The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances
Recent findings suggest that the ability of melatonin to enter all body tissues and to be metabolized, enzymatically or nonenzymatically, in any of them results in a spectrum of effects, which exceed substantially those transduced by membrane receptors. These actions comprise the formation of variou...
Gespeichert in:
| Veröffentlicht in: | Neuroscience and biobehavioral reviews 1993, Vol.17 (3), p.347-357 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 357 |
|---|---|
| container_issue | 3 |
| container_start_page | 347 |
| container_title | Neuroscience and biobehavioral reviews |
| container_volume | 17 |
| creator | Hardeland, R. Reiter, R.J. Poeggeler, B. Tan, D.-X. |
| description | Recent findings suggest that the ability of melatonin to enter all body tissues and to be metabolized, enzymatically or nonenzymatically, in any of them results in a spectrum of effects, which exceed substantially those transduced by membrane receptors. These actions comprise the formation of various bioactive compounds such as
N-acetylserotonin, 5-methoxytryptamine,
N,N-dimethyl-5-methoxytryptamine, 5-methoxytrytophol, cyclic 2-hydroxymelatonin, pinoline, and 5-methoxylated kynuramines. Apart from enzymatic metabolism, nonenzymatic reactions with free radicals, in particular the superoxide anion and the hydroxyl radical, represent a new and significant aspect of melatonin's biological role. Melatonin represents the most potent physiological scavenger of hydroxyl radicals found to date, and recent findings suggest an essential role of this indoleamine for protection from hydroxyl radical-induced carcinogenesis and neurodegeneration. |
| doi_str_mv | 10.1016/S0149-7634(05)80016-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16789747</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0149763405800168</els_id><sourcerecordid>16789747</sourcerecordid><originalsourceid>FETCH-LOGICAL-c538t-84b535f17bbccebd0b057dae3f8c01e412215ff7be28ed3591b59429d71fded3</originalsourceid><addsrcrecordid>eNqFkE1vFSEUhonR1NvqT2gyi6axi1FghoHppmkaW02auPDuCR8Hi5mBFpim7vzpcj96t64I73kO5_AgdErwZ4LJ8OUnJv3Y8qHrP2F2IXDNWvEGrYjgXcsZFW_R6oC8R8c5_8YYU9yxI3QkKKdUDCv0d_0ATfa_gnfeqGCgia4pNZuhKB0nn-fXJMCS4kNMcwyb8qRKDD5cNteh-PjirSr-GZrHFAuYmoRGBdu4yqvtrb6ifVRmS-VF57IZlz-gd05NGT7uzxO0vv26vvnW3v-4-35zfd8a1onSil6zjjnCtTYGtMUaM24VdE4YTKAnlBLmHNdABdiOjUSzsaej5cTZGpyg892zdb-nBXKRs88GpkkFiEuWZOBi5D2vINuBJsWcEzj5mPys0h9JsNyIl1vxcmNVYia34qWofaf7AYuewR669qZr_WxfV9moyaX6e58PWMfZIDCt2NUOg-ri2UOS2XiooqxPVau00f9nkX9yfqMp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16789747</pqid></control><display><type>article</type><title>The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Hardeland, R. ; Reiter, R.J. ; Poeggeler, B. ; Tan, D.-X.</creator><creatorcontrib>Hardeland, R. ; Reiter, R.J. ; Poeggeler, B. ; Tan, D.-X.</creatorcontrib><description>Recent findings suggest that the ability of melatonin to enter all body tissues and to be metabolized, enzymatically or nonenzymatically, in any of them results in a spectrum of effects, which exceed substantially those transduced by membrane receptors. These actions comprise the formation of various bioactive compounds such as
N-acetylserotonin, 5-methoxytryptamine,
N,N-dimethyl-5-methoxytryptamine, 5-methoxytrytophol, cyclic 2-hydroxymelatonin, pinoline, and 5-methoxylated kynuramines. Apart from enzymatic metabolism, nonenzymatic reactions with free radicals, in particular the superoxide anion and the hydroxyl radical, represent a new and significant aspect of melatonin's biological role. Melatonin represents the most potent physiological scavenger of hydroxyl radicals found to date, and recent findings suggest an essential role of this indoleamine for protection from hydroxyl radical-induced carcinogenesis and neurodegeneration.