Effects of Lead on Kinetics of super(3)H Dopamine Uptake by Rat Brain Synaptosomes

Effects of Lead on Kinetics of super(3)H Dopamine Uptake by Rat Brain Synaptosomes

Lead inhibits the uptake of tritiated dopamine in synaptosomes of rat brains for both in vivo and in vitro studies. The response is dose related. Dopamine uptake was inhibited at pH 7.5, but in the presence of Pb, uptake of dopamine was inhibited at all pHs tested. In neutral solutions, dopamine upt...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Ecotoxicology and environmental safety 1991-08, Vol.22 (1), p.88-88
Hauptverfasser: Boykin, Michael J, Chetty, Chellu S, Rajanna, Bettaiya
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 88
container_issue 1
container_start_page 88
container_title Ecotoxicology and environmental safety
container_volume 22
creator Boykin, Michael J
Chetty, Chellu S
Rajanna, Bettaiya
description Lead inhibits the uptake of tritiated dopamine in synaptosomes of rat brains for both in vivo and in vitro studies. The response is dose related. Dopamine uptake was inhibited at pH 7.5, but in the presence of Pb, uptake of dopamine was inhibited at all pHs tested. In neutral solutions, dopamine uptake in the presence of Pb was most inhibited. Variations in sodium concentration had variable effects on dopamine uptake by rat brain synaptosomes. ATP activation of dopamine uptake was studied under both the influence and lack of Pb. Lead was found to competitively inhibit uptake of tritiated dopamine in rat brain synaptosomes.
format Article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_16803894</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16803894</sourcerecordid><originalsourceid>FETCH-LOGICAL-p624-b606131e06659d316727b6707947ce8669f2929e2c91e7e1e0add09b4a97b60f3</originalsourceid><addsrcrecordid>eNqFzL1OwzAUBWAPIFEK7-AJwRDp-j8eoRSKiIRUylw5ybUUSGITO0PfnoqyMx3pnE_njCyASVNoxcQFuUzpEwAEKLUg27X32OREg6cVupaGkb52I-au-e3SHHG6FXcb-hiiG44L_YjZfSGtD3TrMn2YXDfS98PoYg4pDJiuyLl3fcLrv1yS3dN6t9oU1dvzy-q-KqLmsqg1aCYYgtbKtoJpw02tDRgrTYOl1tZzyy3yxjI0eISubcHW0tmjAy-W5OZ0G6fwPWPK-6FLDfa9GzHMac90CaK08n8oecmVEuIHA95XEQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14282553</pqid></control><display><type>article</type><title>Effects of Lead on Kinetics of super(3)H Dopamine Uptake by Rat Brain Synaptosomes</title><source>Elsevier ScienceDirect Journals</source><creator>Boykin, Michael J ; Chetty, Chellu S ; Rajanna, Bettaiya</creator><creatorcontrib>Boykin, Michael J ; Chetty, Chellu S ; Rajanna, Bettaiya</creatorcontrib><description>Lead inhibits the uptake of tritiated dopamine in synaptosomes of rat brains for both in vivo and in vitro studies. The response is dose related. Dopamine uptake was inhibited at pH 7.5, but in the presence of Pb, uptake of dopamine was inhibited at all pHs tested. In neutral solutions, dopamine uptake in the presence of Pb was most inhibited. Variations in sodium concentration had variable effects on dopamine uptake by rat brain synaptosomes. ATP activation of dopamine uptake was studied under both the influence and lack of Pb. Lead was found to competitively inhibit uptake of tritiated dopamine in rat brain synaptosomes.