Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes
The naturally antioxidant and coenzyme, alpha-lipoic acid (α-LA), has gained considerable attention regarding different functions and therapeutically effective in treating oxidative stress-associated diseases in the human body. This study was designed to examine the protective effect of α-LA against...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 2015-05, Vol.403 (1-2), p.179-186 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 186 |
|---|---|
| container_issue | 1-2 |
| container_start_page | 179 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 403 |
| creator | Rahimifard, Mahban Navaei-Nigjeh, Mona Baeeri, Maryam Maqbool, Faheem Abdollahi, Mohammad |
| description | The naturally antioxidant and coenzyme, alpha-lipoic acid (α-LA), has gained considerable attention regarding different functions and therapeutically effective in treating oxidative stress-associated diseases in the human body. This study was designed to examine the protective effect of α-LA against H
2
O
2
-induced oxidative stress and apoptosis in human lymphoid cells. Human peripheral blood lymphocytes were preincubated with α-LA and then exposed to H
2
O
2
. After that, the viability of the cells, rate of apoptosis, oxidative stress biomarkers such as reactive oxygen species (ROS) and level of lipid peroxidation (LPO), and also tumor necrosis factor-α (TNF-α) were studied. Pretreatment of lymphocytes with α-LA, dramatically enhanced viability of the cells and decreased apoptosis. Investigation of caspases gives a clear picture of the mechanism by which α-LA decreases ROS and causes a reduction in apoptosis through caspase-9-dependent mitochondrial pathway. Furthermore, α-LA dose dependently decreased oxidative stress by a reduction in level of LPO, and the dose of 1000 µM indicates a significant decrease (
p
|
| doi_str_mv | 10.1007/s11010-015-2348-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1680434994</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A430343221</galeid><sourcerecordid>A430343221</sourcerecordid><originalsourceid>FETCH-LOGICAL-c542t-111a8c9b3c858b9132c2e15fa37edd6e3eb81fc99f3d9db642053ff4e6477efb3</originalsourceid><addsrcrecordid>eNp1kstu1TAQhiMEoofCA7BBltiwIMUTOxcvq4qbVMQG1pZjj09cJXaIHUTehYfF4ZSrQF5Ynvn-X-PRXxSPgV4Ape2LCECBlhTqsmK8K7s7xQHqlpVcgLhbHCijtOygbc-KBzHe0AxTgPvFWVU3Latpdyi-vlvH5OYRybyEhDq5z0gm1IPyLk6RBEvUOA-qHN0cnCZKO0OcJ-GLMyq54J8TNYc5hegiUX7v2VFN0_ceUUflfExk2MwSjujJjMuuxIyZVaMhKT-1S9vuOayT8mTcpnkIeksYHxb3rBojPrq9z4uPr15-uHpTXr9__fbq8rrUNa9SCQCq06Jnuqu7XgCrdIVQW8VaNKZBhn0HVgthmRGmb3hFa2Ytx4a3LdqenRfPTr55B59WjElOLmocR-UxrFFC01HOuBA8o0__Qm_Cuvg8XaYawaFtmPhFHdWIMq8kpEXp3VReckYZZ1UFmbr4B5WPwcnp4NG6XP9DACeBXkKMC1o5L25SyyaByj0R8pQImRMh90TILmue3A689hOan4ofEchAdQJibvkjLr_96L-u3wAPIMMv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1669417639</pqid></control><display><type>article</type><title>Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Rahimifard, Mahban ; Navaei-Nigjeh, Mona ; Baeeri, Maryam ; Maqbool, Faheem ; Abdollahi, Mohammad</creator><creatorcontrib>Rahimifard, Mahban ; Navaei-Nigjeh, Mona ; Baeeri, Maryam ; Maqbool, Faheem ; Abdollahi, Mohammad</creatorcontrib><description>The naturally antioxidant and coenzyme, alpha-lipoic acid (α-LA), has gained considerable attention regarding different functions and therapeutically effective in treating oxidative stress-associated diseases in the human body. This study was designed to examine the protective effect of α-LA against H
2
O
2
-induced oxidative stress and apoptosis in human lymphoid cells. Human peripheral blood lymphocytes were preincubated with α-LA and then exposed to H
2
O
2
