Age-dependent Variation of Selenium-75 Biokinetics in Rat
Substantial levels of selenium-79 (79Se) in radioactive waste from the nuclear fuel cycle, may result in a significant collective dose commitment following release into the environment. Few data are available from which the effective dose equivalent among subgroups of the general population can be m...
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| Veröffentlicht in: | International journal of radiation biology 1993, Vol.64 (3), p.329-333 |
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| container_title | International journal of radiation biology |
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| creator | Archimbaud, Y. Grillon, G. Poncy, J.L. Masse, R. |
| description | Substantial levels of selenium-79 (79Se) in radioactive waste from the nuclear fuel cycle, may result in a significant collective dose commitment following release into the environment. Few data are available from which the effective dose equivalent among subgroups of the general population can be made. Accordingly, whole body retention and organ content were studied in neonate, adult and pregnant rat following oral contamination with 75Se. The results for whole-body retention conformed to a two-component exponential with terminal biological half-time of about 40, 30 and 20 days in adult male, neonate and pregnant rat, respectively. The highest concentrations of Se occurred in the liver, kidney, and testis. Influence of Se kinetics as a function of age and physiological development on dose estimates are discussed. Results were consistent with current dosimetric models but suggested that the testis should also be included. |
| doi_str_mv | 10.1080/09553009314551481 |
| format | Article |
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Few data are available from which the effective dose equivalent among subgroups of the general population can be made. Accordingly, whole body retention and organ content were studied in neonate, adult and pregnant rat following oral contamination with 75Se. The results for whole-body retention conformed to a two-component exponential with terminal biological half-time of about 40, 30 and 20 days in adult male, neonate and pregnant rat, respectively. The highest concentrations of Se occurred in the liver, kidney, and testis. Influence of Se kinetics as a function of age and physiological development on dose estimates are discussed. Results were consistent with current dosimetric models but suggested that the testis should also be included.</description><identifier>ISSN: 0955-3002</identifier><identifier>EISSN: 1362-3095</identifier><identifier>DOI: 10.1080/09553009314551481</identifier><identifier>PMID: 8105011</identifier><language>eng</language><publisher>London: Informa UK Ltd</publisher><subject>Administration, Oral ; Age Factors ; Animals ; Animals, Newborn - metabolism ; Biological and medical sciences ; Biological effects of radiation ; Female ; Fundamental and applied biological sciences. Psychology ; Ionizing radiations ; Kidney - metabolism ; Liver - metabolism ; Male ; Pregnancy ; Pregnancy, Animal - metabolism ; Radioactive Waste ; Rats ; Rats, Sprague-Dawley ; Selenium Radioisotopes - administration & dosage ; Selenium Radioisotopes - pharmacokinetics ; Testis - metabolism ; Tissues, organs and organisms biophysics</subject><ispartof>International journal of radiation biology, 1993, Vol.64 (3), p.329-333</ispartof><rights>1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1993</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-f1a25e7239201a2d70077ea35a08e17add893b96341aa093c3ae50e36c7758a83</citedby><cites>FETCH-LOGICAL-c376t-f1a25e7239201a2d70077ea35a08e17add893b96341aa093c3ae50e36c7758a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/09553009314551481$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/09553009314551481$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>315,781,785,4025,27927,27928,27929,59651,59757,60440,60546,61225,61260,61406,61441</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4907673$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8105011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Archimbaud, Y.</creatorcontrib><creatorcontrib>Grillon, G.</creatorcontrib><creatorcontrib>Poncy, J.L.</creatorcontrib><creatorcontrib>Masse, R.</creatorcontrib><title>Age-dependent Variation of Selenium-75 Biokinetics in Rat</title><title>International journal of radiation biology</title><addtitle>Int J Radiat Biol</addtitle><description>Substantial levels of selenium-79 (79Se) in radioactive waste from the nuclear fuel cycle, may result in a significant collective dose commitment following release into the environment. Few data are available from which the effective dose equivalent among subgroups of the general population can be made. Accordingly, whole body retention and organ content were studied in neonate, adult and pregnant rat following oral contamination with 75Se. The results for whole-body retention conformed to a two-component exponential with terminal biological half-time of about 40, 30 and 20 days in adult male, neonate and pregnant rat, respectively. The highest concentrations of Se occurred in the liver, kidney, and testis. Influence of Se kinetics as a function of age and physiological development on dose estimates are discussed. Results were consistent with current dosimetric models but suggested that the testis should also be included.