Predictive Value of Programmed Ventricular Stimulation After Catheter Ablation of Post-Infarction Ventricular Tachycardia
Abstract Background A recent meta-analysis demonstrated a survival benefit in post-infarction patients whose ventricular tachycardia (VT) was rendered noninducible by catheter ablation. Furthermore, patients with noninducible VT had a lower VT recurrence rate than did patients whose VT remained indu...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2015-05, Vol.65 (18), p.1954-1959 |
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| creator | Yokokawa, Miki, MD Kim, Hyungjin Myra, ScD Baser, Kazim, MD Stevenson, William, MD Nagashima, Koichi, MD Della Bella, Paolo, MD Vergara, Pasquale, MD Hindricks, Gerhard, MD Arya, Arash, MD Zeppenfeld, Katja, MD de Riva Silva, Marta, MD Daoud, Emile G., MD Kumar, Sunil, MD Kuck, Karl-Heinz, MD Tilz, Ronald, MD Mathew, Shibu, MD Ghanbari, Hamid, MD Latchamsetty, Rakesh, MD Morady, Fred, MD Bogun, Frank M., MD |
| description | Abstract Background A recent meta-analysis demonstrated a survival benefit in post-infarction patients whose ventricular tachycardia (VT) was rendered noninducible by catheter ablation. Furthermore, patients with noninducible VT had a lower VT recurrence rate than did patients whose VT remained inducible after ablation. Objectives The purpose of this multicenter cohort study was to assess whether noninducibility after VT ablation is independently associated with improved survival. Methods Data from 1,064 patients who underwent VT ablation for post-infarction VT at seven international centers were analyzed. The ablation procedure was considered successful if no VT was inducible at the end of the procedure and unsuccessful if VT remained inducible or if programmed stimulation was not performed at the end of the ablation. Results Median follow-up time was 633 days. Noninducibility was independently associated with lower mortality (adjusted hazard ratio: 0.65; 95% confidence interval: 0.53 to 0.79; p < 0.001). Atrial fibrillation, diabetes, and age were other independent predictors of higher mortality. Ablation of only the clinical VT in patients who also had inducible, nonclinical VTs was not associated with improved survival. Conclusions Noninducibility after VT ablation in patients with post-infarction VT is independently associated with lower mortality during long-term follow-up. |
| doi_str_mv | 10.1016/j.jacc.2015.02.058 |
| format | Article |
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Furthermore, patients with noninducible VT had a lower VT recurrence rate than did patients whose VT remained inducible after ablation. Objectives The purpose of this multicenter cohort study was to assess whether noninducibility after VT ablation is independently associated with improved survival. Methods Data from 1,064 patients who underwent VT ablation for post-infarction VT at seven international centers were analyzed. The ablation procedure was considered successful if no VT was inducible at the end of the procedure and unsuccessful if VT remained inducible or if programmed stimulation was not performed at the end of the ablation. Results Median follow-up time was 633 days. Noninducibility was independently associated with lower mortality (adjusted hazard ratio: 0.65; 95% confidence interval: 0.53 to 0.79; p < 0.001). Atrial fibrillation, diabetes, and age were other independent predictors of higher mortality. Ablation of only the clinical VT in patients who also had inducible, nonclinical VTs was not associated with improved survival. Conclusions Noninducibility after VT ablation in patients with post-infarction VT is independently associated with lower mortality during long-term follow-up.