. After that, the viability of the cells, rate of apoptosis, oxidative stress biomarkers such as reactive oxygen species (ROS) and level of lipid peroxidation (LPO), and also tumor necrosis factor-α (TNF-α) were studied. Pretreatment of lymphocytes with α-LA, dramatically enhanced viability of the cells and decreased apoptosis. Investigation of caspases gives a clear picture of the mechanism by which α-LA decreases ROS and causes a reduction in apoptosis through caspase-9-dependent mitochondrial pathway. Furthermore, α-LA dose dependently decreased oxidative stress by a reduction in level of LPO, and the dose of 1000 µM indicates a significant decrease (
p
< 0.01) in TNF-α level. Collectively, the present data show that α-LA is an ideal compound which has profound protective effects on oxidation, inflammation, and apoptosis. As a result, α-LA may indicate a new way toward the development of antioxidant therapy.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/s11010-015-2348-8</identifier><identifier>PMID: 25673508</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Acids ; Antioxidants ; Antioxidants (Nutrients) ; Apoptosis ; Apoptosis - drug effects ; Biochemistry ; Biomedical and Life Sciences ; Cardiology ; Caspase 3 - metabolism ; Caspase 9 - metabolism ; Cell Survival - drug effects ; Enzymes ; Flow Cytometry ; Fluorescence ; Humans ; Hydrogen peroxide ; Hydrogen Peroxide - toxicity ; Inflammation ; Inflammation - pathology ; Life Sciences ; Lipid peroxidation ; Lymphocytes ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; Lymphocytes - pathology ; Medical Biochemistry ; Mitochondria - drug effects ; Mitochondria - metabolism ; Oncology ; Oxidation ; Oxidation-Reduction - drug effects ; Oxidative stress ; Oxidative Stress - drug effects ; Peroxidation ; Protective Agents - pharmacology ; Staining and Labeling ; Thioctic Acid - pharmacology ; Toxicity ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Molecular and cellular biochemistry, 2015-05, Vol.403 (1-2), p.179-186</ispartof><rights>Springer Science+Business Media New York 2015</rights><rights>COPYRIGHT 2015 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-111a8c9b3c858b9132c2e15fa37edd6e3eb81fc99f3d9db642053ff4e6477efb3</citedby><cites>FETCH-LOGICAL-c542t-111a8c9b3c858b9132c2e15fa37edd6e3eb81fc99f3d9db642053ff4e6477efb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11010-015-2348-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11010-015-2348-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25673508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahimifard, Mahban</creatorcontrib><creatorcontrib>Navaei-Nigjeh, Mona</creatorcontrib><creatorcontrib>Baeeri, Maryam</creatorcontrib><creatorcontrib>Maqbool, Faheem</creatorcontrib><creatorcontrib>Abdollahi, Mohammad</creatorcontrib><title>Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><addtitle>Mol Cell Biochem</addtitle><description>The naturally antioxidant and coenzyme, alpha-lipoic acid (α-LA), has gained considerable attention regarding different functions and therapeutically effective in treating oxidative stress-associated diseases in the human body. This study was designed to examine the protective effect of α-LA against H
2
O
2
-induced oxidative stress and apoptosis in human lymphoid cells. Human peripheral blood lymphocytes were preincubated with α-LA and then exposed to H
2
O
2
. After that, the viability of the cells, rate of apoptosis, oxidative stress biomarkers such as reactive oxygen species (ROS) and level of lipid peroxidation (LPO), and also tumor necrosis factor-α (TNF-α) were studied. Pretreatment of lymphocytes with α-LA, dramatically enhanced viability of the cells and decreased apoptosis. Investigation of caspases gives a clear picture of the mechanism by which α-LA decreases ROS and causes a reduction in apoptosis through caspase-9-dependent mitochondrial pathway. Furthermore, α-LA dose dependently decreased oxidative stress by a reduction in level of LPO, and the dose of 1000 µM indicates a significant decrease (
p
