Microvascular blood flow resistance: Role of red blood cell migration and dispersion
Microvascular blood flow resistance has a strong impact on cardiovascular function and tissue perfusion. The flow resistance in microcirculation is governed by flow behavior of blood through a complex network of vessels, where the distribution of red blood cells across vessel cross-sections may be s...
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| Veröffentlicht in: | Microvascular research 2015-05, Vol.99, p.57-66 |
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| creator | Katanov, Dinar Gompper, Gerhard Fedosov, Dmitry A. |
| description | Microvascular blood flow resistance has a strong impact on cardiovascular function and tissue perfusion. The flow resistance in microcirculation is governed by flow behavior of blood through a complex network of vessels, where the distribution of red blood cells across vessel cross-sections may be significantly distorted at vessel bifurcations and junctions. In this paper, the development of blood flow and its resistance starting from a dispersed configuration of red blood cells is investigated in simulations for different hematocrit levels, flow rates, vessel diameters, and aggregation interactions between red blood cells. Initially dispersed red blood cells migrate toward the vessel center leading to the formation of a cell-free layer near the wall and to a decrease of the flow resistance. The development of cell-free layer appears to be nearly universal when scaled with a characteristic shear rate of the flow. The universality allows an estimation of the length of a vessel required for full flow development, lc≲25D, for vessel diameters in the range 10 μm |
| doi_str_mv | 10.1016/j.mvr.2015.02.006 |
| format | Article |
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•Microvascular blood flow resistance is affected by the distribution of red blood cells.•Red blood cell migration under various flow conditions has been quantified.•The length of a vessel required for the full development of cell-free layer is shorter than 25vesseldiameters.•A theoretical model for the converged cell-free layer thickness has been developed.</description><identifier>ISSN: 0026-2862</identifier><identifier>EISSN: 1095-9319</identifier><identifier>DOI: 10.1016/j.mvr.2015.02.006</identifier><identifier>PMID: 25724979</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Algorithms ; Blood Flow Velocity - physiology ; Blood Viscosity - physiology ; Cell Movement ; Cell-free layer ; Cell-Free System ; Computer Simulation ; Erythrocytes - cytology ; Erythrocytes - physiology ; Hematocrit ; Hemodynamics ; Humans ; Lift force ; Mesoscopic simulation ; Microcirculation ; Microcirculation - physiology ; Microvessels - physiology ; Models, Biological ; Models, Cardiovascular ; Motion ; Shear-induced pressure ; Smoothed dissipative particle dynamics ; Viscosity</subject><ispartof>Microvascular research, 2015-05, Vol.99, p.57-66</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-34cff491435948b55536ccb340e6eb6920f48266a6018855d83b877a013542723</citedby><cites>FETCH-LOGICAL-c419t-34cff491435948b55536ccb340e6eb6920f48266a6018855d83b877a013542723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mvr.2015.02.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25724979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katanov, Dinar</creatorcontrib><creatorcontrib>Gompper, Gerhard</creatorcontrib><creatorcontrib>Fedosov, Dmitry A.</creatorcontrib><title>Microvascular blood flow resistance: Role of red blood cell migration and dispersion</title><title>Microvascular research</title><addtitle>Microvasc Res</addtitle><description>Microvascular blood flow resistance has a strong impact on cardiovascular function and tissue perfusion. The flow resistance in microcirculation is governed by flow behavior of blood through a complex network of vessels, where the distribution of red blood cells across vessel cross-sections may be significantly distorted at vessel bifurcations and junctions. In this paper, the development of blood flow and its resistance starting from a dispersed configuration of red blood cells is investigated in simulations for different hematocrit levels, flow rates, vessel diameters, and aggregation interactions between red blood cells. Initially dispersed red blood cells migrate toward the vessel center leading to the formation of a cell-free layer near the wall and to a decrease of the flow resistance. The development of cell-free layer appears to be nearly universal when scaled with a characteristic shear rate of the flow. The universality allows an estimation of the length of a vessel required for full flow development, lc≲25D, for vessel diameters in the range 10 μm<D<100μm. Thus, the potential effect of red blood cell dispersion at vessel bifurcations and junctions on the flow resistance may be significant in vessels which are shorter or comparable to the length lc. Aggregation interactions between red blood cells generally lead to a reduction of blood flow resistance. The simulations are performed using the same viscosity for both external and internal fluids and the RBC membrane viscosity is not considered; however, we discuss how the viscosity contrast may affect the results. Finally, we develop a simple theoretical model which is able to describe the converged cell-free-layer thickness at steady-state flow with respect to flow rate. The model is based on the balance between a lift force on red blood cells due to cell-wall hydrodynamic interactions and shear-induced effective pressure due to cell–cell interactions in flow. We expect that these results can also be used to better understand the flow behavior of other suspensions of deformable particles such as vesicles, capsules, and cells.
