Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting

Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the therapeutic index compared with untargeted...

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Veröffentlicht in:	International journal of pharmaceutics 2015-05, Vol.486 (1-2), p.287-296
Hauptverfasser:	Swami, Rajan, Singh, Indu, Jeengar, Manish Kumar, Naidu, V G M, Khan, Wahid, Sistla, Ramakrishna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - administration & dosage Adenosine - chemistry Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Apoptosis - drug effects Cell Line, Tumor Cell Survival - drug effects Humans Lipids - administration & dosage Lipids - chemistry Mice Nanoparticles - administration & dosage Nanoparticles - chemistry Neoplasms - drug therapy Taxoids - administration & dosage Taxoids - chemistry Taxoids - pharmacokinetics
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