Induction of apolipoprotein E expression during erythroid differentiation of human K562 leukemia cells
Apolipoprotein E (ApoE) is the only apolipoprotein that is expressed in extrahepatic tissues. ApoE expression was studied in leukemia K562 cells differentiated towards erythroid or myelomonocytic lineages. When K562 cells were differentiated into the erythroid lineage by addition either of 1-β- d-ar...
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| Veröffentlicht in: | Leukemia research 1993-09, Vol.17 (9), p.771-776 |
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| container_title | Leukemia research |
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| creator | Crespo, Piero Delgado, M.Dolores Gómez-Casares, M.Teresa Cuadrado, M.Angeles Richard, Carlos León, Javier |
| description | Apolipoprotein E (ApoE) is the only apolipoprotein that is expressed in extrahepatic tissues. ApoE expression was studied in leukemia K562 cells differentiated towards erythroid or myelomonocytic lineages. When K562 cells were differentiated into the erythroid lineage by addition either of 1-β-
d-arabinofuranosylcytosine or hydroxyurea, an increase in ApoE mRNA and protein was detected. A weaker ApoE induction was also observed during phorbol ester-induced myelomonocytic differentiation. Previous work has associated ApoE expression to monocytic differentiation. The findings reported here indicate that ApoE overexpression is not associated with a specific lineage in myeloid differentiation and that may play a role in erythroid differentiation. |
| doi_str_mv | 10.1016/0145-2126(93)90111-W |
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d-arabinofuranosylcytosine or hydroxyurea, an increase in ApoE mRNA and protein was detected. A weaker ApoE induction was also observed during phorbol ester-induced myelomonocytic differentiation. Previous work has associated ApoE expression to monocytic differentiation. The findings reported here indicate that ApoE overexpression is not associated with a specific lineage in myeloid differentiation and that may play a role in erythroid differentiation.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/0145-2126(93)90111-W</identifier><identifier>PMID: 8371577</identifier><identifier>CODEN: LEREDD</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Apolipoprotein E ; Apolipoproteins E - biosynthesis ; Apolipoproteins E - genetics ; Biological and medical sciences ; Cell Differentiation - drug effects ; Cytarabine - pharmacology ; erythroid differentiation ; Hematologic and hematopoietic diseases ; Humans ; hydroxyurea ; Hydroxyurea - pharmacology ; Hypercholesterolemia - blood ; K562 cells ; Leukemia, Erythroblastic, Acute - metabolism ; Leukemia, Erythroblastic, Acute - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; RNA, Messenger - analysis ; Tetradecanoylphorbol Acetate - pharmacology ; TPA ; Tumor Cells, Cultured ; β- d-arabinofuranosylcytosine</subject><ispartof>Leukemia research, 1993-09, Vol.17 (9), p.771-776</ispartof><rights>1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-59c12ccb0e4584abf65e3de4aabe7cd0f87386e48b98049d91c52176777c10f53</citedby><cites>FETCH-LOGICAL-c417t-59c12ccb0e4584abf65e3de4aabe7cd0f87386e48b98049d91c52176777c10f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/014521269390111W$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4889192$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8371577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crespo, Piero</creatorcontrib><creatorcontrib>Delgado, M.Dolores</creatorcontrib><creatorcontrib>Gómez-Casares, M.Teresa</creatorcontrib><creatorcontrib>Cuadrado, M.Angeles</creatorcontrib><creatorcontrib>Richard, Carlos</creatorcontrib><creatorcontrib>León, Javier</creatorcontrib><title>Induction of apolipoprotein E expression during erythroid differentiation of human K562 leukemia cells</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Apolipoprotein E (ApoE) is the only apolipoprotein that is expressed in extrahepatic tissues. ApoE expression was studied in leukemia K562 cells differentiated towards erythroid or myelomonocytic lineages. When K562 cells were differentiated into the erythroid lineage by addition either of 1-β-
d-arabinofuranosylcytosine or hydroxyurea, an increase in ApoE mRNA and protein was detected. A weaker ApoE induction was also observed during phorbol ester-induced myelomonocytic differentiation. Previous work has associated ApoE expression to monocytic differentiation. The findings reported here indicate that ApoE overexpression is not associated with a specific lineage in myeloid differentiation and that may play a role in erythroid differentiation.