Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers
Objective Prediabetes is a condition between a normal metabolic state and diabetes mellitus, which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), or both. Prediabetes is related with undesirable cardiovascular outcomes. Epicardial fat thickness (EFT) has been correlated w...
Gespeichert in:
| Veröffentlicht in: | Internal Medicine 2015, Vol.54(9), pp.1009-1014 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1014 |
|---|---|
| container_issue | 9 |
| container_start_page | 1009 |
| container_title | Internal Medicine |
| container_volume | 54 |
| creator | Arpaci, Dilek Ugurlu, Burcak Polat Aslan, Abdullah Nabi Ersoy, Reyhan Akcay, Murat Cakir, Bekir |
| description | Objective Prediabetes is a condition between a normal metabolic state and diabetes mellitus, which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), or both. Prediabetes is related with undesirable cardiovascular outcomes. Epicardial fat thickness (EFT) has been correlated with cardiovascular risk factors. We herein aimed to assess EFT in prediabetic patients. Methods We evaluated 64 patients with prediabetes and 30 age- and gender-matched healthy subjects. Demographic and anthropometric characteristics [age, sex, height, weight, body mass index (BMI), and waist circumference (WC)] and laboratory findings [fasting plasma glucose (FPG), postprandial plasma glucose (PPG), hemoglobin A1c (HbA1c), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglycerides (TG)] were assessed. Transthoracic echocardiography was used to evaluate EFT. Results There were no significant differences between the case and control groups in terms of age, gender, height, HDL, WC, systolic and diastolic blood pressure (SBP/DBP), or TG (p>0.05). Body weight, BMI, FPG, LDL, and, in particular, EFT were found to be significantly higher in the case group than control group (p |
| doi_str_mv | 10.2169/internalmedicine.54.3714 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1680193942</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1680193942</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-b888597f297ae55e0986f873e093103ed1e648ef530cc2b370ba3955d0bb3eb43</originalsourceid><addsrcrecordid>eNptkE9PGzEQxa2qVQm0XwH52MsG_1nv2scqAopEAVX0bM16Z4mJ401tB9Rvz0ZJc6i4zIw0v_ee9AihnM0Fb8yFjwVThLDG3jsfca7quWx5_YHMuKxN1QqpPpIZM1xXYhon5DTnZ8akbo34TE6EMrWW0sxIuNx4B6n3EOgVFPq49G4VMWfqI32A4jGWTF99WdKHNKVBhwUzhdjTxZgShgkZ4x64L0tMdLFzG18gu22ARH_5vKI_Ia0w5S_k0wAh49fDPiO_ry4fFz-q2_vrm8X328op0ZSq01or0w7CtIBKITO6GXQrp0NyJrHn2NQaByWZc6KTLetAGqV61nUSu1qekW97300a_2wxF7v22WEIEHHcZssbzbiRphYTqveoS2POCQe7SX4N6a_lzO66tv93bVVtd11P0vNDyrabnkfhv3In4G4PPOcCT3gEIBXvAr7rbHbjkHAE3RKSxSjfAL5Jnko</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1680193942</pqid></control><display><type>article</type><title>Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>Arpaci, Dilek ; Ugurlu, Burcak Polat ; Aslan, Abdullah Nabi ; Ersoy, Reyhan ; Akcay, Murat ; Cakir, Bekir</creator><creatorcontrib>Arpaci, Dilek ; Ugurlu, Burcak Polat ; Aslan, Abdullah Nabi ; Ersoy, Reyhan ; Akcay, Murat ; Cakir, Bekir</creatorcontrib><description>Objective Prediabetes is a condition between a normal metabolic state and diabetes mellitus, which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), or both. Prediabetes is related with undesirable cardiovascular outcomes. Epicardial fat thickness (EFT) has been correlated with cardiovascular risk factors. We herein aimed to assess EFT in prediabetic patients. Methods We evaluated 64 patients with prediabetes and 30 age- and gender-matched healthy subjects. Demographic and anthropometric characteristics [age, sex, height, weight, body mass index (BMI), and waist circumference (WC)] and laboratory findings [fasting plasma glucose (FPG), postprandial plasma glucose (PPG), hemoglobin A1c (HbA1c), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglycerides (TG)] were assessed. Transthoracic echocardiography was used to evaluate EFT. Results There were no significant differences between the case and control groups in terms of age, gender, height, HDL, WC, systolic and diastolic blood pressure (SBP/DBP), or TG (p>0.05). Body weight, BMI, FPG, LDL, and, in particular, EFT were found to be significantly higher in the case group than control group (p<0.05). When compared with the control group, the median EFT was significantly higher in all prediabetic subgroups (IGT or IFG, p<0.001). However, no statistically significant difference was found between each case subgroup (p=0.795). When groups were adjusted according to age, sex, WC, and BMI with covariance test, the EFT remained increased in the prediabetes subgroups compared to the controls (p<0.001). Conclusion We found the EFT levels to be increased in all subgroups of prediabetic patients regardless of FPG and HbA1c. Furthermore, EFT directly correlated with the patients' BMI and WC.