The Activation Mechanism of 2'-5'-Oligoadenylate Synthetase Gives New Insights Into OAS/cGAS Triggers of Innate Immunity

2'-5'-Oligoadenylate synthetases (OASs) produce the second messenger 2'-5'-oligoadenylate, which activates RNase L to induce an intrinsic antiviral state. We report on the crystal structures of catalytic intermediates of OAS1 including the OAS1·dsRNA complex without substrates, w...

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Veröffentlicht in:	Structure (London) 2015-05, Vol.23 (5), p.851-862
Hauptverfasser:	Lohöfener, Jan, Steinke, Nicola, Kay-Fedorov, Penelope, Baruch, Petra, Nikulin, Alexey, Tishchenko, Svetlana, Manstein, Dietmar J, Fedorov, Roman
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - chemistry 2',5'-Oligoadenylate Synthetase - genetics 2',5'-Oligoadenylate Synthetase - metabolism Animals Catalytic Domain Crystallography, X-Ray Enzyme Activation Immunity, Innate Magnesium - metabolism Models, Molecular Nucleotidyltransferases - chemistry Nucleotidyltransferases - metabolism Point Mutation Protein Structure, Secondary RNA, Double-Stranded - chemistry RNA, Double-Stranded - metabolism Swine - genetics Swine - immunology Swine - metabolism
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