</description><subject>Apolipoprotein E</subject><subject>Apolipoproteins E - biosynthesis</subject><subject>Apolipoproteins E - genetics</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - drug effects</subject><subject>Cytarabine - pharmacology</subject><subject>erythroid differentiation</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>hydroxyurea</subject><subject>Hydroxyurea - pharmacology</subject><subject>Hypercholesterolemia - blood</subject><subject>K562 cells</subject><subject>Leukemia, Erythroblastic, Acute - metabolism</subject><subject>Leukemia, Erythroblastic, Acute - pathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>RNA, Messenger - analysis</subject><subject>Tetradecanoylphorbol Acetate - pharmacology</subject><subject>TPA</subject><subject>Tumor Cells, Cultured</subject><subject>β- d-arabinofuranosylcytosine</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1TAQRS1EVR6FPwDJC4RgkeJJ7NjeIKGqQNVK3YC6tBx7TA2JE-wE0b8n4T3ektUs7rmjmUPIC2DnwKB9x4CLqoa6faObt5oBQHX3iOxAyaYSqhGPye6IPCFPS_nOGBMa9Ck5VY0EIeWOhKvkFzfHMdExUDuNfZzGKY8zxkQvKf6eMpayxX7JMX2jmB_m-zxGT30MATOmOdp__ftlsIlei7amPS4_cIiWOuz78oycBNsXfH6YZ-Trx8svF5-rm9tPVxcfbirHQc6V0A5q5zqGXChuu9AKbDxyazuUzrOw_qZa5KrTinHtNThRg2yllA5YEM0Zeb3fu77wc8EymyGW7QKbcFyKgVZqBVyvIN-DLo-lZAxmynGw-cEAM5tes7kzmzujG_NXr7lbay8P-5duQH8sHXyu-atDbouzfcg2uViOGFdq9V-v2Ps9hquLXxGzKS5icuhjRjcbP8b_3_EHCoGXgg</recordid><startdate>19930901</startdate><enddate>19930901</enddate><creator>Crespo, Piero</creator><creator>Delgado, M.Dolores</creator><creator>Gómez-Casares, M.Teresa</creator><creator>Cuadrado, M.Angeles</creator><creator>Richard, Carlos</creator><creator>León, Javier</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19930901</creationdate><title>Induction of apolipoprotein E expression during erythroid differentiation of human K562 leukemia cells</title><author>Crespo, Piero ; Delgado, M.Dolores ; Gómez-Casares, M.Teresa ; Cuadrado, M.Angeles ; Richard, Carlos ; León, Javier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-59c12ccb0e4584abf65e3de4aabe7cd0f87386e48b98049d91c52176777c10f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Apolipoprotein E</topic><topic>Apolipoproteins E - biosynthesis</topic><topic>Apolipoproteins E - genetics</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - drug effects</topic><topic>Cytarabine - pharmacology</topic><topic>erythroid differentiation</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>hydroxyurea</topic><topic>Hydroxyurea - pharmacology</topic><topic>Hypercholesterolemia - blood</topic><topic>K562 cells</topic><topic>Leukemia, Erythroblastic, Acute - metabolism</topic><topic>Leukemia, Erythroblastic, Acute - pathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>RNA, Messenger - analysis</topic><topic>Tetradecanoylphorbol Acetate - pharmacology</topic><topic>TPA</topic><topic>Tumor Cells, Cultured</topic><topic>β- d-arabinofuranosylcytosine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crespo, Piero</creatorcontrib><creatorcontrib>Delgado, M.Dolores</creatorcontrib><creatorcontrib>Gómez-Casares, M.Teresa</creatorcontrib><creatorcontrib>Cuadrado, M.Angeles</creatorcontrib><creatorcontrib>Richard, Carlos</creatorcontrib><creatorcontrib>León, Javier</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crespo, Piero</au><au>Delgado, M.Dolores</au><au>Gómez-Casares, M.Teresa</au><au>Cuadrado, M.Angeles</au><au>Richard, Carlos</au><au>León, Javier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of apolipoprotein E expression during erythroid differentiation of human K562 leukemia cells</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>1993-09-01</date><risdate>1993</risdate><volume>17</volume><issue>9</issue><spage>771</spage><epage>776</epage><pages>771-776</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>Apolipoprotein E (ApoE) is the only apolipoprotein that is expressed in extrahepatic tissues. ApoE expression was studied in leukemia K562 cells differentiated towards erythroid or myelomonocytic lineages. When K562 cells were differentiated into the erythroid lineage by addition either of 1-β-
d-arabinofuranosylcytosine or hydroxyurea, an increase in ApoE mRNA and protein was detected. A weaker ApoE induction was also observed during phorbol ester-induced myelomonocytic differentiation. Previous work has associated ApoE expression to monocytic differentiation. The findings reported here indicate that ApoE overexpression is not associated with a specific lineage in myeloid differentiation and that may play a role in erythroid differentiation.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8371577</pmid><doi>10.1016/0145-2126(93)90111-W</doi><tpages>6</tpages></addata></record> |
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| subjects | Apolipoprotein E Apolipoproteins E - biosynthesis Apolipoproteins E - genetics Biological and medical sciences Cell Differentiation - drug effects Cytarabine - pharmacology erythroid differentiation Hematologic and hematopoietic diseases Humans hydroxyurea Hydroxyurea - pharmacology Hypercholesterolemia - blood K562 cells Leukemia, Erythroblastic, Acute - metabolism Leukemia, Erythroblastic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences RNA, Messenger - analysis Tetradecanoylphorbol Acetate - pharmacology TPA Tumor Cells, Cultured β- d-arabinofuranosylcytosine |
| title | Induction of apolipoprotein E expression during erythroid differentiation of human K562 leukemia cells |
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