Treatment of personality disorder
Summary The evidence base for the effective treatment of personality disorders is insufficient. Most of the existing evidence on personality disorder is for the treatment of borderline personality disorder, but even this is limited by the small sample sizes and short follow-up in clinical trials, th...
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| Veröffentlicht in: | The Lancet (British edition) 2015-02, Vol.385 (9969), p.735-743 |
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| creator | Bateman, Anthony W, Prof Gunderson, John, Prof Mulder, Roger, Prof |
| description | Summary The evidence base for the effective treatment of personality disorders is insufficient. Most of the existing evidence on personality disorder is for the treatment of borderline personality disorder, but even this is limited by the small sample sizes and short follow-up in clinical trials, the wide range of core outcome measures used by studies, and poor control of coexisting psychopathology. Psychological or psychosocial intervention is recommended as the primary treatment for borderline personality disorder and pharmacotherapy is only advised as an adjunctive treatment. The amount of research about the underlying, abnormal, psychological or biological processes leading to the manifestation of a disordered personality is increasing, which could lead to more effective interventions. The synergistic or antagonistic interaction of psychotherapies and drugs for treating personality disorder should be studied in conjunction with their mechanisms of change throughout the development of each. |
| doi_str_mv | 10.1016/S0140-6736(14)61394-5 |
| format | Article |
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Most of the existing evidence on personality disorder is for the treatment of borderline personality disorder, but even this is limited by the small sample sizes and short follow-up in clinical trials, the wide range of core outcome measures used by studies, and poor control of coexisting psychopathology. Psychological or psychosocial intervention is recommended as the primary treatment for borderline personality disorder and pharmacotherapy is only advised as an adjunctive treatment. The amount of research about the underlying, abnormal, psychological or biological processes leading to the manifestation of a disordered personality is increasing, which could lead to more effective interventions. The synergistic or antagonistic interaction of psychotherapies and drugs for treating personality disorder should be studied in conjunction with their mechanisms of change throughout the development of each.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(14)61394-5</identifier><identifier>PMID: 25706219</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antipsychotic Agents - therapeutic use ; Borderline Personality Disorder - drug therapy ; Borderline Personality Disorder - therapy ; Drug therapy ; Evidence-Based Medicine ; Humans ; Internal Medicine ; Medical treatment ; Mental disorders ; Monoamine Oxidase Inhibitors - therapeutic use ; Patients ; Personality ; Personality disorders ; Personality Disorders - classification ; Personality Disorders - therapy ; Psychotherapy ; Serotonin Uptake Inhibitors - therapeutic use ; Studies ; Treatment Outcome</subject><ispartof>The Lancet (British edition), 2015-02, Vol.385 (9969), p.735-743</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Feb 21, 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-229b1ff8f338dc48bd3d2117aeca86d2eff3838bda0b3d07afd8e91539286ea13</citedby><cites>FETCH-LOGICAL-c481t-229b1ff8f338dc48bd3d2117aeca86d2eff3838bda0b3d07afd8e91539286ea13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1656441014?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25706219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bateman, Anthony W, Prof</creatorcontrib><creatorcontrib>Gunderson, John, Prof</creatorcontrib><creatorcontrib>Mulder, Roger, Prof</creatorcontrib><title>Treatment of personality disorder</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Summary The evidence base for the effective treatment of personality disorders is insufficient. Most of the existing evidence on personality disorder is for the treatment of borderline personality disorder, but even this is limited by the small sample sizes and short follow-up in clinical trials, the wide range of core outcome measures used by studies, and poor control of coexisting psychopathology. Psychological or psychosocial intervention is recommended as the primary treatment for borderline personality disorder and pharmacotherapy is only advised as an adjunctive treatment. The amount of research about the underlying, abnormal, psychological or biological processes leading to the manifestation of a disordered personality is increasing, which could lead to more effective interventions. The synergistic or antagonistic interaction of psychotherapies and drugs for treating personality disorder should be studied in conjunction with their mechanisms of change throughout the development of each.