Polyclonality among clinical strains of non-pigmented rapidly growing mycobacteria: phenotypic and genotypic differences and their potential implications
To investigate the potential implications (especially the implications in clinical significance and antimicrobial susceptibility) of polyclonality among rapidly growing mycobacteria, we performed random amplified polymorphic DNA analysis in 64 clinical isolates of which the clinical significance was...
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| Veröffentlicht in: | Clinical microbiology and infection 2015-04, Vol.21 (4), p.348.e1-348.e4 |
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| container_end_page | 348.e4 |
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| container_title | Clinical microbiology and infection |
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| creator | García-Pedrazuela, M. Frutos, J.M. Muñoz-Egea, M.C. Alcaide, F. Tórtola, T. Vitoria, A. Cortés, P. Esteban, J. |
| description | To investigate the potential implications (especially the implications in clinical significance and antimicrobial susceptibility) of polyclonality among rapidly growing mycobacteria, we performed random amplified polymorphic DNA analysis in 64 clinical isolates of which the clinical significance was established. Phenotypic characteristics (antimicrobial susceptibility test, colony morphology and growth rate) of each clone were studied. Polyclonality was detected in 13 of the isolates (20.3%). There was a relationship between monoclonality and clinical significance (p 0.0096). Monoclonal and polyclonal isolates showed different behaviour in antimicrobial susceptibility. There was a strong relationship between monoclonality and those species that are more pathogenic for humans, and also with clinical significance of the isolates. |
| doi_str_mv | 10.1016/j.cmi.2014.12.004 |
| format | Article |
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Phenotypic characteristics (antimicrobial susceptibility test, colony morphology and growth rate) of each clone were studied. Polyclonality was detected in 13 of the isolates (20.3%). There was a relationship between monoclonality and clinical significance (p 0.0096). Monoclonal and polyclonal isolates showed different behaviour in antimicrobial susceptibility. 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Phenotypic characteristics (antimicrobial susceptibility test, colony morphology and growth rate) of each clone were studied. Polyclonality was detected in 13 of the isolates (20.3%). There was a relationship between monoclonality and clinical significance (p 0.0096). Monoclonal and polyclonal isolates showed different behaviour in antimicrobial susceptibility. There was a strong relationship between monoclonality and those species that are more pathogenic for humans, and also with clinical significance of the isolates.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25596780</pmid><doi>10.1016/j.cmi.2014.12.004</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - pharmacology Genetic Variation Genotype Genotypic Humans Microbial Sensitivity Tests Molecular Typing Mycobacterium Infections, Nontuberculous - epidemiology Mycobacterium Infections, Nontuberculous - microbiology Nontuberculous Mycobacteria - classification Nontuberculous Mycobacteria - drug effects Nontuberculous Mycobacteria - growth & development Nontuberculous Mycobacteria - isolation & purification Phenotype Pigments, Biological - analysis polyclonality random amplified polymorphic DNA Random Amplified Polymorphic DNA Technique rapidly growing mycobacteria susceptibility |
| title | Polyclonality among clinical strains of non-pigmented rapidly growing mycobacteria: phenotypic and genotypic differences and their potential implications |
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