Tumor necrosis factor alpha stimulates p62 accumulation and enhances proteasome activity independently of ROS

Circulating TNF-α levels are elevated in a wide variety of cardiovascular pathologies including congestive heart failure (CHF). This cytokine is one of the leading mediators of the immune inflammatory response with widespread biological functions regulated by membrane receptors. The pathophysiologic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell biology and toxicology 2015-04, Vol.31 (2), p.83-94
Hauptverfasser:	Opperman, Caleigh M., Sishi, Balindiwe J. N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Animal diseases Animals Autophagy Biochemistry Biomedical and Life Sciences Cell Biology Cell Line Cell Survival - drug effects Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Gene Expression Regulation Heat-Shock Proteins - agonists Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Life Sciences Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Mitochondria - drug effects Mitochondria - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Original Research Pharmacology/Toxicology Proteases Proteasome Endopeptidase Complex - drug effects Proteasome Endopeptidase Complex - metabolism Proteolysis - drug effects Rats Reactive Oxygen Species - metabolism Sequestosome-1 Protein Signal Transduction SKP Cullin F-Box Protein Ligases - genetics SKP Cullin F-Box Protein Ligases - metabolism TNF inhibitors Tripartite Motif Proteins Tumor Necrosis Factor-alpha - pharmacology Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!