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2015.02.058</identifier><identifier>PMID: 25913000</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ablation ; Age Factors ; Aged ; Atrial Fibrillation - epidemiology ; Cardiac arrhythmia ; Cardiology ; Cardiovascular ; Catheter Ablation ; Catheters ; Cohort Studies ; Diabetes Mellitus - epidemiology ; Electric Stimulation ; Female ; Follow-Up Studies ; Heart attacks ; Humans ; Internal Medicine ; Male ; Mortality ; Myocardial Infarction - complications ; Myocardial Infarction - mortality ; Recurrence ; Tachycardia, Ventricular - etiology ; Tachycardia, Ventricular - mortality ; Tachycardia, Ventricular - surgery</subject><ispartof>Journal of the American College of Cardiology, 2015-05, Vol.65 (18), p.1954-1959</ispartof><rights>American College of Cardiology Foundation</rights><rights>2015 American College of Cardiology Foundation</rights><rights>Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited May 12, 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-8835fb1536c53c8e6d5818fef6bfe7a603afeb5e4da59e96f824023aa434cd443</citedby><cites>FETCH-LOGICAL-c439t-8835fb1536c53c8e6d5818fef6bfe7a603afeb5e4da59e96f824023aa434cd443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2015.02.058$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25913000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yokokawa, Miki, MD</creatorcontrib><creatorcontrib>Kim, Hyungjin Myra, ScD</creatorcontrib><creatorcontrib>Baser, Kazim, MD</creatorcontrib><creatorcontrib>Stevenson, William, MD</creatorcontrib><creatorcontrib>Nagashima, Koichi, MD</creatorcontrib><creatorcontrib>Della Bella, Paolo, MD</creatorcontrib><creatorcontrib>Vergara, Pasquale, MD</creatorcontrib><creatorcontrib>Hindricks, Gerhard, MD</creatorcontrib><creatorcontrib>Arya, Arash, MD</creatorcontrib><creatorcontrib>Zeppenfeld, Katja, MD</creatorcontrib><creatorcontrib>de Riva Silva, Marta, MD</creatorcontrib><creatorcontrib>Daoud, Emile G., MD</creatorcontrib><creatorcontrib>Kumar, Sunil, MD</creatorcontrib><creatorcontrib>Kuck, Karl-Heinz, MD</creatorcontrib><creatorcontrib>Tilz, Ronald, MD</creatorcontrib><creatorcontrib>Mathew, Shibu, MD</creatorcontrib><creatorcontrib>Ghanbari, Hamid, MD</creatorcontrib><creatorcontrib>Latchamsetty, Rakesh, MD</creatorcontrib><creatorcontrib>Morady, Fred, MD</creatorcontrib><creatorcontrib>Bogun, Frank M., MD</creatorcontrib><title>Predictive Value of Programmed Ventricular Stimulation After Catheter Ablation of Post-Infarction Ventricular Tachycardia</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Abstract Background A recent meta-analysis demonstrated a survival benefit in post-infarction patients whose ventricular tachycardia (VT) was rendered noninducible by catheter ablation. Furthermore, patients with noninducible VT had a lower VT recurrence rate than did patients whose VT remained inducible after ablation. Objectives The purpose of this multicenter cohort study was to assess whether noninducibility after VT ablation is independently associated with improved survival. Methods Data from 1,064 patients who underwent VT ablation for post-infarction VT at seven international centers were analyzed. The ablation procedure was considered successful if no VT was inducible at the end of the procedure and unsuccessful if VT remained inducible or if programmed stimulation was not performed at the end of the ablation. Results Median follow-up time was 633 days. Noninducibility was independently associated with lower mortality (adjusted hazard ratio: 0.65; 95% confidence interval: 0.53 to 0.79; p < 0.001). Atrial fibrillation, diabetes, and age were other independent predictors of higher mortality. Ablation of only the clinical VT in patients who also had inducible, nonclinical VTs was not associated with improved survival. Conclusions Noninducibility after VT ablation in patients with post-infarction VT is independently associated with lower mortality during long-term follow-up.