatorcontrib>Mensink, R P</creatorcontrib><creatorcontrib>Lütjohann, D</creatorcontrib><creatorcontrib>Plat, J</creatorcontrib><title>Acute effects of plant stanol esters on postprandial metabolism and its relation with changes in serum lipids after chronic intake</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/objectives:
Plant stanol esters lower serum low-density lipoprotein (LDL)-cholesterol (LDL-C), but responses between individuals vary widely. As the ability of subjects to respond to acute dietary challenges may reflect the flexibility to adapt to changes on the longer term, we related subjects' acute postprandial metabolic changes to changes in serum lipoproteins after chronic intake of plant stanol esters.
Subjects/methods:
In a double-blind crossover design, 20 healthy subjects received in random order a high-fat shake enriched with or without plant stanol esters (4 g). Blood samples were taken during 4 h to examine lipid, glucose and lipoprotein profiles. Two subjects dropped out. For the 3 weeks after this postprandial test, the subjects who received the shake with plant stanol esters continued the consumption of plant stanol-enriched (3g/day) margarine and subjects receiving the control shake in the postprandial test consumed for the next 3 weeks a control margarine. After the washout period, subjects received the other shake and margarines.
Results:
The margarine enriched with plant stanol esters lowered concentrations of total cholesterol by 7.3% (
P
<0.01), LDL-C by 9.5% (
P
<0.01) and apoB100 by 8.6% (
P
<0.01). Furthermore, particle concentrations of total very low-density lipoprotein (VLDL), small VLDL and large LDL were reduced by 26.6% (
P
=0.02), 27.6% (
P
=0.02) and 12.3% (
P
=0.04), respectively. Plant stanol esters did not affect parameters related to lipid and glucose metabolism during the postprandial phase. However, the incremental area under the curve (iAUC) of the postprandial glucose concentration after consuming the control shake correlated positively with changes in fasting concentrations of total cholesterol, LDL-C, apoB100, total VLDL, small VLDL and intermediate-density lipoprotein after 3 weeks.
Conclusions:
A single dose of plant stanol esters does not change postprandial lipid and lipoprotein profiles. However, postprandial glucose responses may predict the effects of chronic plant stanol ester consumption.</description><subject>59/57</subject><subject>631/443/319</subject><subject>692/699/317</subject><subject>692/700/2814</subject><subject>82/58</subject><subject>Acute effects</subject><subject>Adult</subject><subject>Blood</subject><subject>Blood Glucose - analysis</subject><subject>Cholesterol</subject><subject>Cholesterol, LDL</subject><subject>Clinical Nutrition</subject><subject>Consumption</subject><subject>Cross-Over Studies</subject><subject>Crossovers</subject><subject>Density</subject><subject>Diet</subject><subject>Double-Blind Method</subject><subject>Enrichment</subject><subject>Epidemiology</subject><subject>Esters</subject><subject>Female</subject><subject>Food, Fortified</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lipid metabolism</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoproteins</subject><subject>Lipoproteins (very low density)</subject><subject>Lipoproteins - blood</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Margarine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>original-article</subject><subject>Phytochemicals</subject><subject>Postprandial Period</subject><subject>Protein research</subject><subject>Public Health</subject><subject>Serum lipids</subject><subject>Sitosterols - administration & dosage</subject><subject>Young Adult</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kt-L1DAQx4so3nr66KsEBPGla9K0Sfu4HP6CA1_0ucym092saVKTlMNX_3KneHqnLBKYwMxnJjOTb1E8F3wruGzf4Mn4bcVFTYY_KDai1qpsVM0fFhveNXUpOdcXxZOUTpworavHxUXVVFpw0WyKHzuzZGQ4jmhyYmFkswOfWcrgg2OYMkZyezaHlOcIfrDg2IQZ9sHZNDHyMEuZER1kS-CNzUdmjuAPmJj1LGFcJubsbIfEYKR6FI3BW0PRDF_xafFoBJfw2e19WXx59_bz1Yfy-tP7j1e769I0ncpl20kxyD1UqOvKSFCdMS0I4KMRgLIySoEaoJVDg6qRWtWjlsNe0i4q0alaXhavf9WdY_i20GT9ZJNBR_NiWFIvVMvrWrZcEfryH_QUluipu76SUtB2RSf_RxFSKamlbu6oAzjsrR9DjmDWp_ud7JQSjVacqPIMdUCPEVzwOFpy_8Vvz_B0BpysOZvw6l7CEcHlYwpuWf8sne3ExJBSxLGfo50gfu8F71fJ9avk-lVyZFb-xe0Wlv2Ewx_6t8buWk0UIlXEe2s6W_EnkdTefw</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>De Smet, E</creator><creator>Mensink, R P</creator><creator>Lütjohann, D</creator><creator>Plat, J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20150101</creationdate><title>Acute effects of plant stanol esters on postprandial metabolism and its relation with changes in serum lipids after chronic intake</title><author>De Smet, E ; Mensink, R P ; Lütjohann, D ; Plat, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c596t-8931d3ba2e742c3a69cc8a1a0fc1ae32c66a6da83d5e653764f73db3564219643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>59/57</topic><topic>631/443/319</topic><topic>692/699/317</topic><topic>692/700/2814</topic><topic>82/58</topic><topic>Acute