Genetic alterations of DNA methylation machinery in human diseases

DNA methylation plays a critical role in the regulation of chromatin structure and gene expression and is involved in a variety of biological processes. The levels and patterns of DNA methylation are regulated by both DNA methyltransferases (DNMT1, DNMT3A and DNMT3B) and 'demethylating' pr...

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Veröffentlicht in:	Epigenomics 2015-04, Vol.7 (2), p.247-265
Hauptverfasser:	Hamidi, Tewfik, Singh, Anup Kumar, Chen, Taiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids AML Analysis Biological activity Biotechnology Care and treatment Chromatin Deoxyribonucleic acid Developmental disabilities Diagnosis Disease - genetics DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA Methylation DNA-Binding Proteins - genetics DNMT DNMT1 protein Embryonic development Gene expression Genomes Humans ICF syndrome Leukemia Localization Mammals MBD MeCP2 MeCP2 protein Methyl-CpG binding protein Methyl-CpG-Binding Protein 2 - genetics Methylation Mixed Function Oxygenases Mutation Neoplasms - genetics Neurons Phenotypes Phosphorylation Proteins Proto-Oncogene Proteins - genetics Rett syndrome Rett Syndrome - genetics TET
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