</description><subject>Antipsychotic Agents - therapeutic use</subject><subject>Borderline Personality Disorder - drug therapy</subject><subject>Borderline Personality Disorder - therapy</subject><subject>Drug therapy</subject><subject>Evidence-Based Medicine</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medical treatment</subject><subject>Mental disorders</subject><subject>Monoamine Oxidase Inhibitors - therapeutic use</subject><subject>Patients</subject><subject>Personality</subject><subject>Personality disorders</subject><subject>Personality Disorders - classification</subject><subject>Personality Disorders - therapy</subject><subject>Psychotherapy</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Studies</subject><subject>Treatment Outcome</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkMtKAzEUhoMoWi-PoFTc6GI0J8lkMhtFxBsILlRwF9LkBKLTmZpMhb69aesF3Ogq4fCd__B_hOwCPQYK8uSBgqCFrLg8BHEkgdeiKFfIAESVP6J6XiWDb2SDbKb0QikVkpbrZIOVFZUM6gHZf4xo-jG2_bDzwwnG1LWmCf1s6ELqosO4Tda8aRLufL5b5Onq8vHipri7v769OL8rrFDQF4zVI_Beec6Vy6OR444BVAatUdIx9J4rnseGjrijlfFOYQ0lr5mSaIBvkcNl7iR2b1NMvR6HZLFpTIvdNGmQKvdWtaj_gZZK5ONsnnrwC33ppjFXXFBSiCxTZKpcUjZ2KUX0ehLD2MSZBqrnuvVCt5671CD0Qrcu897eZ_p0NEb3vfXlNwNnSwCzufeAUScbsLXoQkTba9eFP0-c_kqwTWiDNc0rzjD9tNGJaboMmWeAWCSU_AO1-KGZ</recordid><startdate>20150221</startdate><enddate>20150221</enddate><creator>Bateman, Anthony W, Prof</creator><creator>Gunderson, John, Prof</creator><creator>Mulder, Roger, Prof</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TT</scope><scope>0TZ</scope><scope>0U~</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88C</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8C2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ASE</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FPQ</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K6X</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>KB~</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20150221</creationdate><title>Treatment of personality disorder</title><author>Bateman, Anthony W, Prof ; Gunderson, John, Prof ; Mulder, Roger, Prof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-229b1ff8f338dc48bd3d2117aeca86d2eff3838bda0b3d07afd8e91539286ea13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Antipsychotic Agents - therapeutic use</topic><topic>Borderline Personality Disorder - drug therapy</topic><topic>Borderline Personality Disorder - therapy</topic><topic>Drug therapy</topic><topic>Evidence-Based Medicine</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medical treatment</topic><topic>Mental disorders</topic><topic>Monoamine Oxidase Inhibitors - therapeutic use</topic><topic>Patients</topic><topic>Personality</topic><topic>Personality disorders</topic><topic>Personality Disorders - classification</topic><topic>Personality Disorders - therapy</topic><topic>Psychotherapy</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>Studies</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bateman, Anthony W, Prof</creatorcontrib><creatorcontrib>Gunderson, John, Prof</creatorcontrib><creatorcontrib>Mulder, Roger, Prof</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>News PRO</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Global News & ABI/Inform Professional</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Lancet Titles</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>British Nursing Index</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>British Nursing Index</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Newsstand Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bateman, Anthony W, Prof</au><au>Gunderson, John, Prof</au><au>Mulder, Roger, Prof</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of personality disorder</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>2015-02-21</date><risdate>2015</risdate><volume>385</volume><issue>9969</issue><spage>735</spage><epage>743</epage><pages>735-743</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Summary The evidence base for the effective treatment of personality disorders is insufficient. Most of the existing evidence on personality disorder is for the treatment of borderline personality disorder, but even this is limited by the small sample sizes and short follow-up in clinical trials, the wide range of core outcome measures used by studies, and poor control of coexisting psychopathology. Psychological or psychosocial intervention is recommended as the primary treatment for borderline personality disorder and pharmacotherapy is only advised as an adjunctive treatment. The amount of research about the underlying, abnormal, psychological or biological processes leading to the manifestation of a disordered personality is increasing, which could lead to more effective interventions. The synergistic or antagonistic interaction of psychotherapies and drugs for treating personality disorder should be studied in conjunction with their mechanisms of change throughout the development of each.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>25706219</pmid><doi>10.1016/S0140-6736(14)61394-5</doi><tpages>9</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 2015-02, Vol.385 (9969), p.735-743 |
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| subjects | Antipsychotic Agents - therapeutic use Borderline Personality Disorder - drug therapy Borderline Personality Disorder - therapy Drug therapy Evidence-Based Medicine Humans Internal Medicine Medical treatment Mental disorders Monoamine Oxidase Inhibitors - therapeutic use Patients Personality Personality disorders Personality Disorders - classification Personality Disorders - therapy Psychotherapy Serotonin Uptake Inhibitors - therapeutic use Studies Treatment Outcome |
| title | Treatment of personality disorder |
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