effects</topic><topic>Adult</topic><topic>Blood</topic><topic>Blood Glucose - analysis</topic><topic>Cholesterol</topic><topic>Cholesterol, LDL</topic><topic>Clinical Nutrition</topic><topic>Consumption</topic><topic>Cross-Over Studies</topic><topic>Crossovers</topic><topic>Density</topic><topic>Diet</topic><topic>Double-Blind Method</topic><topic>Enrichment</topic><topic>Epidemiology</topic><topic>Esters</topic><topic>Female</topic><topic>Food, Fortified</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lipid metabolism</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipoproteins</topic><topic>Lipoproteins (very low density)</topic><topic>Lipoproteins - blood</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Margarine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Nutrition research</topic><topic>original-article</topic><topic>Phytochemicals</topic><topic>Postprandial Period</topic><topic>Protein research</topic><topic>Public Health</topic><topic>Serum lipids</topic><topic>Sitosterols - administration & dosage</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Smet, E</creatorcontrib><creatorcontrib>Mensink, R P</creatorcontrib><creatorcontrib>Lütjohann, D</creatorcontrib><creatorcontrib>Plat, J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Smet, E</au><au>Mensink, R P</au><au>Lütjohann, D</au><au>Plat, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute effects of plant stanol esters on postprandial metabolism and its relation with changes in serum lipids after chronic intake</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>69</volume><issue>1</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/objectives:
Plant stanol esters lower serum low-density lipoprotein (LDL)-cholesterol (LDL-C), but responses between individuals vary widely. As the ability of subjects to respond to acute dietary challenges may reflect the flexibility to adapt to changes on the longer term, we related subjects' acute postprandial metabolic changes to changes in serum lipoproteins after chronic intake of plant stanol esters.
Subjects/methods:
In a double-blind crossover design, 20 healthy subjects received in random order a high-fat shake enriched with or without plant stanol esters (4 g). Blood samples were taken during 4 h to examine lipid, glucose and lipoprotein profiles. Two subjects dropped out. For the 3 weeks after this postprandial test, the subjects who received the shake with plant stanol esters continued the consumption of plant stanol-enriched (3g/day) margarine and subjects receiving the control shake in the postprandial test consumed for the next 3 weeks a control margarine. After the washout period, subjects received the other shake and margarines.
Results:
The margarine enriched with plant stanol esters lowered concentrations of total cholesterol by 7.3% (
P
<0.01), LDL-C by 9.5% (
P
<0.01) and apoB100 by 8.6% (
P
<0.01). Furthermore, particle concentrations of total very low-density lipoprotein (VLDL), small VLDL and large LDL were reduced by 26.6% (
P
=0.02), 27.6% (
P
=0.02) and 12.3% (
P
=0.04), respectively. Plant stanol esters did not affect parameters related to lipid and glucose metabolism during the postprandial phase. However, the incremental area under the curve (iAUC) of the postprandial glucose concentration after consuming the control shake correlated positively with changes in fasting concentrations of total cholesterol, LDL-C, apoB100, total VLDL, small VLDL and intermediate-density lipoprotein after 3 weeks.
Conclusions:
A single dose of plant stanol esters does not change postprandial lipid and lipoprotein profiles. However, postprandial glucose responses may predict the effects of chronic plant stanol ester consumption.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25271015</pmid><doi>10.1038/ejcn.2014.200</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of clinical nutrition, 2015-01, Vol.69 (1), p.127-133 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1680443806 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 59/57 631/443/319 692/699/317 692/700/2814 82/58 Acute effects Adult Blood Blood Glucose - analysis Cholesterol Cholesterol, LDL Clinical Nutrition Consumption Cross-Over Studies Crossovers Density Diet Double-Blind Method Enrichment Epidemiology Esters Female Food, Fortified Glucose Glucose metabolism Health aspects Humans Internal Medicine Lipid metabolism Lipid Metabolism - drug effects Lipids Lipids - blood Lipoproteins Lipoproteins (very low density) Lipoproteins - blood Low density lipoprotein Male Margarine Medicine Medicine & Public Health Metabolic Diseases Metabolism Nutrition research original-article Phytochemicals Postprandial Period Protein research Public Health Serum lipids Sitosterols - administration & dosage Young Adult |
| title | Acute effects of plant stanol esters on postprandial metabolism and its relation with changes in serum lipids after chronic intake |
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