Silencing of TRPC1 regulates store-operated calcium entry and proliferation in Huh7 hepatocellular carcinoma cells

Abstract Purpose Previously, we observed reciprocal changes in TRPC1 and TRPC6 expression levels in aging rat aorta and A7r5, rat embryonic vascular smooth muscle cells. Furthermore, downregulation of TRPC1 significantly elevated store-operated Ca2+ entry suggesting the regulatory role of TRPC1 in A...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2015-04, Vol.71, p.194-200
Hauptverfasser:	Selli, Cigdem, Erac, Yasemin, Kosova, Buket, Erdal, Esra S, Tosun, Metiner
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium - metabolism Calcium store depletion Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Fura-2 Gene Expression Regulation, Neoplastic - drug effects Gene Silencing - drug effects Humans Indoles - pharmacology Internal Medicine Intracellular Space - metabolism Liver Neoplasms - genetics Liver Neoplasms - pathology Medical Education RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - metabolism Transfection TRP channels TRPC Cation Channels - genetics TRPC Cation Channels - metabolism TRPC6 Cation Channel
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