Establishment of a novel and highly permissive cell line for the efficient replication of cyprinid herpesvirus 2 (CyHV-2)

•A novel cell line from the brain of gibel carp (GiCB) has been established and characterized.•The GiCB cell line can consistently propagate CyHV-2 to high concentrations.•The ultrastructural morphogenesis of CyHV-2 in an established cell line was first observed by TEM.•The CyHV-2 virion produced in...

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Veröffentlicht in:	Veterinary microbiology 2015-06, Vol.177 (3-4), p.315-325
Hauptverfasser:	Ma, Jie, Jiang, Nan, LaPatra, Scott E., Jin, Ling, Xu, Jin, Fan, Yuding, Zhou, Yong, Zeng, Lingbing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aquaculture Brain Brain - cytology Brain - virology Cell line Cell Line - cytology Cell Line - virology Cyprinid herpesvirus 2 (CyHV-2) DNA Helicases - genetics DNA, Viral - isolation & purification Fish Diseases - virology Gene Expression Regulation, Viral Gibel carp (Carassius auratus gibelio) Goldfish - virology Herpesviridae - enzymology Herpesviridae - genetics Herpesviridae - pathogenicity Herpesviridae - physiology Herpesviridae Infections - veterinary Herpesviridae Infections - virology In Situ Hybridization, Fluorescence Kidney - virology Rabbits Replication Spleen - virology Viral Proteins - genetics Viral Proteins - metabolism Virus Replication
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