</description><subject>ablation</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Atrial Fibrillation - epidemiology</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cardiovascular</subject><subject>Catheter Ablation</subject><subject>Catheters</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Electric Stimulation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Mortality</subject><subject>Myocardial Infarction - complications</subject><subject>Myocardial Infarction - mortality</subject><subject>Recurrence</subject><subject>Tachycardia, Ventricular - etiology</subject><subject>Tachycardia, Ventricular - mortality</subject><subject>Tachycardia, Ventricular - surgery</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1q3DAUhUVpaCZpX6CLYugmGzuSZdkSlMIw9CcQSCBptkKWrxq5tpVKcmD6NH2WPFnlzqQtWXSlK-k7B-mei9BrgguCSX3aF73SuigxYQUuC8z4M7QijPGcMtE8RyvcUJYTLJpDdBRCjzGuOREv0GHJBKFpu0I_Lj10Vkd7D9mNGmbInMkuvfvq1ThCl93AFL3V86B8dhXtmIpo3ZStTQSfbVS8hVQ8_Fy3-4tF7kLMzyajvP599K_HtdK3W618Z9VLdGDUEODVfj1GXz5-uN58zs8vPp1t1ue5rqiIOeeUmZYwWmtGNYe6Y5xwA6ZuDTSqxlQZaBlUnWICRG14WeGSKlXRSndVRY_Ryc73zrvvM4QoRxs0DIOawM1BkppjwlNDSELfPkF7N_spvW6hCCOCiiZR5Y7S3oXgwcg7b0flt5JguSQje7kkI5dkJC5lSiaJ3uyt5zY19o_kMYoEvNsBkHpxb8HLoC1MOsXjQUfZOft___dP5Hqwk9Vq-AZbCH__IUMSyKtlNpbRIAxjkQr6CzPGtjA</recordid><startdate>20150512</startdate><enddate>20150512</enddate><creator>Yokokawa, Miki, MD</creator><creator>Kim, Hyungjin Myra, ScD</creator><creator>Baser, Kazim, MD</creator><creator>Stevenson, William, MD</creator><creator>Nagashima, Koichi, MD</creator><creator>Della Bella, Paolo, MD</creator><creator>Vergara, Pasquale, MD</creator><creator>Hindricks, Gerhard, MD</creator><creator>Arya, Arash, MD</creator><creator>Zeppenfeld, Katja, MD</creator><creator>de Riva Silva, Marta, MD</creator><creator>Daoud, Emile G., MD</creator><creator>Kumar, Sunil, MD</creator><creator>Kuck, Karl-Heinz, MD</creator><creator>Tilz, Ronald, MD</creator><creator>Mathew, Shibu, MD</creator><creator>Ghanbari, Hamid, MD</creator><creator>Latchamsetty, Rakesh, MD</creator><creator>Morady, Fred, MD</creator><creator>Bogun, Frank M., MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20150512</creationdate><title>Predictive Value of Programmed Ventricular Stimulation After Catheter Ablation of Post-Infarction Ventricular Tachycardia</title><author>Yokokawa, Miki, MD ; Kim, Hyungjin Myra, ScD ; Baser, Kazim, MD ; Stevenson, William, MD ; Nagashima, Koichi, MD ; Della Bella, Paolo, MD ; Vergara, Pasquale, MD ; Hindricks, Gerhard, MD ; Arya, Arash, MD ; Zeppenfeld, Katja, MD ; de Riva Silva, Marta, MD ; Daoud, Emile G., MD ; Kumar, Sunil, MD ; Kuck, Karl-Heinz, MD ; Tilz, Ronald, MD ; Mathew, Shibu, MD ; Ghanbari, Hamid, MD ; Latchamsetty, Rakesh, MD ; Morady, Fred, MD ; Bogun, Frank M., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-8835fb1536c53c8e6d5818fef6bfe7a603afeb5e4da59e96f824023aa434cd443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>ablation</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Atrial Fibrillation - epidemiology</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Cardiovascular</topic><topic>Catheter Ablation</topic><topic>Catheters</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus - epidemiology</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Mortality</topic><topic>Myocardial Infarction - complications</topic><topic>Myocardial Infarction - mortality</topic><topic>Recurrence</topic><topic>Tachycardia, Ventricular - etiology</topic><topic>Tachycardia, Ventricular - mortality</topic><topic>Tachycardia, Ventricular - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yokokawa, Miki, MD</creatorcontrib><creatorcontrib>Kim, Hyungjin Myra, ScD</creatorcontrib><creatorcontrib>Baser, Kazim, MD</creatorcontrib><creatorcontrib>Stevenson, William, MD</creatorcontrib><creatorcontrib>Nagashima, Koichi, MD</creatorcontrib><creatorcontrib>Della