Lymphoproliferative disease and cancer among patients with common variable immunodeficiency

Highlights • Common variable immunodeficiency (CVI) is the commonest primary antibody disorder. • A higher frequency of malignancy, especially lymphoma, has been reported. • The reasons for the increased susceptibility to lymphoid malignancies are unclear. • This review discusses the latest insights...

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Veröffentlicht in:	Leukemia research 2015-04, Vol.39 (4), p.389-396
Hauptverfasser:	Gangemi, S, Allegra, A, Musolino, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Common variable immunodeficiency Common Variable Immunodeficiency - complications Disease Susceptibility Gastric cancer Hematology, Oncology and Palliative Medicine Humans Immune dysregulation Innate immune deficiency Lymphoma Lymphoproliferative Disorders - etiology Neoplasms - etiology Risk Factors
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Zusammenfassung:	Highlights • Common variable immunodeficiency (CVI) is the commonest primary antibody disorder. • A higher frequency of malignancy, especially lymphoma, has been reported. • The reasons for the increased susceptibility to lymphoid malignancies are unclear. • This review discusses the latest insights into the links CVI and malignancies.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.02.002