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.54.3714</identifier><identifier>PMID: 25948339</identifier><language>eng</language><publisher>Japan: The Japanese Society of Internal Medicine</publisher><subject>Adult ; Aged ; Blood Glucose - metabolism ; Blood Pressure ; Body Mass Index ; cardiovascular ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - pathology ; Echocardiography ; epicardial fat ; Female ; glucose ; Glucose Intolerance - blood ; Glycated Hemoglobin A - analysis ; Humans ; Male ; Middle Aged ; Pericardium - metabolism ; Pericardium - pathology ; prediabetic ; Prediabetic State - pathology ; Risk Factors ; Triglycerides - blood ; Waist Circumference</subject><ispartof>Internal Medicine, 2015, Vol.54(9), pp.1009-1014</ispartof><rights>2015 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-b888597f297ae55e0986f873e093103ed1e648ef530cc2b370ba3955d0bb3eb43</citedby><cites>FETCH-LOGICAL-c526t-b888597f297ae55e0986f873e093103ed1e648ef530cc2b370ba3955d0bb3eb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25948339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arpaci, Dilek</creatorcontrib><creatorcontrib>Ugurlu, Burcak Polat</creatorcontrib><creatorcontrib>Aslan, Abdullah Nabi</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Akcay, Murat</creatorcontrib><creatorcontrib>Cakir, Bekir</creatorcontrib><title>Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>Objective Prediabetes is a condition between a normal metabolic state and diabetes mellitus, which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), or both. Prediabetes is related with undesirable cardiovascular outcomes. Epicardial fat thickness (EFT) has been correlated with cardiovascular risk factors. We herein aimed to assess EFT in prediabetic patients. Methods We evaluated 64 patients with prediabetes and 30 age- and gender-matched healthy subjects. Demographic and anthropometric characteristics [age, sex, height, weight, body mass index (BMI), and waist circumference (WC)] and laboratory findings [fasting plasma glucose (FPG), postprandial plasma glucose (PPG), hemoglobin A1c (HbA1c), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglycerides (TG)] were assessed. Transthoracic echocardiography was used to evaluate EFT. Results There were no significant differences between the case and control groups in terms of age, gender, height, HDL, WC, systolic and diastolic blood pressure (SBP/DBP), or TG (p>0.05). Body weight, BMI, FPG, LDL, and, in particular, EFT were found to be significantly higher in the case group than control group (p<0.05). When compared with the control group, the median EFT was significantly higher in all prediabetic subgroups (IGT or IFG, p<0.001). However, no statistically significant difference was found between each case subgroup (p=0.795). When groups were adjusted according to age, sex, WC, and BMI with covariance test, the EFT remained increased in the prediabetes subgroups compared to the controls (p<0.001). Conclusion We found the EFT levels to be increased in all subgroups of prediabetic patients regardless of FPG and HbA1c. Furthermore, EFT directly correlated with the patients' BMI and WC.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>cardiovascular</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Echocardiography</subject><subject>epicardial fat</subject><subject>Female</subject><subject>glucose</subject><subject>Glucose Intolerance - blood</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pericardium - metabolism</subject><subject>Pericardium - pathology</subject><subject>prediabetic</subject><subject>Prediabetic State - pathology</subject><subject>Risk Factors</subject><subject>Triglycerides - blood</subject><subject>Waist Circumference</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE9PGzEQxa2qVQm0XwH52MsG_1nv2scqAopEAVX0bM16Z4mJ401tB9Rvz0ZJc6i4zIw0v_ee9AihnM0Fb8yFjwVThLDG3jsfca7quWx5_YHMuKxN1QqpPpIZM1xXYhon5DTnZ8akbo34TE6EMrWW0sxIuNx4B6n3EOgVFPq49G4VMWfqI32A4jGWTF99WdKHNKVBhwUzhdjTxZgShgkZ4x64L0tMdLFzG18gu22ARH_5vKI_Ia0w5S_k0wAh49fDPiO_ry4fFz-q2_vrm8X328op0ZSq01or0w7CtIBKITO6GXQrp0NyJrHn2NQaByWZc6KTLetAGqV61nUSu1qekW97300a_2wxF7v22WEIEHHcZssbzbiRphYTqveoS2POCQe7SX4N6a_lzO66tv93bVVtd11P0vNDyrabnkfhv3In4G4PPOcCT3gEIBXvAr7rbHbjkHAE3RKSxSjfAL5Jnko</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Arpaci, Dilek</creator><creator>Ugurlu, Burcak Polat</creator><creator>Aslan, Abdullah Nabi</creator><creator>Ersoy, Reyhan</creator><creator>Akcay, Murat</creator><creator>Cakir, Bekir</creator><general>The Japanese Society of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers</title><author>Arpaci, Dilek ; Ugurlu, Burcak Polat ; Aslan, Abdullah Nabi ; Ersoy, Reyhan ; Akcay, Murat ; Cakir, Bekir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-b888597f297ae55e0986f873e093103ed1e648ef530cc2b370ba3955d0bb3eb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>cardiovascular</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Echocardiography</topic><topic>epicardial fat</topic><topic>Female</topic><topic>glucose</topic><topic>Glucose Intolerance - blood</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pericardium - metabolism</topic><topic>Pericardium - pathology</topic><topic>prediabetic</topic><topic>Prediabetic State - pathology</topic><topic>Risk Factors</topic><topic>Triglycerides - blood</topic><topic>Waist Circumference</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arpaci, Dilek</creatorcontrib><creatorcontrib>Ugurlu, Burcak Polat</creatorcontrib><creatorcontrib>Aslan, Abdullah Nabi</creatorcontrib><creatorcontrib>Ersoy, Reyhan</creatorcontrib><creatorcontrib>Akcay, Murat</creatorcontrib><creatorcontrib>Cakir, Bekir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arpaci, Dilek</au><au>Ugurlu, Burcak Polat</au><au>Aslan, Abdullah Nabi</au><au>Ersoy, Reyhan</au><au>Akcay, Murat</au><au>Cakir, Bekir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>54</volume><issue>9</issue><spage>1009</spage><epage>1014</epage><pages>1009-1014</pages><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>Objective Prediabetes is a condition between a normal metabolic state and diabetes mellitus, which includes impaired glucose tolerance (IGT), impaired fasting glucose (IFG), or both. Prediabetes is related with undesirable cardiovascular outcomes. Epicardial fat thickness (EFT) has been correlated with cardiovascular risk factors. We herein aimed to assess EFT in prediabetic patients. Methods We evaluated 64 patients with prediabetes and 30 age- and gender-matched healthy subjects. Demographic and anthropometric characteristics [age, sex, height, weight, body mass index (BMI), and waist circumference (WC)] and laboratory findings [fasting plasma glucose (FPG), postprandial plasma glucose (PPG), hemoglobin A1c (HbA1c), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglycerides (TG)] were assessed. Transthoracic echocardiography was used to evaluate EFT. Results There were no significant differences between the case and control groups in terms of age, gender, height, HDL, WC, systolic and diastolic blood pressure (SBP/DBP), or TG (p>0.05). Body weight, BMI, FPG, LDL, and, in particular, EFT were found to be significantly higher in the case group than control group (p<0.05). When compared with the control group, the median EFT was significantly higher in all prediabetic subgroups (IGT or IFG, p<0.001). However, no statistically significant difference was found between each case subgroup (p=0.795). When groups were adjusted according to age, sex, WC, and BMI with covariance test, the EFT remained increased in the prediabetes subgroups compared to the controls (p<0.001). Conclusion We found the EFT levels to be increased in all subgroups of prediabetic patients regardless of FPG and HbA1c. Furthermore, EFT directly correlated with the patients' BMI and WC.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>25948339</pmid><doi>10.2169/internalmedicine.54.3714</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0918-2918 |
| ispartof | Internal Medicine, 2015, Vol.54(9), pp.1009-1014 |
| issn | 0918-2918 1349-7235 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1680193942 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Adult Aged Blood Glucose - metabolism Blood Pressure Body Mass Index cardiovascular Cardiovascular Diseases - etiology Cardiovascular Diseases - pathology Echocardiography epicardial fat Female glucose Glucose Intolerance - blood Glycated Hemoglobin A - analysis Humans Male Middle Aged Pericardium - metabolism Pericardium - pathology prediabetic Prediabetic State - pathology Risk Factors Triglycerides - blood Waist Circumference |
| title | Epicardial Fat Thickness in Patients with Prediabetes and Correlation with Other Cardiovascular Risk Markers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T03%3A38%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Epicardial%20Fat%20Thickness%20in%20Patients%20with%20Prediabetes%20and%20Correlation%20with%20Other%20Cardiovascular%20Risk%20Markers&rft.jtitle=Internal%20Medicine&rft.au=Arpaci,%20Dilek&rft.date=2015-01-01&rft.volume=54&rft.issue=9&rft.spage=1009&rft.epage=1014&rft.pages=1009-1014&rft.issn=0918-2918&rft.eissn=1349-7235&rft_id=info:doi/10.2169/internalmedicine.54.3714&rft_dat=%3Cproquest_cross%3E1680193942%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1680193942&rft_id=info:pmid/25948339&rfr_iscdi=true |