Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies
Abstract A large number of imaging studies have examined the neural correlates of consummatory pleasure and anticipatory pleasure in schizophrenia, but the brain regions where schizophrenia patients consistently demonstrate dysfunctions remain unclear. We performed a series of meta-analyses on imagi...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2015-03, Vol.231 (3), p.187-196 |
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| creator | Yan, Chao Yang, Tammy Yu, Qi-jing Jin, Zhen Cheung, Eric F.C Liu, Xun Chan, Raymond C.K |
| description | Abstract A large number of imaging studies have examined the neural correlates of consummatory pleasure and anticipatory pleasure in schizophrenia, but the brain regions where schizophrenia patients consistently demonstrate dysfunctions remain unclear. We performed a series of meta-analyses on imaging studies to delineate the regions associated with consummatory and anticipatory pleasure dysfunctions in schizophrenia. Nineteen functional magnetic resonance imaging or positron emission tomography studies using whole brain analysis were identified through a literature search (PubMed and EBSCO; January 1990–February 2014). Activation likelihood estimation was performed using the GingerALE software. The clusters identified were obtained after controlling for the false discovery rate at p |
| doi_str_mv | 10.1016/j.pscychresns.2015.01.001 |
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We performed a series of meta-analyses on imaging studies to delineate the regions associated with consummatory and anticipatory pleasure dysfunctions in schizophrenia. Nineteen functional magnetic resonance imaging or positron emission tomography studies using whole brain analysis were identified through a literature search (PubMed and EBSCO; January 1990–February 2014). Activation likelihood estimation was performed using the GingerALE software. The clusters identified were obtained after controlling for the false discovery rate at p <0.05 and applying a minimum cluster size of 200 mm3 . It was found that schizophrenia patients exhibited decreased activation mainly in the rostral medial prefrontal cortex (rmPFC), the right parahippocampus/amygala, and other limbic regions (e.g., the subgenual anterior cingulate cortex, the putamen, and the medial globus pallidus) when consummating pleasure. Task instructions (feeling vs. stimuli) were differentially related to medial prefrontal dysfunction in schizophrenia. When patients anticipated pleasure, reduced activation in the left putamen was observed, despite the limited number of studies. Our findings suggest that the medial prefrontal cortex and limbic regions may play an important role in neural dysfunction underlying deficits in consummatory pleasure in schizophrenia.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2015.01.001</identifier><identifier>PMID: 25637357</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Activation likelihood estimation ; Adult ; Anticipatory pleasure ; Consummatory Behavior - physiology ; Consummatory pleasure ; Female ; Gyrus Cinguli - physiopathology ; Humans ; Magnetic Resonance Imaging - methods ; Male ; Medial prefrontal cortex ; Pleasure - physiology ; Positron-Emission Tomography - methods ; Prefrontal Cortex - physiopathology ; Psychiatry ; Putamen - physiopathology ; Radiology ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - physiopathology</subject><ispartof>Psychiatry research. Neuroimaging, 2015-03, Vol.231 (3), p.187-196</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-d95dd327a3a1803d599211777b6dcd8588de8fce5a881dbfc2867227fd2b973</citedby><cites>FETCH-LOGICAL-c601t-d95dd327a3a1803d599211777b6dcd8588de8fce5a881dbfc2867227fd2b973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pscychresns.2015.01.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25637357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yan, Chao</creatorcontrib><creatorcontrib>Yang, Tammy</creatorcontrib><creatorcontrib>Yu, Qi-jing</creatorcontrib><creatorcontrib>Jin, Zhen</creatorcontrib><creatorcontrib>Cheung, Eric F.C</creatorcontrib><creatorcontrib>Liu, Xun</creatorcontrib><creatorcontrib>Chan, Raymond C.K</creatorcontrib><title>Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res</addtitle><description>Abstract A large number of imaging studies have examined the neural correlates of consummatory pleasure and anticipatory pleasure in schizophrenia, but the brain regions where schizophrenia patients consistently demonstrate dysfunctions remain unclear. We performed a series of meta-analyses on imaging studies to delineate the regions associated with consummatory and anticipatory pleasure dysfunctions in schizophrenia. Nineteen functional magnetic resonance imaging or positron emission tomography studies using whole brain analysis were identified through a literature search (PubMed and EBSCO; January 1990–February 2014). Activation likelihood estimation was performed using the GingerALE software. The clusters identified were obtained after controlling for the false discovery rate at p <0.05 and applying a minimum cluster size of 200 mm3 . It was found that schizophrenia patients exhibited decreased activation mainly in the rostral medial prefrontal cortex (rmPFC), the right parahippocampus/amygala, and other limbic regions (e.g., the subgenual anterior cingulate cortex, the putamen, and the medial globus pallidus) when consummating pleasure. Task instructions (feeling vs. stimuli) were differentially related to medial prefrontal dysfunction in schizophrenia. When patients anticipated pleasure, reduced activation in the left putamen was observed, despite the limited number of studies. Our findings suggest that the medial prefrontal cortex and limbic regions may play an important role in neural dysfunction underlying deficits in consummatory pleasure in schizophrenia.