Ocular Surface Reconstruction With Keratolimbal Allograft for the Treatment of Severe or Recurrent Symblepharon
PURPOSE:To describe an ocular surface reconstruction technique using keratolimbal allograft (KLAL) tissue to repair and treat severe or recurrent symblepharon. METHODS:Five eyes of 5 patients (age 23–71 years) with severe or recurrent symblepharon causing symptomatic restrictive diplopia in primary...
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| Veröffentlicht in: | Cornea 2015-06, Vol.34 (6), p.632-636 |
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| creator | Farid, Marjan Lee, Nancy |
| description | PURPOSE:To describe an ocular surface reconstruction technique using keratolimbal allograft (KLAL) tissue to repair and treat severe or recurrent symblepharon.
METHODS:Five eyes of 5 patients (age 23–71 years) with severe or recurrent symblepharon causing symptomatic restrictive diplopia in primary gaze have been treated. After meticulous symblepharon lysis and scar tissue removal, KLAL tissue was sutured onto the ocular surface and used as a spacer to prevent recurrent scar formation. Patients have been followed from 12 to 28 months.
RESULTS:All eyes have been free of symblepharon recurrence in areas reconstructed with KLAL tissues. Mild recurrences of adhesions have occurred in areas posterior to the KLAL graft and none have recurred over the KLAL segments. Primary gaze diplopia has been resolved in all cases with only mild residual diplopia in extreme lateral gazes for 3 patients.
CONCLUSIONS:Ocular surface reconstruction with KLAL tissue effectively achieves functional and anatomic success in fornix repair for patients with severe or recurrent symblepharon. Donor KLAL is a robust tissue alternative to traditional amniotic membrane or conjunctival autografts. |
| doi_str_mv | 10.1097/ICO.0000000000000423 |
| format | Article |
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METHODS:Five eyes of 5 patients (age 23–71 years) with severe or recurrent symblepharon causing symptomatic restrictive diplopia in primary gaze have been treated. After meticulous symblepharon lysis and scar tissue removal, KLAL tissue was sutured onto the ocular surface and used as a spacer to prevent recurrent scar formation. Patients have been followed from 12 to 28 months.
RESULTS:All eyes have been free of symblepharon recurrence in areas reconstructed with KLAL tissues. Mild recurrences of adhesions have occurred in areas posterior to the KLAL graft and none have recurred over the KLAL segments. Primary gaze diplopia has been resolved in all cases with only mild residual diplopia in extreme lateral gazes for 3 patients.
CONCLUSIONS:Ocular surface reconstruction with KLAL tissue effectively achieves functional and anatomic success in fornix repair for patients with severe or recurrent symblepharon. Donor KLAL is a robust tissue alternative to traditional amniotic membrane or conjunctival autografts.</description><identifier>ISSN: 0277-3740</identifier><identifier>EISSN: 1536-4798</identifier><identifier>DOI: 10.1097/ICO.0000000000000423</identifier><identifier>PMID: 25811723</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Aged ; Allografts ; Cell Transplantation ; Conjunctival Diseases - pathology ; Conjunctival Diseases - surgery ; Diplopia - physiopathology ; Eyelid Diseases - pathology ; Eyelid Diseases - surgery ; Female ; Fibrin Tissue Adhesive - therapeutic use ; Follow-Up Studies ; Humans ; Limbus Corneae - cytology ; Male ; Middle Aged ; Reconstructive Surgical Procedures ; Recurrence ; Retrospective Studies ; Suture Techniques ; Tissue Adhesions - surgery ; Tissue Adhesives - therapeutic use ; Young Adult</subject><ispartof>Cornea, 2015-06, Vol.34 (6), p.632-636</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3563-108f925585f86fed21a117640bfde57337e110871f84c3ede88c66137d62d8d73</citedby><cites>FETCH-LOGICAL-c3563-108f925585f86fed21a117640bfde57337e110871f84c3ede88c66137d62d8d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25811723$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Farid, Marjan</creatorcontrib><creatorcontrib>Lee, Nancy</creatorcontrib><title>Ocular Surface Reconstruction With Keratolimbal Allograft for the Treatment of Severe or Recurrent Symblepharon</title><title>Cornea</title><addtitle>Cornea</addtitle><description>PURPOSE:To describe an ocular surface reconstruction technique using keratolimbal allograft (KLAL) tissue to repair and treat severe or recurrent symblepharon.
METHODS:Five eyes of 5 patients (age 23–71 years) with severe or recurrent symblepharon causing symptomatic restrictive diplopia in primary gaze have been treated. After meticulous symblepharon lysis and scar tissue removal, KLAL tissue was sutured onto the ocular surface and used as a spacer to prevent recurrent scar formation. Patients have been followed from 12 to 28 months.
RESULTS:All eyes have been free of symblepharon recurrence in areas reconstructed with KLAL tissues. Mild recurrences of adhesions have occurred in areas posterior to the KLAL graft and none have recurred over the KLAL segments. Primary gaze diplopia has been resolved in all cases with only mild residual diplopia in extreme lateral gazes for 3 patients.