</description><identifier>ISSN: 0149-7634</identifier><identifier>EISSN: 1873-7528</identifier><identifier>DOI: 10.1016/S0149-7634(05)80016-8</identifier><identifier>PMID: 8272286</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aging ; Animals ; Biological and medical sciences ; Carcinogenesis ; Development. Metamorphosis. Moult. Ageing ; Free Radical Scavengers ; Free radicals ; Fundamental and applied biological sciences. Psychology ; Humans ; Hydroxyl Radical - metabolism ; Indoleamines ; Kynuramines ; Melatonin - metabolism ; Melatonin - physiology ; Pineal gland ; Psychotogens ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; β-Carbolines</subject><ispartof>Neuroscience and biobehavioral reviews, 1993, Vol.17 (3), p.347-357</ispartof><rights>1993 Pergamon Press Ltd.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-84b535f17bbccebd0b057dae3f8c01e412215ff7be28ed3591b59429d71fded3</citedby><cites>FETCH-LOGICAL-c538t-84b535f17bbccebd0b057dae3f8c01e412215ff7be28ed3591b59429d71fded3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0149763405800168$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3756802$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8272286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hardeland, R.</creatorcontrib><creatorcontrib>Reiter, R.J.</creatorcontrib><creatorcontrib>Poeggeler, B.</creatorcontrib><creatorcontrib>Tan, D.-X.</creatorcontrib><title>The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances</title><title>Neuroscience and biobehavioral reviews</title><addtitle>Neurosci Biobehav Rev</addtitle><description>Recent findings suggest that the ability of melatonin to enter all body tissues and to be metabolized, enzymatically or nonenzymatically, in any of them results in a spectrum of effects, which exceed substantially those transduced by membrane receptors. These actions comprise the formation of various bioactive compounds such as
N-acetylserotonin, 5-methoxytryptamine,
N,N-dimethyl-5-methoxytryptamine, 5-methoxytrytophol, cyclic 2-hydroxymelatonin, pinoline, and 5-methoxylated kynuramines. Apart from enzymatic metabolism, nonenzymatic reactions with free radicals, in particular the superoxide anion and the hydroxyl radical, represent a new and significant aspect of melatonin's biological role. Melatonin represents the most potent physiological scavenger of hydroxyl radicals found to date, and recent findings suggest an essential role of this indoleamine for protection from hydroxyl radical-induced carcinogenesis and neurodegeneration.</description><subject>Aging</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis</subject><subject>Development. Metamorphosis. Moult. Ageing</subject><subject>Free Radical Scavengers</subject><subject>Free radicals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hydroxyl Radical - metabolism</subject><subject>Indoleamines</subject><subject>Kynuramines</subject><subject>Melatonin - metabolism</subject><subject>Melatonin - physiology</subject><subject>Pineal gland</subject><subject>Psychotogens</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>β-Carbolines</subject><issn>0149-7634</issn><issn>1873-7528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1vFSEUhonR1NvqT2gyi6axi1FghoHppmkaW02auPDuCR8Hi5mBFpim7vzpcj96t64I73kO5_AgdErwZ4LJ8OUnJv3Y8qHrP2F2IXDNWvEGrYjgXcsZFW_R6oC8R8c5_8YYU9yxI3QkKKdUDCv0d_0ATfa_gnfeqGCgia4pNZuhKB0nn-fXJMCS4kNMcwyb8qRKDD5cNteh-PjirSr-GZrHFAuYmoRGBdu4yqvtrb6ifVRmS-VF57IZlz-gd05NGT7uzxO0vv26vvnW3v-4-35zfd8a1onSil6zjjnCtTYGtMUaM24VdE4YTKAnlBLmHNdABdiOjUSzsaej5cTZGpyg892zdb-nBXKRs88GpkkFiEuWZOBi5D2vINuBJsWcEzj5mPys0h9JsNyIl1vxcmNVYia34qWofaf7AYuewR669qZr_WxfV9moyaX6e58PWMfZIDCt2NUOg-ri2UOS2XiooqxPVau00f9nkX9yfqMp</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Hardeland, R.</creator><creator>Reiter, R.J.</creator><creator>Poeggeler, B.</creator><creator>Tan, D.-X.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>1993</creationdate><title>The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances</title><author>Hardeland, R. ; Reiter, R.J. ; Poeggeler, B. ; Tan, D.