Comparison of the 2007 and 2013 ASCO/CAP evaluation systems for HER2 amplification in breast cancer
It has been proven that chromosome 17 centromere (CEP17) amplification causes misleading human epidermal growth factor receptor 2 (HER2) gene fluorescence in situ hybridization (FISH) results, precluding anti-HER2-based therapy in some patients with breast carcinoma. We used the 2013 American Societ...
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| Veröffentlicht in: | Pathology, research and practice research and practice, 2015-06, Vol.211 (6), p.421-425 |
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| creator | Pu, Xiaohong Shi, Jiong Li, Zhiwen Feng, Anning Ye, Qing |
| description | It has been proven that chromosome 17 centromere (CEP17) amplification causes misleading human epidermal growth factor receptor 2 (HER2) gene fluorescence in situ hybridization (FISH) results, precluding anti-HER2-based therapy in some patients with breast carcinoma. We used the 2013 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) scoring criteria to evaluate HER2 amplification status in 175 cases of breast carcinoma with chromosome 17 polysomy. We used immunohistochemistry (IHC) to determine the HER2 amplification status, and 2-color FISH to detect CEP17, and reviewed the results of initial evaluation using the 2007 ASCO/CAP criteria. Of the 175 cases, 17, 95, and 63 were IHC 0/1+, 2+, and 3+, respectively. Evaluation of IHC HER2 status according to the 2013 ASCO/CAP criteria identified significantly more HER2-positive cases compared to cases evaluated using the 2007 criteria (p |
| doi_str_mv | 10.1016/j.prp.2014.09.010 |
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We used the 2013 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) scoring criteria to evaluate HER2 amplification status in 175 cases of breast carcinoma with chromosome 17 polysomy. We used immunohistochemistry (IHC) to determine the HER2 amplification status, and 2-color FISH to detect CEP17, and reviewed the results of initial evaluation using the 2007 ASCO/CAP criteria. Of the 175 cases, 17, 95, and 63 were IHC 0/1+, 2+, and 3+, respectively. Evaluation of IHC HER2 status according to the 2013 ASCO/CAP criteria identified significantly more HER2-positive cases compared to cases evaluated using the 2007 criteria (p<0.05). When the FISH results were evaluated in parallel with the 2013 criteria, we found that 22 cases were not HER2-negative despite the presence of polysomy 17, which, according to the 2013 criteria, indicates HER2-positive status. Our findings indicate that in breast carcinoma, HER2 status in the presence of polysomy 17 may vary with the scoring criteria used. In turn, performing FISH and evaluating samples using the 2013 ASCO/CAP criteria means that more patients with breast cancer may be appropriate for targeted treatment with trastuzumab, potentially improving their outcome.</description><identifier>ISSN: 0344-0338</identifier><identifier>EISSN: 1618-0631</identifier><identifier>DOI: 10.1016/j.prp.2014.09.010</identifier><identifier>PMID: 25818873</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>2013 ASCO/CAP scoring criteria ; Adult ; Aged ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - diagnosis ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - pathology ; Chromosome 17 polysomy ; Chromosomes, Human, Pair 17 - genetics ; Female ; Gene Amplification - genetics ; HER2 ; Humans ; Immunohistochemistry - methods ; In Situ Hybridization, Fluorescence - methods ; Middle Aged ; Receptor, ErbB-2 - genetics</subject><ispartof>Pathology, research and practice, 2015-06, Vol.211 (6), p.421-425</ispartof><rights>2014 The Authors</rights><rights>Copyright © 2014 The Authors. Published by Elsevier GmbH.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-bec42d9407999b86141303fe66d9b8cb9b5c83422af50e8408a6c09cdefe12f43</citedby><cites>FETCH-LOGICAL-c536t-bec42d9407999b86141303fe66d9b8cb9b5c83422af50e8408a6c09cdefe12f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.prp.2014.09.010$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25818873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pu, Xiaohong</creatorcontrib><creatorcontrib>Shi, Jiong</creatorcontrib><creatorcontrib>Li, Zhiwen</creatorcontrib><creatorcontrib>Feng, Anning</creatorcontrib><creatorcontrib>Ye, Qing</creatorcontrib><title>Comparison of the 2007 and 2013 ASCO/CAP evaluation systems for HER2 amplification in breast cancer</title><title>Pathology, research and practice</title><addtitle>Pathol Res Pract</addtitle><description>It has been proven that chromosome 17 centromere (CEP17) amplification causes misleading human epidermal growth factor receptor 2 (HER2) gene fluorescence in situ hybridization (FISH) results, precluding anti-HER2-based therapy in some patients with breast carcinoma. We used the 2013 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) scoring criteria to evaluate HER2 amplification status in 175 cases of breast carcinoma with chromosome 17 polysomy. We used immunohistochemistry (IHC) to determine the HER2 amplification status, and 2-color FISH to detect CEP17, and reviewed the results of initial evaluation using the 2007 ASCO/CAP criteria. Of the 175 cases, 17, 95, and 63 were IHC 0/1+, 2+, and 3+, respectively. Evaluation of IHC HER2 status according to the 2013 ASCO/CAP criteria identified significantly more HER2-positive cases compared to cases evaluated using the 2007 criteria (p<0.05). When the FISH results were evaluated in parallel with the 2013 criteria, we found that 22 cases were not HER2-negative despite the presence of polysomy 17, which, according to the 2013 criteria, indicates HER2-positive status. