cAMP-associated Inhibition of Phenobarbital-inducible Cytochrome P450 Gene Expression in Primary Rat Hepatocyte Cultures

The effects of elevated intracellular cyclic adenosine monophosphate (cAMP) in regulating phenobarbital (PB)-inducible gene expression in primary rat hepatocyte cultures were investigated. Cells were exposed to various concentrations (0.1-100 μM) of cAMP analogs and/or activators of intracellular cA...

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Veröffentlicht in:	The Journal of biological chemistry 1995-05, Vol.270 (21), p.12762-12773
Hauptverfasser:	Sidhu, Jaspreet S., Omiecinski, Curtis J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - biosynthesis Albumins - genetics Animals Aryl Hydrocarbon Hydroxylases Base Sequence Benzoflavones - pharmacology beta-Naphthoflavone Bucladesine - pharmacology Cells, Cultured Colforsin - pharmacology Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Cyclic AMP-Dependent Protein Kinases - agonists Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic GMP - pharmacology Cytochrome P-450 CYP3A Cytochrome P-450 Enzyme System - biosynthesis Dexamethasone - pharmacology Dichlororibofuranosylbenzimidazole - analogs & derivatives Dichlororibofuranosylbenzimidazole - pharmacology Dose-Response Relationship, Drug Enzyme Induction Gene Expression Regulation, Enzymologic Glucagon - pharmacology Liver - cytology Liver - drug effects Liver - metabolism Mixed Function Oxygenases - biosynthesis Molecular Sequence Data Phenobarbital - pharmacology Phosphodiesterase Inhibitors - pharmacology Rats Stereoisomerism Steroid Hydroxylases - biosynthesis Thionucleotides - pharmacology Transcriptional Activation
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