Dopamine transporter gene may be associated with bipolar disorder and its personality traits
Dopamine transporter and its genetic factors have been suggested to play a critical role in the development of bipolar disorder (BPD). However, the importance of the dopamine transporter gene ( DAT1 ) in the pathogenesis of BPD remains unclear. The aims of this study were to assess 18 polymorphisms...
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| Veröffentlicht in: | European archives of psychiatry and clinical neuroscience 2015-06, Vol.265 (4), p.281-290 |
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| creator | Huang, Chang-Chih Lu, Ru-Band Yen, Che-Hung Yeh, Yi-Wei Chou, Han-Wei Kuo, Shin-Chang Chen, Chun-Yen Chang, Chuan-Chia Chang, Hsin-An Ho, Pei-Shen Liang, Chih-Sung Cheng, Serena Shih, Mei-Chen Huang, San-Yuan |
| description | Dopamine transporter and its genetic factors have been suggested to play a critical role in the development of bipolar disorder (BPD). However, the importance of the dopamine transporter gene (
DAT1
) in the pathogenesis of BPD remains unclear. The aims of this study were to assess 18 polymorphisms of the
DAT1
gene to determine whether this gene is associated with BPD and whether it influences personality traits of patients with BPD.
DAT1
polymorphisms were analyzed in 492 BPD (374 BPDI and 118 BPDII) patients and 436 controls. All participants were screened using the same assessment tool, and all met the criteria for BPD. The Tridimensional Personality Questionnaire was used to assess personality traits in both patients and controls. Several polymorphisms had a weak association with BPD, including rs2550948, rs2652511, and rs2975226 in allele distribution analysis (
P
|
| doi_str_mv | 10.1007/s00406-014-0570-0 |
| format | Article |
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DAT1
) in the pathogenesis of BPD remains unclear. The aims of this study were to assess 18 polymorphisms of the
DAT1
gene to determine whether this gene is associated with BPD and whether it influences personality traits of patients with BPD.
DAT1
polymorphisms were analyzed in 492 BPD (374 BPDI and 118 BPDII) patients and 436 controls. All participants were screened using the same assessment tool, and all met the criteria for BPD. The Tridimensional Personality Questionnaire was used to assess personality traits in both patients and controls. Several polymorphisms had a weak association with BPD, including rs2550948, rs2652511, and rs2975226 in allele distribution analysis (
P
< 0.05). Furthermore, the promoter G-A-C-G haplotype (rs6350-rs2975226-rs2652511-rs6413429) was over-represented in the BPD patients compared to the controls (
P
= 0.007). In personality assessment, the BPDII patients had the highest harm avoidance score, followed by the BPDI patients and controls (
P
= 3.7 × 10
−32
). In addition, a significant association between rs40184 and harm avoidance was found in the patients with BPD. The
DAT1
promoter may be associated with vulnerabilities in BPD. The BPD patients had a higher rate of harm avoidance personality traits than the controls, and
DAT1
variants may influence personality traits in patients with BPD.</description><identifier>ISSN: 0940-1334</identifier><identifier>EISSN: 1433-8491</identifier><identifier>DOI: 10.1007/s00406-014-0570-0</identifier><identifier>PMID: 25547317</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Bipolar Disorder - complications ; Bipolar Disorder - genetics ; Chi-Square Distribution ; Dopamine Plasma Membrane Transport Proteins - genetics ; Female ; Genetic Association Studies ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neurosciences ; Original Paper ; Personality Disorders - complications ; Personality Disorders - genetics ; Personality Inventory ; Polymorphism, Single Nucleotide - genetics ; Psychiatric Status Rating Scales ; Psychiatry ; Taiwan ; Young Adult</subject><ispartof>European archives of psychiatry and clinical neuroscience, 2015-06, Vol.265 (4), p.281-290</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-7749a9febb2fcc68cebca14b3392bfaef418cf9e95e97d34e900201f05ec6aae3</citedby><cites>FETCH-LOGICAL-c442t-7749a9febb2fcc68cebca14b3392bfaef418cf9e95e97d34e900201f05ec6aae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00406-014-0570-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00406-014-0570-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25547317$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Chang-Chih</creatorcontrib><creatorcontrib>Lu, Ru-Band</creatorcontrib><creatorcontrib>Yen, Che-Hung</creatorcontrib><creatorcontrib>Yeh, Yi-Wei</creatorcontrib><creatorcontrib>Chou, Han-Wei</creatorcontrib><creatorcontrib>Kuo, Shin-Chang</creatorcontrib><creatorcontrib>Chen, Chun-Yen</creatorcontrib><creatorcontrib>Chang, Chuan-Chia</creatorcontrib><creatorcontrib>Chang, Hsin-An</creatorcontrib><creatorcontrib>Ho, Pei-Shen</creatorcontrib><creatorcontrib>Liang, Chih-Sung</creatorcontrib><creatorcontrib>Cheng, Serena</creatorcontrib><creatorcontrib>Shih, Mei-Chen</creatorcontrib><creatorcontrib>Huang, San-Yuan</creatorcontrib><title>Dopamine transporter gene may be associated with bipolar disorder and its personality traits</title><title>European archives of psychiatry and clinical neuroscience</title><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><description>Dopamine transporter and its genetic factors have been suggested to play a critical role in the development of bipolar disorder (BPD). However, the importance of the dopamine transporter gene (
DAT1
) in the pathogenesis of BPD remains unclear. The aims of this study were to assess 18 polymorphisms of the
DAT1
gene to determine whether this gene is associated with BPD and whether it influences personality traits of patients with BPD.
