Insulin Up-Regulates Natriuretic Peptide Clearance Receptor Expression in the Subcutaneous Fat Depot in Obese Subjects: A Missing Link between CVD Risk and Obesity?

Context: Natriuretic peptides (NP) regulate cardiovascular homeostasis and have multiple metabolic properties. Decreased levels of NP or “natriuretic handicap” are signs of insulin resistance such as central obesity. Increased expression of NP clearance receptor (NPRC) in sc adipose tissue (SAT) was...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2012-05, Vol.97 (5), p.E731-E739
Hauptverfasser:	Pivovarova, Olga, Gögebakan, Özlem, Klöting, Nora, Sparwasser, Andrea, Weickert, Martin O, Haddad, Isam, Nikiforova, Victoria J, Bergmann, Andreas, Kruse, Michael, Seltmann, Anne-Cathrin, Blüher, Matthias, Pfeiffer, Andreas F. H, Rudovich, Natalia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood glucose Blood Glucose - metabolism Cardiorespiratory Culture Diabetes Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Fats Female Gene Expression - drug effects Gene Expression - physiology Hormones Humans Insulin - metabolism Insulin - pharmacology Insulin Resistance Intra-Abdominal Fat - drug effects Intra-Abdominal Fat - metabolism Male Measurement Obesity Obesity - genetics Obesity - metabolism Receptors, Atrial Natriuretic Factor - genetics Receptors, Atrial Natriuretic Factor - metabolism Subcutaneous Fat - drug effects Subcutaneous Fat - metabolism
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