Norepinephrine and corticosterone in the medial prefrontal cortex and hippocampus predict PTSD-like symptoms in mice

This study measured changes in brain extracellular norepinephrine (NE) and free corticosterone (CORT) levels in a mouse model of post‐traumatic stress disorder and related them to hyperarousal and fear memory retention. To this end, microdialysis in the medial prefrontal cortex (mPFC) and the hippoc...

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Veröffentlicht in:	The European journal of neuroscience 2015-05, Vol.41 (9), p.1139-1148
Hauptverfasser:	Kao, C.-Y., Stalla, G., Stalla, J., Wotjak, C. T., Anderzhanova, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal model Animals Arousal corticosterone Corticosterone - metabolism Extracellular Space - metabolism Fear forebrain Hippocampus - metabolism Hippocampus - physiopathology Male Mice Mice, Inbred C57BL norepinephrine Norepinephrine - metabolism Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology PTSD Reflex, Startle Stress Disorders, Post-Traumatic - metabolism Stress Disorders, Post-Traumatic - physiopathology
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