DAT1
polymorphisms were analyzed in 492 BPD (374 BPDI and 118 BPDII) patients and 436 controls. All participants were screened using the same assessment tool, and all met the criteria for BPD. The Tridimensional Personality Questionnaire was used to assess personality traits in both patients and controls. Several polymorphisms had a weak association with BPD, including rs2550948, rs2652511, and rs2975226 in allele distribution analysis (
P
< 0.05). Furthermore, the promoter G-A-C-G haplotype (rs6350-rs2975226-rs2652511-rs6413429) was over-represented in the BPD patients compared to the controls (
P
= 0.007). In personality assessment, the BPDII patients had the highest harm avoidance score, followed by the BPDI patients and controls (
P
= 3.7 × 10
−32
). In addition, a significant association between rs40184 and harm avoidance was found in the patients with BPD. The
DAT1
promoter may be associated with vulnerabilities in BPD. The BPD patients had a higher rate of harm avoidance personality traits than the controls, and
DAT1
variants may influence personality traits in patients with BPD.</description><subject>Adult</subject><subject>Bipolar Disorder - complications</subject><subject>Bipolar Disorder - genetics</subject><subject>Chi-Square Distribution</subject><subject>Dopamine Plasma Membrane Transport Proteins - genetics</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genotype</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Personality Disorders - complications</subject><subject>Personality Disorders - genetics</subject><subject>Personality Inventory</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Taiwan</subject><subject>Young Adult</subject><issn>0940-1334</issn><issn>1433-8491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LxDAQhoMouq7-AC8S8OKlOmnSTXMUv2HBi96EkKbTNdI2Neki--_NsquI4Ckwed53hoeQEwYXDEBeRgABswyYyKCQkMEOmTDBeVYKxXbJBJSAjHEuDshhjO8AwIoc9slBXhRCciYn5PXGD6ZzPdIxmD4OPowY6ALToDMrWiE1MXrrzIg1_XTjG63c4FsTaO2iD3WCTV9TN0Y6YIi-N60bV-uyNDoie41pIx5v3yl5ubt9vn7I5k_3j9dX88wKkY-ZlEIZ1WBV5Y21s9JiZQ0TFecqrxqDjWClbRSqApWsuUAFkANroEA7Mwb5lJxveofgP5YYR925aLFtTY9-GTWblSlQqrxM6Nkf9N0vQ7p6TUklZSlVkSi2oWzwMQZs9BBcZ8JKM9Br9XqjXif1eq1eQ8qcbpuXVYf1T-LbdQLyDRDTV7_A8Gv1v61fenqP5A</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Huang, Chang-Chih</creator><creator>Lu, Ru-Band</creator><creator>Yen, Che-Hung</creator><creator>Yeh, Yi-Wei</creator><creator>Chou, Han-Wei</creator><creator>Kuo, Shin-Chang</creator><creator>Chen, Chun-Yen</creator><creator>Chang, Chuan-Chia</creator><creator>Chang, Hsin-An</creator><creator>Ho, Pei-Shen</creator><creator>Liang, Chih-Sung</creator><creator>Cheng, Serena</creator><creator>Shih, Mei-Chen</creator><creator>Huang, San-Yuan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Dopamine transporter gene may be associated with bipolar disorder and its personality traits</title><author>Huang, Chang-Chih ; Lu, Ru-Band ; Yen, Che-Hung ; Yeh, Yi-Wei ; Chou, Han-Wei ; Kuo, Shin-Chang ; Chen, Chun-Yen ; Chang, Chuan-Chia ; Chang, Hsin-An ; Ho, Pei-Shen ; Liang, Chih-Sung ; Cheng, Serena ; Shih, Mei-Chen ; Huang, San-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-7749a9febb2fcc68cebca14b3392bfaef418cf9e95e97d34e900201f05ec6aae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Bipolar Disorder - complications</topic><topic>Bipolar Disorder - genetics</topic><topic>Chi-Square Distribution</topic><topic>Dopamine Plasma Membrane Transport Proteins - genetics</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genotype</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Personality Disorders - complications</topic><topic>Personality Disorders - genetics</topic><topic>Personality