The cysteine-rich core domain of REIC/Dkk-3 is critical for its effect on monocyte differentiation and tumor regression

Reduced expression in immortalized cells (REIC)/Dickkopf (Dkk)-3 is a tumor-suppressor gene and has been studied as a promising therapeutic gene for cancer gene therapy. Intratumoral injection of an adenovirus vector carrying the human REIC/Dkk-3 gene (Ad-REIC) elicits cancer cell-specific apoptosis...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncology reports 2015-06, Vol.33 (6), p.2908-2914
Hauptverfasser:	KINOSHITA, RIE, WATANABE, MASAMI, HUANG, PENG, LI, SHUN-AI, SAKAGUCHI, MASAKIYO, KUMON, HIROMI, FUTAMI, JUNICHIRO
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Animals anticancer immune Apoptosis - drug effects Cancer research Cancer therapies Cancer treatment Cell differentiation Cell Differentiation - genetics Cell Line, Tumor Chromatography Cloning Cysteine - genetics Cytokines dendritic cell Dendritic Cells - metabolism Dendritic Cells - pathology Gene expression Gene Expression Regulation, Neoplastic Gene therapy Genetic aspects Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 beta Health aspects Humans Injections, Intraperitoneal Intercellular Signaling Peptides and Proteins - administration & dosage Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - genetics Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Mice monocyte Monocytes - metabolism Monocytes - pathology Phosphorylation Plasmids Protein Structure, Tertiary - genetics protein therapy Proteins REIC STAT Transcription Factors - genetics T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - pathology Tumor suppressor genes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!