Bella, Paolo, MD</creatorcontrib><creatorcontrib>Vergara, Pasquale, MD</creatorcontrib><creatorcontrib>Hindricks, Gerhard, MD</creatorcontrib><creatorcontrib>Arya, Arash, MD</creatorcontrib><creatorcontrib>Zeppenfeld, Katja, MD</creatorcontrib><creatorcontrib>de Riva Silva, Marta, MD</creatorcontrib><creatorcontrib>Daoud, Emile G., MD</creatorcontrib><creatorcontrib>Kumar, Sunil, MD</creatorcontrib><creatorcontrib>Kuck, Karl-Heinz, MD</creatorcontrib><creatorcontrib>Tilz, Ronald, MD</creatorcontrib><creatorcontrib>Mathew, Shibu, MD</creatorcontrib><creatorcontrib>Ghanbari, Hamid, MD</creatorcontrib><creatorcontrib>Latchamsetty, Rakesh, MD</creatorcontrib><creatorcontrib>Morady, Fred, MD</creatorcontrib><creatorcontrib>Bogun, Frank M., MD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yokokawa, Miki, MD</au><au>Kim, Hyungjin Myra, ScD</au><au>Baser, Kazim, MD</au><au>Stevenson, William, MD</au><au>Nagashima, Koichi, MD</au><au>Della Bella, Paolo, MD</au><au>Vergara, Pasquale, MD</au><au>Hindricks, Gerhard, MD</au><au>Arya, Arash, MD</au><au>Zeppenfeld, Katja, MD</au><au>de Riva Silva, Marta, MD</au><au>Daoud, Emile G., MD</au><au>Kumar, Sunil, MD</au><au>Kuck, Karl-Heinz, MD</au><au>Tilz, Ronald, MD</au><au>Mathew, Shibu, MD</au><au>Ghanbari, Hamid, MD</au><au>Latchamsetty, Rakesh, MD</au><au>Morady, Fred, MD</au><au>Bogun, Frank M., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictive Value of Programmed Ventricular Stimulation After Catheter Ablation of Post-Infarction Ventricular Tachycardia</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2015-05-12</date><risdate>2015</risdate><volume>65</volume><issue>18</issue><spage>1954</spage><epage>1959</epage><pages>1954-1959</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>Abstract Background A recent meta-analysis demonstrated a survival benefit in post-infarction patients whose ventricular tachycardia (VT) was rendered noninducible by catheter ablation. Furthermore, patients with noninducible VT had a lower VT recurrence rate than did patients whose VT remained inducible after ablation. Objectives The purpose of this multicenter cohort study was to assess whether noninducibility after VT ablation is independently associated with improved survival. Methods Data from 1,064 patients who underwent VT ablation for post-infarction VT at seven international centers were analyzed. The ablation procedure was considered successful if no VT was inducible at the end of the procedure and unsuccessful if VT remained inducible or if programmed stimulation was not performed at the end of the ablation. Results Median follow-up time was 633 days. Noninducibility was independently associated with lower mortality (adjusted hazard ratio: 0.65; 95% confidence interval: 0.53 to 0.79; p < 0.001). Atrial fibrillation, diabetes, and age were other independent predictors of higher mortality. Ablation of only the clinical VT in patients who also had inducible, nonclinical VTs was not associated with improved survival. Conclusions Noninducibility after VT ablation in patients with post-infarction VT is independently associated with lower mortality during long-term follow-up.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25913000</pmid><doi>10.1016/j.jacc.2015.02.058</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | ablation Age Factors Aged Atrial Fibrillation - epidemiology Cardiac arrhythmia Cardiology Cardiovascular Catheter Ablation Catheters Cohort Studies Diabetes Mellitus - epidemiology Electric Stimulation Female Follow-Up Studies Heart attacks Humans Internal Medicine Male Mortality Myocardial Infarction - complications Myocardial Infarction - mortality Recurrence Tachycardia, Ventricular - etiology Tachycardia, Ventricular - mortality Tachycardia, Ventricular - surgery |
| title | Predictive Value of Programmed Ventricular Stimulation After Catheter Ablation of Post-Infarction Ventricular Tachycardia |
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