Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

By using gene expression data, gastric cancer is divided into subtypes associated with distinct molecular alterations and clinical prognosis. Gastric cancer, a leading cause of cancer-related deaths, is a heterogeneous disease. We aim to establish clinically relevant molecular subtypes that would en...

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Veröffentlicht in:	Nature medicine 2015-05, Vol.21 (5), p.449-456
Hauptverfasser:	Cristescu, Razvan, Lee, Jeeyun, Nebozhyn, Michael, Kim, Kyoung-Mee, Ting, Jason C, Wong, Swee Seong, Liu, Jiangang, Yue, Yong Gang, Wang, Jian, Yu, Kun, Ye, Xiang S, Do, In-Gu, Liu, Shawn, Gong, Lara, Fu, Jake, Jin, Jason Gang, Choi, Min Gew, Sohn, Tae Sung, Lee, Joon Ho, Bae, Jae Moon, Kim, Seung Tae, Park, Se Hoon, Sohn, Insuk, Jung, Sin-Ho, Tan, Patrick, Chen, Ronghua, Hardwick, James, Kang, Won Ki, Ayers, Mark, Hongyue, Dai, Reinhard, Christoph, Loboda, Andrey, Kim, Sung, Aggarwal, Amit
Format:	Artikel
Sprache:	eng
Schlagworte:	38 38/39 45/61 631/67/69 692/308/575 692/53/2422 692/699/1503/1828/1829 Aged Biomedicine Cancer Research Clinical outcomes Cohort Studies Development and progression Disease Progression Epithelial-Mesenchymal Transition Female Gastric cancer Gene Dosage Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Helicobacter pylori - genetics Heterogeneity Humans Identification and classification Infectious Diseases Male Metabolic Diseases Microsatellite Repeats - genetics Middle Aged Molecular Medicine Mutation Neurosciences Oligonucleotide Array Sequence Analysis Principal Component Analysis Prognosis Proportional Hazards Models Proteins Recurrence Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - therapy Studies Tissue Array Analysis Translational Medical Research Treatment Outcome Tumor proteins Tumor Suppressor Protein p53 - genetics Tumors
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