Pharmacokinetic interaction of intravenous fentanyl with ketoconazole

Fentanyl is primarily metabolized by CYP3A, but has also been suggested to act as a weak inhibitor of CYP3A. We investigated the influence of CYP3A inhibition by ketoconazole on the pharmacokinetics of intravenously administered fentanyl and the effect of fentanyl on CYP3A activity. A prospective, o...

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Veröffentlicht in:	Journal of clinical pharmacology 2015-06, Vol.55 (6), p.708-717
Hauptverfasser:	Ziesenitz, Victoria C., König, Sonja K., Mahlke, Nina S., Skopp, Gisela, Haefeli, Walter E., Mikus, Gerd
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacokinetics Chromatography, Liquid Cross-Over Studies CYP3A inhibition Cytochrome P-450 CYP3A - blood Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 CYP3A - urine Cytochrome P-450 CYP3A Inhibitors - administration & dosage Cytochrome P-450 CYP3A Inhibitors - pharmacokinetics Drug Interactions Female fentanyl Fentanyl - administration & dosage Fentanyl - analogs & derivatives Fentanyl - blood Fentanyl - metabolism Fentanyl - pharmacokinetics Fentanyl - urine Healthy Volunteers Humans ketoconazole Ketoconazole - administration & dosage Ketoconazole - pharmacokinetics Male Midazolam - administration & dosage Middle Aged Naloxone - administration & dosage Prospective Studies Tandem Mass Spectrometry Young Adult
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