</description><subject>Activation likelihood estimation</subject><subject>Adult</subject><subject>Anticipatory pleasure</subject><subject>Consummatory Behavior - physiology</subject><subject>Consummatory pleasure</subject><subject>Female</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medial prefrontal cortex</subject><subject>Pleasure - physiology</subject><subject>Positron-Emission Tomography - methods</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychiatry</subject><subject>Putamen - physiopathology</subject><subject>Radiology</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - physiopathology</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhi0EokvhLyBz45Lgj_VHOCBVK6CVKiFR7pbXdloviR08CVI48dPxaluEONWXmcM773jmGYTeUNJSQuW7QzuBW91dCZCgZYSKltCWEPoEbahWrFGCyKdoQzommm3H1Bl6AXAghHEt-XN0xoTkigu1Qb-_ZpiLHfAYfKxhKqEvOc019Sv0S3JzzAmwTR67mizjaOdcVjwNwcJSAo4Jg7uLv_JU_5OifY8vqtlsG5vssEIEnHv8YFRt42hvY7rFMC8-BniJnvV2gPDqPp6jm08fv-0um-svn692F9eNk4TOje-E95wpyy3VhHvRdYxSpdReeue10NoH3bsgrNbU73vHtFSMqd6zfaf4OXp7cp1K_rEEmM0YwYVhsCnkBQyVmtBuS_j2EVKpmdRK6SrtTlJXMkDdnJlKHa-shhJzJGUO5h9S5kjKEGoqqVr7-r7Nsq-7_1v5gKYKdidBqFv5GUMx4GJIrnIqwc3G5_ioNh_-c3FDTNHZ4XtYAxzyUiqUOpUBZoi5OZ7M8WKoIPUxwf8AyJTDKQ</recordid><startdate>20150330</startdate><enddate>20150330</enddate><creator>Yan, Chao</creator><creator>Yang, Tammy</creator><creator>Yu, Qi-jing</creator><creator>Jin, Zhen</creator><creator>Cheung, Eric F.C</creator><creator>Liu, Xun</creator><creator>Chan, Raymond C.K</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20150330</creationdate><title>Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies</title><author>Yan, Chao ; Yang, Tammy ; Yu, Qi-jing ; Jin, Zhen ; Cheung, Eric F.C ; Liu, Xun ; Chan, Raymond C.K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-d95dd327a3a1803d599211777b6dcd8588de8fce5a881dbfc2867227fd2b973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Activation likelihood estimation</topic><topic>Adult</topic><topic>Anticipatory pleasure</topic><topic>Consummatory Behavior - physiology</topic><topic>Consummatory pleasure</topic><topic>Female</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medial prefrontal cortex</topic><topic>Pleasure - physiology</topic><topic>Positron-Emission Tomography - methods</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychiatry</topic><topic>Putamen - physiopathology</topic><topic>Radiology</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Chao</creatorcontrib><creatorcontrib>Yang, Tammy</creatorcontrib><creatorcontrib>Yu, Qi-jing</creatorcontrib><creatorcontrib>Jin, Zhen</creatorcontrib><creatorcontrib>Cheung, Eric F.C</creatorcontrib><creatorcontrib>Liu, Xun</creatorcontrib><creatorcontrib>Chan, Raymond C.K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research. Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Chao</au><au>Yang, Tammy</au><au>Yu, Qi-jing</au><au>Jin, Zhen</au><au>Cheung, Eric F.C</au><au>Liu, Xun</au><au>Chan, Raymond C.K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res</addtitle><date>2015-03-30</date><risdate>2015</risdate><volume>231</volume><issue>3</issue><spage>187</spage><epage>196</epage><pages>187-196</pages><issn>0925-4927</issn><eissn>1872-7506</eissn><abstract>Abstract A large number of imaging studies have examined the neural correlates of consummatory pleasure and anticipatory pleasure in schizophrenia, but the brain regions where schizophrenia patients consistently demonstrate dysfunctions remain unclear. We performed a series of meta-analyses on imaging studies to delineate the regions associated with consummatory and anticipatory pleasure dysfunctions in schizophrenia. Nineteen functional magnetic resonance imaging or positron emission tomography studies using whole brain analysis were identified through a literature search (PubMed and EBSCO; January 1990–February 2014). Activation likelihood estimation was performed using the GingerALE software. The clusters identified were obtained after controlling for the false discovery rate at p <0.05 and applying a minimum cluster size of 200 mm3 . It was found that schizophrenia patients exhibited decreased activation mainly in the rostral medial prefrontal cortex (rmPFC), the right parahippocampus/amygala, and other limbic regions (e.g., the subgenual anterior cingulate cortex, the putamen, and the medial globus pallidus) when consummating pleasure. Task instructions (feeling vs. stimuli) were differentially related to medial prefrontal dysfunction in schizophrenia. When patients anticipated pleasure, reduced activation in the left putamen was observed, despite the limited number of studies. Our findings suggest that the medial prefrontal cortex and limbic regions may play an important role in neural dysfunction underlying deficits in consummatory pleasure in schizophrenia.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25637357</pmid><doi>10.1016/j.pscychresns.2015.01.001</doi><tpages>10</tpages></addata></record> |
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| subjects | Activation likelihood estimation Adult Anticipatory pleasure Consummatory Behavior - physiology Consummatory pleasure Female Gyrus Cinguli - physiopathology Humans Magnetic Resonance Imaging - methods Male Medial prefrontal cortex Pleasure - physiology Positron-Emission Tomography - methods Prefrontal Cortex - physiopathology Psychiatry Putamen - physiopathology Radiology Schizophrenia Schizophrenia - diagnosis Schizophrenia - physiopathology |
| title | Rostral medial prefrontal dysfunctions and consummatory pleasure in schizophrenia: A meta-analysis of functional imaging studies |
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