Inhalation Analgesia With Nitrous Oxide Versus Other Analgesic Techniques in Hysteroscopic Polypectomy: A Pilot Study
Abstract Study Objective To show the decrease in pain and better tolerance to inhalation analgesia with a 50% equimolar mixture of nitrogen protoxide and oxygen in hysteroscopic polypectomy compared with paracervical anesthesia and a control group. Design One hundred six patients scheduled for offic...
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| Veröffentlicht in: | Journal of minimally invasive gynecology 2015-05, Vol.22 (4), p.595-600 |
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| creator | del Valle Rubido, Cristina, MD Solano Calvo, Juan Antonio, MD, PhD Miguel, Antonio Rodríguez, MD Delgado Espeja, Juan José, MD González Hinojosa, Jerónimo, MD Zapico Goñi, Álvaro, MD, PhD |
| description | Abstract Study Objective To show the decrease in pain and better tolerance to inhalation analgesia with a 50% equimolar mixture of nitrogen protoxide and oxygen in hysteroscopic polypectomy compared with paracervical anesthesia and a control group. Design One hundred six patients scheduled for office hysteroscopy and polypectomy were divided into the following 3 groups: the control group, the nitrous oxide group, and the paracervical infiltration group. Patients were assigned sequentially (Canadian Task Force classification II-1). Setting The study took place in a hysteroscopy outpatient clinic under the supervision of a gynecologist and 2 nurses trained to cooperate in the trial. Patients One hundred six women from Area III of Madrid Community, Spain, who had been diagnosed with endometrial polyps at a gynecology office and were scheduled for office hysteroscopy and polypectomy agreed to participate in the study. Interventions Patients in group 1 (control group) received no treatment. Group 2 received inhaled nitrous oxide and group 3 paracervical infiltration with 1% lidocaine. Measurements and Main Results Pain was assessed using the visual analog scale (0–10). Pain perceived by patients was lower in the nitrous Oxide group (mean: 3.55 ± 0.60, median: 3) versus the control group (mean: 5.49 ± 1.88, median: 6, p |
| doi_str_mv | 10.1016/j.jmig.2015.01.005 |
| format | Article |
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Design One hundred six patients scheduled for office hysteroscopy and polypectomy were divided into the following 3 groups: the control group, the nitrous oxide group, and the paracervical infiltration group. Patients were assigned sequentially (Canadian Task Force classification II-1). Setting The study took place in a hysteroscopy outpatient clinic under the supervision of a gynecologist and 2 nurses trained to cooperate in the trial. Patients One hundred six women from Area III of Madrid Community, Spain, who had been diagnosed with endometrial polyps at a gynecology office and were scheduled for office hysteroscopy and polypectomy agreed to participate in the study. Interventions Patients in group 1 (control group) received no treatment. Group 2 received inhaled nitrous oxide and group 3 paracervical infiltration with 1% lidocaine. Measurements and Main Results Pain was assessed using the visual analog scale (0–10). Pain perceived by patients was lower in the nitrous Oxide group (mean: 3.55 ± 0.60, median: 3) versus the control group (mean: 5.49 ± 1.88, median: 6, p < .05) and the paracervical infiltration group (mean: 4.22 ± 1.73, median: 5). Tolerance to pain, assessed by the medical staff using qualitative variables, was bad for the control group, very good for the nitrous oxide group, and good for the paracervical infiltration group (p < .05). There were no complications in 82% of the patients in the nitrous oxide group, whereas in the paracervical infiltration group, there were complications in more than 50% of the patients. No severe complications occurred. Conclusion Nitrous oxide is a safe and effective analgesic technique for polipectomy office hysteroscopy compared with the paracervical infiltration and control groups.</description><identifier>ISSN: 1553-4650</identifier><identifier>EISSN: 1553-4669</identifier><identifier>DOI: 10.1016/j.jmig.2015.01.005</identifier><identifier>PMID: 25596171</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Administration, Inhalation ; Adult ; Analgesia ; Analgesics - administration & dosage ; Endometrial polyp ; Endometrium - surgery ; Female ; Humans ; Hysteroscopy ; Hysteroscopy - adverse effects ; Hysteroscopy - methods ; Lidocaine - administration & dosage ; Nitrous oxide ; Nitrous Oxide - administration & dosage ; Obstetrics and Gynecology ; Pain Measurement ; Pilot Projects ; Polypectomy ; Polyps - surgery ; Pregnancy ; Surgery ; Treatment Outcome</subject><ispartof>Journal of minimally invasive gynecology, 2015-05, Vol.22 (4), p.595-600</ispartof><rights>AAGL</rights><rights>2015 AAGL</rights><rights>Copyright © 2015 AAGL. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-2b69e5593280d5ddde53f04689cba46367063ef7572dd7f945a3a92b8ea40d863</citedby><cites>FETCH-LOGICAL-c411t-2b69e5593280d5ddde53f04689cba46367063ef7572dd7f945a3a92b8ea40d863</cites><orcidid>0000-0003-1091-8897</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1553465015000102$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25596171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>del Valle Rubido, Cristina, MD</creatorcontrib><creatorcontrib>Solano Calvo, Juan Antonio, MD, PhD</creatorcontrib><creatorcontrib>Miguel, Antonio Rodríguez, MD</creatorcontrib><creatorcontrib>Delgado Espeja, Juan José, MD</creatorcontrib><creatorcontrib>González Hinojosa, Jerónimo, MD</creatorcontrib><creatorcontrib>Zapico Goñi, Álvaro, MD, PhD</creatorcontrib><title>Inhalation Analgesia With Nitrous Oxide Versus Other Analgesic Techniques in Hysteroscopic Polypectomy: A Pilot Study</title><title>Journal of minimally invasive gynecology</title><addtitle>J Minim Invasive Gynecol</addtitle><description>Abstract Study Objective To show the decrease in pain and better tolerance to inhalation analgesia with a 50% equimolar mixture of nitrogen protoxide and oxygen in hysteroscopic polypectomy compared with paracervical anesthesia and a control group. Design One hundred six patients scheduled for office hysteroscopy and polypectomy were divided into the following 3 groups: the control group, the nitrous oxide group, and the paracervical infiltration group. Patients were assigned sequentially (Canadian Task Force classification II-1). Setting The study took place in a hysteroscopy outpatient clinic under the supervision of a gynecologist and 2 nurses trained to cooperate in the trial. Patients One hundred six women from Area III of Madrid Community, Spain, who had been diagnosed with endometrial polyps at a gynecology office and were scheduled for office hysteroscopy and polypectomy agreed to participate in the study. Interventions Patients in group 1 (control group) received no treatment. Group 2 received inhaled nitrous oxide and group 3 paracervical infiltration with 1% lidocaine. Measurements and Main Results Pain was assessed using the visual analog scale (0–10). Pain perceived by patients was lower in the nitrous Oxide group (mean: 3.55 ± 0.60, median: 3) versus the control group (mean: 5.49 ± 1.88, median: 6, p < .05) and the paracervical infiltration group (mean: 4.22 ± 1.73, median: 5). Tolerance to pain, assessed by the medical staff using qualitative variables, was bad for the control group, very good for the nitrous oxide group, and good for the paracervical infiltration group (p < .05). There were no complications in 82% of the patients in the nitrous oxide group, whereas in the paracervical infiltration group, there were complications in more than 50% of the patients. No severe complications occurred. Conclusion Nitrous oxide is a safe and effective analgesic technique for polipectomy office hysteroscopy compared with the paracervical infiltration and control groups.</description><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Analgesia</subject><subject>Analgesics - administration & dosage</subject><subject>Endometrial polyp</subject><subject>Endometrium - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Hysteroscopy</subject><subject>Hysteroscopy - adverse effects</subject><subject>Hysteroscopy - methods</subject><subject>Lidocaine - administration & dosage</subject><subject>Nitrous oxide</subject><subject>Nitrous Oxide - administration & dosage</subject><subject>Obstetrics and Gynecology</subject><subject>Pain Measurement</subject><subject>Pilot Projects</subject><subject>Polypectomy</subject><subject>Polyps - surgery</subject><subject>Pregnancy</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><issn>1553-4650</issn><issn>1553-4669</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc1u1DAYjBAVLYUX4IB85LLhcxw7CUJIqwpopYpWammPltf-0nVI4q3tIPL2ONqyBw492ZZnRvOTZe8o5BSo-Njl3WAf8gIoz4HmAPxFdkI5Z6tSiObl4c7hOHsdQgfAKgDxKjsuOG8ErehJNl2MW9WraN1I1qPqHzBYRe5t3JIfNno3BXL1xxokd-jD8ohb9AekJreot6N9nDAQO5LzOUT0Lmi3S3_Xrp93qKMb5k9kTa5t7yK5iZOZ32RHreoDvn06T7Of377enp2vLq--X5ytL1e6pDSuio1oMFllRQ2GG2OQsxZKUTd6o0rBRAWCYVvxqjCmapuSK6aaYlOjKsHUgp1mH_a6O-8Wj1EONmjsezViiiapqOqqrGvOErTYQ3XyHzy2cuftoPwsKcilbtnJpW651C2BylR3Ir1_0p82A5oD5V-_CfB5D8CU8rdFL4O2OGo01qdmpHH2ef0v_9F1b0erVf8LZwydm3xaIuWQoZAgb5bBl70pBwAKBfsLe0emqg</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>del Valle Rubido, Cristina, MD</creator><creator>Solano Calvo, Juan Antonio, MD, PhD</creator><creator>Miguel, Antonio Rodríguez, MD</creator><creator>Delgado Espeja, Juan José, MD</creator><creator>González Hinojosa, Jerónimo, MD</creator><creator>Zapico Goñi, Álvaro, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1091-8897</orcidid></search><sort><creationdate>20150501</creationdate><title>Inhalation Analgesia With Nitrous Oxide Versus Other Analgesic Techniques in Hysteroscopic Polypectomy: A Pilot Study</title><author>del Valle Rubido, Cristina, MD ; Solano Calvo, Juan Antonio, MD, PhD ; Miguel, Antonio Rodríguez, MD ; Delgado Espeja, Juan José, MD ; González Hinojosa, Jerónimo, MD ; Zapico Goñi, Álvaro, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-2b69e5593280d5ddde53f04689cba46367063ef7572dd7f945a3a92b8ea40d863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Administration, Inhalation</topic><topic>Adult</topic><topic>Analgesia</topic><topic>Analgesics - administration & dosage</topic><topic>Endometrial polyp</topic><topic>Endometrium - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Hysteroscopy</topic><topic>Hysteroscopy - adverse effects</topic><topic>Hysteroscopy - methods</topic><topic>Lidocaine - administration & dosage</topic><topic>Nitrous oxide</topic><topic>Nitrous Oxide - administration & dosage</topic><topic>Obstetrics and Gynecology</topic><topic>Pain Measurement</topic><topic>Pilot Projects</topic><topic>Polypectomy</topic><topic>Polyps - surgery</topic><topic>Pregnancy</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>del Valle Rubido, Cristina, MD</creatorcontrib><creatorcontrib>Solano Calvo, Juan Antonio, MD, PhD</creatorcontrib><creatorcontrib>Miguel, Antonio Rodríguez, MD</creatorcontrib><creatorcontrib>Delgado Espeja, Juan José, MD</creatorcontrib><creatorcontrib>González Hinojosa, Jerónimo, MD</creatorcontrib><creatorcontrib>Zapico Goñi, Álvaro, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of minimally invasive gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>del Valle Rubido, Cristina, MD</au><au>Solano Calvo, Juan Antonio, MD, PhD</au><au>Miguel, Antonio Rodríguez, MD</au><au>Delgado Espeja, Juan José, MD</au><au>González Hinojosa, Jerónimo, MD</au><au>Zapico Goñi, Álvaro, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhalation Analgesia With Nitrous Oxide Versus Other Analgesic Techniques in Hysteroscopic Polypectomy: A Pilot Study</atitle><jtitle>Journal of minimally invasive gynecology</jtitle><addtitle>J Minim Invasive Gynecol</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>22</volume><issue>4</issue><spage>595</spage><epage>600</epage><pages>595-600</pages><issn>1553-4650</issn><eissn>1553-4669</eissn><abstract>Abstract Study Objective To show the decrease in pain and better tolerance to inhalation analgesia with a 50% equimolar mixture of nitrogen protoxide and oxygen in hysteroscopic polypectomy compared with paracervical anesthesia and a control group. Design One hundred six patients scheduled for office hysteroscopy and polypectomy were divided into the following 3 groups: the control group, the nitrous oxide group, and the paracervical infiltration group. Patients were assigned sequentially (Canadian Task Force classification II-1). Setting The study took place in a hysteroscopy outpatient clinic under the supervision of a gynecologist and 2 nurses trained to cooperate in the trial. Patients One hundred six women from Area III of Madrid Community, Spain, who had been diagnosed with endometrial polyps at a gynecology office and were scheduled for office hysteroscopy and polypectomy agreed to participate in the study. Interventions Patients in group 1 (control group) received no treatment. Group 2 received inhaled nitrous oxide and group 3 paracervical infiltration with 1% lidocaine. Measurements and Main Results Pain was assessed using the visual analog scale (0–10). Pain perceived by patients was lower in the nitrous Oxide group (mean: 3.55 ± 0.60, median: 3) versus the control group (mean: 5.49 ± 1.88, median: 6, p < .05) and the paracervical infiltration group (mean: 4.22 ± 1.73, median: 5). Tolerance to pain, assessed by the medical staff using qualitative variables, was bad for the control group, very good for the nitrous oxide group, and good for the paracervical infiltration group (p < .05). There were no complications in 82% of the patients in the nitrous oxide group, whereas in the paracervical infiltration group, there were complications in more than 50% of the patients. No severe complications occurred. Conclusion Nitrous oxide is a safe and effective analgesic technique for polipectomy office hysteroscopy compared with the paracervical infiltration and control groups.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25596171</pmid><doi>10.1016/j.jmig.2015.01.005</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-1091-8897</orcidid></addata></record> |
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| subjects | Administration, Inhalation Adult Analgesia Analgesics - administration & dosage Endometrial polyp Endometrium - surgery Female Humans Hysteroscopy Hysteroscopy - adverse effects Hysteroscopy - methods Lidocaine - administration & dosage Nitrous oxide Nitrous Oxide - administration & dosage Obstetrics and Gynecology Pain Measurement Pilot Projects Polypectomy Polyps - surgery Pregnancy Surgery Treatment Outcome |
| title | Inhalation Analgesia With Nitrous Oxide Versus Other Analgesic Techniques in Hysteroscopic Polypectomy: A Pilot Study |
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