Synthesis, biological and electrochemical evaluation of novel nitroaromatics as potential anticancerous drugs

Nitroaromatics i.e. 1-nitro-4-phenoxybenzene (1), 4-(4-nitrophenyloxy) biphenyl (2), 1-(4-nitrophenoxy) naphthalene (3) and 2-(4-nitrophenoxy) naphthalene (4) were synthesized by Williamson etherification and characterized by elemental analysis, FTIR, NMR (1H, 13C), UV–visible spectroscopy, mass spe...

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Veröffentlicht in:	Bioelectrochemistry (Amsterdam, Netherlands) Netherlands), 2015-08, Vol.104, p.85-92
Hauptverfasser:	Shabbir, Muhammad, Akhter, Zareen, Ahmad, Iqbal, Ahmed, Safeer, Ismail, Hammad, Mirza, Bushra, Mckee, Vickie, Bolte, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Artemia Chemistry Techniques, Synthetic DNA - metabolism Drug Screening Assays, Antitumor Drug–DNA intercalation Electrochemistry Free Radical Scavengers - chemical synthesis Free Radical Scavengers - chemistry Free Radical Scavengers - metabolism Free Radical Scavengers - pharmacology Humans Hydroxyl Radical - chemistry Nitro Compounds - chemical synthesis Nitro Compounds - chemistry Nitro Compounds - metabolism Nitro Compounds - pharmacology Nitroaromatics Reversible electron transfer
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Zusammenfassung:	Nitroaromatics i.e. 1-nitro-4-phenoxybenzene (1), 4-(4-nitrophenyloxy) biphenyl (2), 1-(4-nitrophenoxy) naphthalene (3) and 2-(4-nitrophenoxy) naphthalene (4) were synthesized by Williamson etherification and characterized by elemental analysis, FTIR, NMR (1H, 13C), UV–visible spectroscopy, mass spectrometry and single crystal X-ray diffraction analysis. Their brine shrimp cytotoxicity resulted in LD50 values
ISSN:	1567-5394 1878-562X
DOI:	10.1016/j.bioelechem.2015.03.007