Alterations in the topoisomerase IIα gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase IIβ enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line

A human HL-60 leukemia cell line selected for resistance to mitoxantrone, HL-60/MX2, displays cross-resistance only to agents whose cytotoxicities result from interaction with the nuclear enzyme DNA topoisomerase II (topo II). The topo II catalytic activity is reduced 2-fold in the drug-resistant ce...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1995-04, Vol.55 (8), p.1707-1716
Hauptverfasser:	HARKER, W. G, SLADE, D. L, PARR, R. L, FELDHOFF, P. W, SULLIVAN, D. M, HOLGUIN, M. H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Base Sequence Biological and medical sciences Cell Line DNA Primers DNA Topoisomerases, Type II - analysis DNA Topoisomerases, Type II - biosynthesis DNA Topoisomerases, Type II - metabolism DNA, Neoplasm - isolation & purification DNA, Neoplasm - metabolism Drug Resistance Gene Expression General aspects Humans Isoenzymes - analysis Isoenzymes - biosynthesis Isoenzymes - metabolism Kinetics Leukemia, Promyelocytic, Acute Medical sciences Methylation Mitoxantrone - toxicity Molecular Sequence Data Molecular Weight Pharmacology. Drug treatments Polymerase Chain Reaction Restriction Mapping RNA, Messenger - biosynthesis Subcellular Fractions - enzymology Transcription, Genetic Tumor Cells, Cultured
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