< 0.01) in TNF-α level. Collectively, the present data show that α-LA is an ideal compound which has profound protective effects on oxidation, inflammation, and apoptosis. As a result, α-LA may indicate a new way toward the development of antioxidant therapy.</description><subject>Acids</subject><subject>Antioxidants</subject><subject>Antioxidants (Nutrients)</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cardiology</subject><subject>Caspase 3 - metabolism</subject><subject>Caspase 9 - metabolism</subject><subject>Cell Survival - drug effects</subject><subject>Enzymes</subject><subject>Flow Cytometry</subject><subject>Fluorescence</subject><subject>Humans</subject><subject>Hydrogen peroxide</subject><subject>Hydrogen Peroxide - toxicity</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>Life Sciences</subject><subject>Lipid peroxidation</subject><subject>Lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - metabolism</subject><subject>Lymphocytes - pathology</subject><subject>Medical Biochemistry</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Oncology</subject><subject>Oxidation</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Peroxidation</subject><subject>Protective Agents - pharmacology</subject><subject>Staining and Labeling</subject><subject>Thioctic Acid - pharmacology</subject><subject>Toxicity</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kstu1TAQhiMEoofCA7BBltiwIMUTOxcvq4qbVMQG1pZjj09cJXaIHUTehYfF4ZSrQF5Ynvn-X-PRXxSPgV4Ape2LCECBlhTqsmK8K7s7xQHqlpVcgLhbHCijtOygbc-KBzHe0AxTgPvFWVU3Latpdyi-vlvH5OYRybyEhDq5z0gm1IPyLk6RBEvUOA-qHN0cnCZKO0OcJ-GLMyq54J8TNYc5hegiUX7v2VFN0_ceUUflfExk2MwSjujJjMuuxIyZVaMhKT-1S9vuOayT8mTcpnkIeksYHxb3rBojPrq9z4uPr15-uHpTXr9__fbq8rrUNa9SCQCq06Jnuqu7XgCrdIVQW8VaNKZBhn0HVgthmRGmb3hFa2Ytx4a3LdqenRfPTr55B59WjElOLmocR-UxrFFC01HOuBA8o0__Qm_Cuvg8XaYawaFtmPhFHdWIMq8kpEXp3VReckYZZ1UFmbr4B5WPwcnp4NG6XP9DACeBXkKMC1o5L25SyyaByj0R8pQImRMh90TILmue3A689hOan4ofEchAdQJibvkjLr_96L-u3wAPIMMv</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Rahimifard, Mahban</creator><creator>Navaei-Nigjeh, Mona</creator><creator>Baeeri, Maryam</creator><creator>Maqbool, Faheem</creator><creator>Abdollahi, Mohammad</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7U7</scope></search><sort><creationdate>20150501</creationdate><title>Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes</title><author>Rahimifard, Mahban ; Navaei-Nigjeh, Mona ; Baeeri, Maryam ; Maqbool, Faheem ; Abdollahi, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-111a8c9b3c858b9132c2e15fa37edd6e3eb81fc99f3d9db642053ff4e6477efb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Antioxidants</topic><topic>Antioxidants (Nutrients)</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cardiology</topic><topic>Caspase 3 - metabolism</topic><topic>Caspase 9 - metabolism</topic><topic>Cell Survival - drug effects</topic><topic>Enzymes</topic><topic>Flow Cytometry</topic><topic>Fluorescence</topic><topic>Humans</topic><topic>Hydrogen peroxide</topic><topic>Hydrogen Peroxide - toxicity</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>Life Sciences</topic><topic>Lipid peroxidation</topic><topic>Lymphocytes</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - metabolism</topic><topic>Lymphocytes - pathology</topic><topic>Medical Biochemistry</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Oncology</topic><topic>Oxidation</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Peroxidation</topic><topic>Protective Agents - pharmacology</topic><topic>Staining and Labeling</topic><topic>Thioctic Acid - pharmacology</topic><topic>Toxicity</topic><topic>Tumor necrosis factor</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahimifard, Mahban</creatorcontrib><creatorcontrib>Navaei-Nigjeh, Mona</creatorcontrib><creatorcontrib>Baeeri, Maryam</creatorcontrib><creatorcontrib>Maqbool, Faheem</creatorcontrib><creatorcontrib>Abdollahi, Mohammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahimifard, Mahban</au><au>Navaei-Nigjeh, Mona</au><au>Baeeri, Maryam</au><au>Maqbool, Faheem</au><au>Abdollahi, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes</atitle><jtitle>Molecular