Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer

The relationships between smoking and the expression of glutathione S-transferase (GST*) isozymes GSTM1–1, GSTM3–3, GSTP1–1 and GSTA1–1/2–2 (GSTA1/2), or between smoking and activities of epoxide hydrolase (EH) and aryl hydrocarbon hydroxylase (AHH) were investigated in lung samples from 27 patients...

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Veröffentlicht in:	Carcinogenesis (New York) 1995-04, Vol.16 (4), p.707-711
Hauptverfasser:	Nakajima, Tamie, Elovaara, Eivor, Anttila, Sisko, Hirvonen, Ari, Camus, Anne-Marie, Hayes, John D., Ketterer, Brian, Vainio, Harri
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences cancer epoxide hydrolase Epoxide Hydrolases - metabolism Female Gene Expression glutathione transferase Glutathione Transferase - biosynthesis Glutathione Transferase - genetics Glutathione Transferase - metabolism GSTM1 gene Humans Immunoblotting Isoenzymes - biosynthesis Isoenzymes - genetics Isoenzymes - metabolism lung Lung - enzymology Lung Neoplasms - enzymology Lung Neoplasms - etiology Lung Neoplasms - genetics Male man Medical sciences Microsomes - enzymology Pneumology polymorphism Polymorphism, Genetic Rabbits Risk Factors smoking Smoking - adverse effects Tumors of the respiratory system and mediastinum unspecific monooxygenase
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