Inventory</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Taiwan</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Chang-Chih</creatorcontrib><creatorcontrib>Lu, Ru-Band</creatorcontrib><creatorcontrib>Yen, Che-Hung</creatorcontrib><creatorcontrib>Yeh, Yi-Wei</creatorcontrib><creatorcontrib>Chou, Han-Wei</creatorcontrib><creatorcontrib>Kuo, Shin-Chang</creatorcontrib><creatorcontrib>Chen, Chun-Yen</creatorcontrib><creatorcontrib>Chang, Chuan-Chia</creatorcontrib><creatorcontrib>Chang, Hsin-An</creatorcontrib><creatorcontrib>Ho, Pei-Shen</creatorcontrib><creatorcontrib>Liang, Chih-Sung</creatorcontrib><creatorcontrib>Cheng, Serena</creatorcontrib><creatorcontrib>Shih, Mei-Chen</creatorcontrib><creatorcontrib>Huang, San-Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of psychiatry and clinical neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Chang-Chih</au><au>Lu, Ru-Band</au><au>Yen, Che-Hung</au><au>Yeh, Yi-Wei</au><au>Chou, Han-Wei</au><au>Kuo, Shin-Chang</au><au>Chen, Chun-Yen</au><au>Chang, Chuan-Chia</au><au>Chang, Hsin-An</au><au>Ho, Pei-Shen</au><au>Liang, Chih-Sung</au><au>Cheng, Serena</au><au>Shih, Mei-Chen</au><au>Huang, San-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopamine transporter gene may be associated with bipolar disorder and its personality traits</atitle><jtitle>European archives of psychiatry and clinical neuroscience</jtitle><stitle>Eur Arch Psychiatry Clin Neurosci</stitle><addtitle>Eur Arch Psychiatry Clin Neurosci</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>265</volume><issue>4</issue><spage>281</spage><epage>290</epage><pages>281-290</pages><issn>0940-1334</issn><eissn>1433-8491</eissn><abstract>Dopamine transporter and its genetic factors have been suggested to play a critical role in the development of bipolar disorder (BPD). However, the importance of the dopamine transporter gene (
DAT1
) in the pathogenesis of BPD remains unclear. The aims of this study were to assess 18 polymorphisms of the
DAT1
gene to determine whether this gene is associated with BPD and whether it influences personality traits of patients with BPD.
DAT1
polymorphisms were analyzed in 492 BPD (374 BPDI and 118 BPDII) patients and 436 controls. All participants were screened using the same assessment tool, and all met the criteria for BPD. The Tridimensional Personality Questionnaire was used to assess personality traits in both patients and controls. Several polymorphisms had a weak association with BPD, including rs2550948, rs2652511, and rs2975226 in allele distribution analysis (
P
< 0.05). Furthermore, the promoter G-A-C-G haplotype (rs6350-rs2975226-rs2652511-rs6413429) was over-represented in the BPD patients compared to the controls (
P
= 0.007). In personality assessment, the BPDII patients had the highest harm avoidance score, followed by the BPDI patients and controls (
P
= 3.7 × 10
−32
). In addition, a significant association between rs40184 and harm avoidance was found in the patients with BPD. The
DAT1
promoter may be associated with vulnerabilities in BPD. The BPD patients had a higher rate of harm avoidance personality traits than the controls, and
DAT1
variants may influence personality traits in patients with BPD.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25547317</pmid><doi>10.1007/s00406-014-0570-0</doi><tpages>10</tpages></addata></record> |
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| ispartof | European archives of psychiatry and clinical neuroscience, 2015-06, Vol.265 (4), p.281-290 |
| issn | 0940-1334 1433-8491 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Bipolar Disorder - complications Bipolar Disorder - genetics Chi-Square Distribution Dopamine Plasma Membrane Transport Proteins - genetics Female Genetic Association Studies Genotype Humans Linkage Disequilibrium Male Medicine Medicine & Public Health Middle Aged Neurosciences Original Paper Personality Disorders - complications Personality Disorders - genetics Personality Inventory Polymorphism, Single Nucleotide - genetics Psychiatric Status Rating Scales Psychiatry Taiwan Young Adult |
| title | Dopamine transporter gene may be associated with bipolar disorder and its personality traits |
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