</description><identifier>ISSN: 0147-6513</identifier><language>eng</language><ispartof>Ecotoxicology and environmental safety, 1991-08, Vol.22 (1), p.88-88</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>Boykin, Michael J</creatorcontrib><creatorcontrib>Chetty, Chellu S</creatorcontrib><creatorcontrib>Rajanna, Bettaiya</creatorcontrib><title>Effects of Lead on Kinetics of super(3)H Dopamine Uptake by Rat Brain Synaptosomes</title><title>Ecotoxicology and environmental safety</title><description>Lead inhibits the uptake of tritiated dopamine in synaptosomes of rat brains for both in vivo and in vitro studies. The response is dose related. Dopamine uptake was inhibited at pH 7.5, but in the presence of Pb, uptake of dopamine was inhibited at all pHs tested. In neutral solutions, dopamine uptake in the presence of Pb was most inhibited. Variations in sodium concentration had variable effects on dopamine uptake by rat brain synaptosomes. ATP activation of dopamine uptake was studied under both the influence and lack of Pb. Lead was found to competitively inhibit uptake of tritiated dopamine in rat brain synaptosomes.</description><issn>0147-6513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNqFzL1OwzAUBWAPIFEK7-AJwRDp-j8eoRSKiIRUylw5ybUUSGITO0PfnoqyMx3pnE_njCyASVNoxcQFuUzpEwAEKLUg27X32OREg6cVupaGkb52I-au-e3SHHG6FXcb-hiiG44L_YjZfSGtD3TrMn2YXDfS98PoYg4pDJiuyLl3fcLrv1yS3dN6t9oU1dvzy-q-KqLmsqg1aCYYgtbKtoJpw02tDRgrTYOl1tZzyy3yxjI0eISubcHW0tmjAy-W5OZ0G6fwPWPK-6FLDfa9GzHMac90CaK08n8oecmVEuIHA95XEQ</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>Boykin, Michael J</creator><creator>Chetty, Chellu S</creator><creator>Rajanna, Bettaiya</creator><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TK</scope></search><sort><creationdate>19910801</creationdate><title>Effects of Lead on Kinetics of super(3)H Dopamine Uptake by Rat Brain Synaptosomes</title><author>Boykin, Michael J ; Chetty, Chellu S ; Rajanna, Bettaiya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p624-b606131e06659d316727b6707947ce8669f2929e2c91e7e1e0add09b4a97b60f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boykin, Michael J</creatorcontrib><creatorcontrib>Chetty, Chellu S</creatorcontrib><creatorcontrib>Rajanna, Bettaiya</creatorcontrib><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boykin, Michael J</au><au>Chetty, Chellu S</au><au>Rajanna, Bettaiya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Lead on Kinetics of super(3)H Dopamine Uptake by Rat Brain Synaptosomes</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><date>1991-08-01</date><risdate>1991</risdate><volume>22</volume><issue>1</issue><spage>88</spage><epage>88</epage><pages>88-88</pages><issn>0147-6513</issn><abstract>Lead inhibits the uptake of tritiated dopamine in synaptosomes of rat brains for both in vivo and in vitro studies. The response is dose related. Dopamine uptake was inhibited at pH 7.5, but in the presence of Pb, uptake of dopamine was inhibited at all pHs tested. In neutral solutions, dopamine uptake in the presence of Pb was most inhibited. Variations in sodium concentration had variable effects on dopamine uptake by rat brain synaptosomes. ATP activation of dopamine uptake was studied under both the influence and lack of Pb. Lead was found to competitively inhibit uptake of tritiated dopamine in rat brain synaptosomes.</abstract><tpages>1</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0147-6513
ispartof Ecotoxicology and environmental safety, 1991-08, Vol.22 (1), p.88-88
issn 0147-6513
language eng
recordid cdi_proquest_miscellaneous_16803894
source Elsevier ScienceDirect Journals
title Effects of Lead on Kinetics of super(3)H Dopamine Uptake by Rat Brain Synaptosomes
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T02%3A26%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Lead%20on%20Kinetics%20of%20super(3)H%20Dopamine%20Uptake%20by%20Rat%20Brain%20Synaptosomes&rft.jtitle=Ecotoxicology%20and%20environmental%20safety&rft.au=Boykin,%20Michael%20J&rft.date=1991-08-01&rft.volume=22&rft.issue=1&rft.spage=88&rft.epage=88&rft.pages=88-88&rft.issn=0147-6513&rft_id=info:doi/&rft_dat=%3Cproquest%3E16803894%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14282553&rft_id=info:pmid/&rfr_iscdi=true