-X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-84b535f17bbccebd0b057dae3f8c01e412215ff7be28ed3591b59429d71fded3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis</topic><topic>Development. Metamorphosis. Moult. Ageing</topic><topic>Free Radical Scavengers</topic><topic>Free radicals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hydroxyl Radical - metabolism</topic><topic>Indoleamines</topic><topic>Kynuramines</topic><topic>Melatonin - metabolism</topic><topic>Melatonin - physiology</topic><topic>Pineal gland</topic><topic>Psychotogens</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>β-Carbolines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hardeland, R.</creatorcontrib><creatorcontrib>Reiter, R.J.</creatorcontrib><creatorcontrib>Poeggeler, B.</creatorcontrib><creatorcontrib>Tan, D.-X.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience and biobehavioral reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hardeland, R.</au><au>Reiter, R.J.</au><au>Poeggeler, B.</au><au>Tan, D.-X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances</atitle><jtitle>Neuroscience and biobehavioral reviews</jtitle><addtitle>Neurosci Biobehav Rev</addtitle><date>1993</date><risdate>1993</risdate><volume>17</volume><issue>3</issue><spage>347</spage><epage>357</epage><pages>347-357</pages><issn>0149-7634</issn><eissn>1873-7528</eissn><abstract>Recent findings suggest that the ability of melatonin to enter all body tissues and to be metabolized, enzymatically or nonenzymatically, in any of them results in a spectrum of effects, which exceed substantially those transduced by membrane receptors. These actions comprise the formation of various bioactive compounds such as
N-acetylserotonin, 5-methoxytryptamine,
N,N-dimethyl-5-methoxytryptamine, 5-methoxytrytophol, cyclic 2-hydroxymelatonin, pinoline, and 5-methoxylated kynuramines. Apart from enzymatic metabolism, nonenzymatic reactions with free radicals, in particular the superoxide anion and the hydroxyl radical, represent a new and significant aspect of melatonin's biological role. Melatonin represents the most potent physiological scavenger of hydroxyl radicals found to date, and recent findings suggest an essential role of this indoleamine for protection from hydroxyl radical-induced carcinogenesis and neurodegeneration.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8272286</pmid><doi>10.1016/S0149-7634(05)80016-8</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-7634 |
| ispartof | Neuroscience and biobehavioral reviews, 1993, Vol.17 (3), p.347-357 |
| issn | 0149-7634 1873-7528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16789747 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging Animals Biological and medical sciences Carcinogenesis Development. Metamorphosis. Moult. Ageing Free Radical Scavengers Free radicals Fundamental and applied biological sciences. Psychology Humans Hydroxyl Radical - metabolism Indoleamines Kynuramines Melatonin - metabolism Melatonin - physiology Pineal gland Psychotogens Vertebrates: anatomy and physiology, studies on body, several organs or systems β-Carbolines |
| title | The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T18%3A46%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20significance%20of%20the%20metabolism%20of%20the%20neurohormone%20melatonin:%20Antioxidative%20protection%20and%20formation%20of%20bioactive%20substances&rft.jtitle=Neuroscience%20and%20biobehavioral%20reviews&rft.au=Hardeland,%20R.&rft.date=1993&rft.volume=17&rft.issue=3&rft.spage=347&rft.epage=357&rft.pages=347-357&rft.issn=0149-7634&rft.eissn=1873-7528&rft_id=info:doi/10.1016/S0149-7634(05)80016-8&rft_dat=%3Cproquest_cross%3E16789747%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16789747&rft_id=info:pmid/8272286&rft_els_id=S0149763405800168&rfr_iscdi=true |