</description><subject>Administration, Oral</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ionizing radiations</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - metabolism</subject><subject>Radioactive Waste</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Selenium Radioisotopes - administration & dosage</subject><subject>Selenium Radioisotopes - pharmacokinetics</subject><subject>Testis - metabolism</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0955-3002</issn><issn>1362-3095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFtLxDAQhYMoul5-gA9CH8S36qTZNC36soo3WBC8vZYxnWq0TdakRfz3ZtlVEMGnOXC-M8wcxnY5HHIo4AhKKQVAKfhYSj4u-AobcZFnqYjOKhvN_agh22CbIbxCVCCKdbZecJDA-YiVk2dKa5qRrcn2ySN6g71xNnFNckctWTN0qZLJqXFvxlJvdEiMTW6x32ZrDbaBdpZziz1cnN-fXaXTm8vrs8k01ULlfdpwzCSpTJQZRFkrAKUIhUQoiCus66IUT2UuxhwxfqIFkgQSuVZKFliILXaw2Dvz7n2g0FedCZraFi25IVQ8VyVXEiLIF6D2LgRPTTXzpkP_WXGo5nVVf-qKmb3l8uGpo_onsewn-vtLH4PGtvFotQk_2LgElSsRsZMFZmzjfIcfzrd11eNn6_x3Rvx3xfGv-Ath279o9FS9usHbWO8_P3wBMjyULQ</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Archimbaud, Y.</creator><creator>Grillon, G.</creator><creator>Poncy, J.L.</creator><creator>Masse, R.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1993</creationdate><title>Age-dependent Variation of Selenium-75 Biokinetics in Rat</title><author>Archimbaud, Y. ; Grillon, G. ; Poncy, J.L. ; Masse, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-f1a25e7239201a2d70077ea35a08e17add893b96341aa093c3ae50e36c7758a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Administration, Oral</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ionizing radiations</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - metabolism</topic><topic>Radioactive Waste</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Selenium Radioisotopes - administration & dosage</topic><topic>Selenium Radioisotopes - pharmacokinetics</topic><topic>Testis - metabolism</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Archimbaud, Y.</creatorcontrib><creatorcontrib>Grillon, G.</creatorcontrib><creatorcontrib>Poncy, J.L.</creatorcontrib><creatorcontrib>Masse, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>International journal of radiation biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Archimbaud, Y.</au><au>Grillon, G.</au><au>Poncy, J.L.</au><au>Masse, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-dependent Variation of Selenium-75 Biokinetics in Rat</atitle><jtitle>International journal of radiation biology</jtitle><addtitle>Int J Radiat Biol</addtitle><date>1993</date><risdate>1993</risdate><volume>64</volume><issue>3</issue><spage>329</spage><epage>333</epage><pages>329-333</pages><issn>0955-3002</issn><eissn>1362-3095</eissn><abstract>Substantial levels of selenium-79 (79Se) in radioactive waste from the nuclear fuel cycle, may result in a significant collective dose commitment following release into the environment. Few data are available from which the effective dose equivalent among subgroups of the general population can be made. Accordingly, whole body retention and organ content were studied in neonate, adult and pregnant rat following oral contamination with 75Se. The results for whole-body retention conformed to a two-component exponential with terminal biological half-time of about 40, 30 and 20 days in adult male, neonate and pregnant rat, respectively. The highest concentrations of Se occurred in the liver, kidney, and testis. Influence of Se kinetics as a function of age and physiological development on dose estimates are discussed. Results were consistent with current dosimetric models but suggested that the testis should also be included.</abstract><cop>London</cop><pub>Informa UK Ltd</pub><pmid>8105011</pmid><doi>10.1080/09553009314551481</doi><tpages>5</tpages></addata></record> |
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| ispartof | International journal of radiation biology, 1993, Vol.64 (3), p.329-333 |
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| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Administration, Oral Age Factors Animals Animals, Newborn - metabolism Biological and medical sciences Biological effects of radiation Female Fundamental and applied biological sciences. Psychology Ionizing radiations Kidney - metabolism Liver - metabolism Male Pregnancy Pregnancy, Animal - metabolism Radioactive Waste Rats Rats, Sprague-Dawley Selenium Radioisotopes - administration & dosage Selenium Radioisotopes - pharmacokinetics Testis - metabolism Tissues, organs and organisms biophysics |
| title | Age-dependent Variation of Selenium-75 Biokinetics in Rat |
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