•Microvascular blood flow resistance is affected by the distribution of red blood cells.•Red blood cell migration under various flow conditions has been quantified.•The length of a vessel required for the full development of cell-free layer is shorter than 25vesseldiameters.•A theoretical model for the converged cell-free layer thickness has been developed.</description><subject>Algorithms</subject><subject>Blood Flow Velocity - physiology</subject><subject>Blood Viscosity - physiology</subject><subject>Cell Movement</subject><subject>Cell-free layer</subject><subject>Cell-Free System</subject><subject>Computer Simulation</subject><subject>Erythrocytes - cytology</subject><subject>Erythrocytes - physiology</subject><subject>Hematocrit</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>Lift force</subject><subject>Mesoscopic simulation</subject><subject>Microcirculation</subject><subject>Microcirculation - physiology</subject><subject>Microvessels - physiology</subject><subject>Models, Biological</subject><subject>Models, Cardiovascular</subject><subject>Motion</subject><subject>Shear-induced pressure</subject><subject>Smoothed dissipative particle dynamics</subject><subject>Viscosity</subject><issn>0026-2862</issn><issn>1095-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMouq7-AC_So5fWSZqkjZ5k8QtWBFnPIU1TydI2a9Ku-O9N2dWjp2GGZ15mHoQuMGQYML9eZ93WZwQwy4BkAPwAzTAIlooci0M0AyA8JSUnJ-g0hDUAxkyQY3RCWEGoKMQMrV6s9m6rgh5b5ZOqda5OmtZ9Jd4EGwbVa3OTvLnWJK6Js3qPaNO2SWc_vBqs6xPV10ltw8b4ENszdNSoNpjzfZ2j94f71eIpXb4-Pi_ulqmmWAxpTnXTUIFpzgQtK8ZYzrWucgqGm4oLAg0tCeeKAy5Lxuoyr8qiUIBzRklB8jm62uVuvPscTRhkZ8N0meqNG4PEvARcCCATindo_DYEbxq58bZT_ltikJNMuZZRppxkSiAyyow7l_v4sepM_bfxay8CtzvAxCe31ngZtDXRWG290YOsnf0n_gcIU4OX</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Katanov, Dinar</creator><creator>Gompper, Gerhard</creator><creator>Fedosov, Dmitry A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Microvascular blood flow resistance: Role of red blood cell migration and dispersion</title><author>Katanov, Dinar ; Gompper, Gerhard ; Fedosov, Dmitry A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-34cff491435948b55536ccb340e6eb6920f48266a6018855d83b877a013542723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Algorithms</topic><topic>Blood Flow Velocity - physiology</topic><topic>Blood Viscosity - physiology</topic><topic>Cell Movement</topic><topic>Cell-free layer</topic><topic>Cell-Free System</topic><topic>Computer Simulation</topic><topic>Erythrocytes - cytology</topic><topic>Erythrocytes - physiology</topic><topic>Hematocrit</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>Lift force</topic><topic>Mesoscopic simulation</topic><topic>Microcirculation</topic><topic>Microcirculation - physiology</topic><topic>Microvessels - physiology</topic><topic>Models, Biological</topic><topic>Models, Cardiovascular</topic><topic>Motion</topic><topic>Shear-induced pressure</topic><topic>Smoothed dissipative particle dynamics</topic><topic>Viscosity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katanov, Dinar</creatorcontrib><creatorcontrib>Gompper, Gerhard</creatorcontrib><creatorcontrib>Fedosov, Dmitry A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microvascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katanov, Dinar</au><au>Gompper, Gerhard</au><au>Fedosov, Dmitry A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microvascular blood flow resistance: Role of red blood cell migration and dispersion</atitle><jtitle>Microvascular research</jtitle><addtitle>Microvasc Res</addtitle><date>2015-05</date><risdate>2015</risdate><volume>99</volume><spage>57</spage><epage>66</epage><pages>57-66</pages><issn>0026-2862</issn><eissn>1095-9319</eissn><abstract>Microvascular blood flow resistance has a strong impact on cardiovascular function and tissue perfusion. The flow resistance in microcirculation is governed by flow behavior of blood through a complex network of vessels, where the distribution of red blood cells across vessel cross-sections may be significantly distorted at vessel bifurcations and junctions. In this paper, the development of blood flow and its resistance starting from a dispersed configuration of red blood cells is investigated in simulations for different hematocrit levels, flow rates, vessel diameters, and aggregation interactions between red blood cells. Initially dispersed red blood cells migrate toward the vessel center leading to the formation of a cell-free layer near the wall and to a decrease of the flow resistance. The development of cell-free layer appears to be nearly universal when scaled with a characteristic shear rate of the flow. The universality allows an estimation of the length of a vessel required for full flow development, lc≲25D, for vessel diameters in the range 10 μm<D<100μm. Thus, the potential effect of red blood cell dispersion at vessel bifurcations and junctions on the flow resistance may be significant in vessels which are shorter or comparable to the length lc. Aggregation interactions between red blood cells generally lead to a reduction of blood flow resistance. The simulations are performed using the same viscosity for both external and internal fluids and the RBC membrane viscosity is not considered; however, we discuss how the viscosity contrast may affect the results. Finally, we develop a simple theoretical model which is able to describe the converged cell-free-layer thickness at steady-state flow with respect to flow rate. The model is based on the balance between a lift force on red blood cells due to cell-wall hydrodynamic interactions and shear-induced effective pressure due to cell–cell interactions in flow. We expect that these results can also be used to better understand the flow behavior of other suspensions of deformable particles such as vesicles, capsules, and cells.
•Microvascular blood flow resistance is affected by the distribution of red blood cells.•Red blood cell migration under various flow conditions has been quantified.•The length of a vessel required for the full development of cell-free layer is shorter than 25vesseldiameters.•A theoretical model for the converged cell-free layer thickness has been developed.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25724979</pmid><doi>10.1016/j.mvr.2015.02.006</doi><tpages>10</tpages></addata></record> |
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| subjects | Algorithms Blood Flow Velocity - physiology Blood Viscosity - physiology Cell Movement Cell-free layer Cell-Free System Computer Simulation Erythrocytes - cytology Erythrocytes - physiology Hematocrit Hemodynamics Humans Lift force Mesoscopic simulation Microcirculation Microcirculation - physiology Microvessels - physiology Models, Biological Models, Cardiovascular Motion Shear-induced pressure Smoothed dissipative particle dynamics Viscosity |
| title | Microvascular blood flow resistance: Role of red blood cell migration and dispersion |
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