The role of free radicals in asbestos-induced diseases

Asbestos exposure causes pulmonary fibrosis and malignant neoplasms by mechanisms that remain uncertain. In this review, we explore the evidence supporting the hypothesis that free radicals and other reactive oxygen species (ROS) are an important mechanism by which asbestos mediates tissue damage. T...

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Veröffentlicht in:	Free Radical Biology and Medicine 1992, Vol.12 (4), p.293-315
Hauptverfasser:	Kamp, David W., Graceffa, Philip, Pryor, William A., Weitzman, Sigmund A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antioxidants Asbestos Asbestos - adverse effects Asbestos - chemistry Asbestos - pharmacology Asbestosis - etiology Biological and medical sciences Cancer Cigarette smoke and tar DNA Damage Free Radicals Humans Hydrogen peroxide Hydroxyl radical Iron - metabolism Iron chelators Lipid Peroxidation - drug effects Lung Diseases - etiology Lung injury Medical sciences Neoplasms - etiology Oxidants Oxygen - metabolism Phagocytic cells Pneumology Reactive oxygen species Tumors of the respiratory system and mediastinum
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