and cellular biochemistry</jtitle><stitle>Mol Cell Biochem</stitle><addtitle>Mol Cell Biochem</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>403</volume><issue>1-2</issue><spage>179</spage><epage>186</epage><pages>179-186</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>The naturally antioxidant and coenzyme, alpha-lipoic acid (α-LA), has gained considerable attention regarding different functions and therapeutically effective in treating oxidative stress-associated diseases in the human body. This study was designed to examine the protective effect of α-LA against H
2
O
2
-induced oxidative stress and apoptosis in human lymphoid cells. Human peripheral blood lymphocytes were preincubated with α-LA and then exposed to H
2
O
2
. After that, the viability of the cells, rate of apoptosis, oxidative stress biomarkers such as reactive oxygen species (ROS) and level of lipid peroxidation (LPO), and also tumor necrosis factor-α (TNF-α) were studied. Pretreatment of lymphocytes with α-LA, dramatically enhanced viability of the cells and decreased apoptosis. Investigation of caspases gives a clear picture of the mechanism by which α-LA decreases ROS and causes a reduction in apoptosis through caspase-9-dependent mitochondrial pathway. Furthermore, α-LA dose dependently decreased oxidative stress by a reduction in level of LPO, and the dose of 1000 µM indicates a significant decrease (
p
< 0.01) in TNF-α level. Collectively, the present data show that α-LA is an ideal compound which has profound protective effects on oxidation, inflammation, and apoptosis. As a result, α-LA may indicate a new way toward the development of antioxidant therapy.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25673508</pmid><doi>10.1007/s11010-015-2348-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 2015-05, Vol.403 (1-2), p.179-186 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1680434994 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Acids Antioxidants Antioxidants (Nutrients) Apoptosis Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Cardiology Caspase 3 - metabolism Caspase 9 - metabolism Cell Survival - drug effects Enzymes Flow Cytometry Fluorescence Humans Hydrogen peroxide Hydrogen Peroxide - toxicity Inflammation Inflammation - pathology Life Sciences Lipid peroxidation Lymphocytes Lymphocytes - drug effects Lymphocytes - metabolism Lymphocytes - pathology Medical Biochemistry Mitochondria - drug effects Mitochondria - metabolism Oncology Oxidation Oxidation-Reduction - drug effects Oxidative stress Oxidative Stress - drug effects Peroxidation Protective Agents - pharmacology Staining and Labeling Thioctic Acid - pharmacology Toxicity Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism |
| title | Multiple protective mechanisms of alpha-lipoic acid in oxidation, apoptosis and inflammation against hydrogen peroxide induced toxicity in human lymphocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T03%3A45%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Multiple%20protective%20mechanisms%20of%20alpha-lipoic%20acid%20in%20oxidation,%20apoptosis%20and%20inflammation%20against%20hydrogen%20peroxide%20induced%20toxicity%20in%20human%20lymphocytes&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Rahimifard,%20Mahban&rft.date=2015-05-01&rft.volume=403&rft.issue=1-2&rft.spage=179&rft.epage=186&rft.pages=179-186&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1007/s11010-015-2348-8&rft_dat=%3Cgale_proqu%3EA430343221%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1669417639&rft_id=info:pmid/25673508&rft_galeid=A430343221&rfr_iscdi=true |