CONCLUSIONS:Ocular surface reconstruction with KLAL tissue effectively achieves functional and anatomic success in fornix repair for patients with severe or recurrent symblepharon. Donor KLAL is a robust tissue alternative to traditional amniotic membrane or conjunctival autografts.</description><subject>Adult</subject><subject>Aged</subject><subject>Allografts</subject><subject>Cell Transplantation</subject><subject>Conjunctival Diseases - pathology</subject><subject>Conjunctival Diseases - surgery</subject><subject>Diplopia - physiopathology</subject><subject>Eyelid Diseases - pathology</subject><subject>Eyelid Diseases - surgery</subject><subject>Female</subject><subject>Fibrin Tissue Adhesive - therapeutic use</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Limbus Corneae - cytology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Reconstructive Surgical Procedures</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Suture Techniques</subject><subject>Tissue Adhesions - surgery</subject><subject>Tissue Adhesives - therapeutic use</subject><subject>Young Adult</subject><issn>0277-3740</issn><issn>1536-4798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQha2qqCxL_wGqfOwl1I4T23tEKygrkFbqgjhGXmfcpHXiZeyA9t_XaAFVPXQuI818783oEXLG2TlnC_VttVyfs7-rKsUHMuO1kEWlFvojmbFSqUKoih2Tkxh_ZUYpWX4ix2WtOVelmJGwtpM3SDcTOmOB_gAbxphwsqkPI33oU0dvAE0Kvh-2xtML78NPNC5RF5CmDugdgkkDjIkGRzfwBAg0r7LThPgy3uyHrYddZzCMp-TIGR_h82ufk_ury7vldXG7_r5aXtwWVtRSFJxptyjrWtdOSwdtyU1-WFZs61qolRAKeGYUd7qyAlrQ2krJhWpl2epWiTn5evDdYXicIKZm6KMF780IYYoNl5pxpVS1yGh1QC2GGBFcs8N-MLhvOGteom5y1M2_UWfZl9cL03aA9l30lm0G9AF4Dj4Bxt9-egZsOjA-df_3_gMJc4sQ</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Farid, Marjan</creator><creator>Lee, Nancy</creator><general>Copyright Wolters Kluwer Health, Inc. All rights reserved</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201506</creationdate><title>Ocular Surface Reconstruction With Keratolimbal Allograft for the Treatment of Severe or Recurrent Symblepharon</title><author>Farid, Marjan ; Lee, Nancy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3563-108f925585f86fed21a117640bfde57337e110871f84c3ede88c66137d62d8d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Allografts</topic><topic>Cell Transplantation</topic><topic>Conjunctival Diseases - pathology</topic><topic>Conjunctival Diseases - surgery</topic><topic>Diplopia - physiopathology</topic><topic>Eyelid Diseases - pathology</topic><topic>Eyelid Diseases - surgery</topic><topic>Female</topic><topic>Fibrin Tissue Adhesive - therapeutic use</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Limbus Corneae - cytology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Reconstructive Surgical Procedures</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Suture Techniques</topic><topic>Tissue Adhesions - surgery</topic><topic>Tissue Adhesives - therapeutic use</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farid, Marjan</creatorcontrib><creatorcontrib>Lee, Nancy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cornea</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farid, Marjan</au><au>Lee, Nancy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ocular Surface Reconstruction With Keratolimbal Allograft for the Treatment of Severe or Recurrent Symblepharon</atitle><jtitle>Cornea</jtitle><addtitle>Cornea</addtitle><date>2015-06</date><risdate>2015</risdate><volume>34</volume><issue>6</issue><spage>632</spage><epage>636</epage><pages>632-636</pages><issn>0277-3740</issn><eissn>1536-4798</eissn><abstract>PURPOSE:To describe an ocular surface reconstruction technique using keratolimbal allograft (KLAL) tissue to repair and treat severe or recurrent symblepharon.
METHODS:Five eyes of 5 patients (age 23–71 years) with severe or recurrent symblepharon causing symptomatic restrictive diplopia in primary gaze have been treated. After meticulous symblepharon lysis and scar tissue removal, KLAL tissue was sutured onto the ocular surface and used as a spacer to prevent recurrent scar formation. Patients have been followed from 12 to 28 months.
RESULTS:All eyes have been free of symblepharon recurrence in areas reconstructed with KLAL tissues. Mild recurrences of adhesions have occurred in areas posterior to the KLAL graft and none have recurred over the KLAL segments. Primary gaze diplopia has been resolved in all cases with only mild residual diplopia in extreme lateral gazes for 3 patients.
CONCLUSIONS:Ocular surface reconstruction with KLAL tissue effectively achieves functional and anatomic success in fornix repair for patients with severe or recurrent symblepharon. Donor KLAL is a robust tissue alternative to traditional amniotic membrane or conjunctival autografts.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>25811723</pmid><doi>10.1097/ICO.0000000000000423</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Allografts Cell Transplantation Conjunctival Diseases - pathology Conjunctival Diseases - surgery Diplopia - physiopathology Eyelid Diseases - pathology Eyelid Diseases - surgery Female Fibrin Tissue Adhesive - therapeutic use Follow-Up Studies Humans Limbus Corneae - cytology Male Middle Aged Reconstructive Surgical Procedures Recurrence Retrospective Studies Suture Techniques Tissue Adhesions - surgery Tissue Adhesives - therapeutic use Young Adult |
| title | Ocular Surface Reconstruction With Keratolimbal Allograft for the Treatment of Severe or Recurrent Symblepharon |
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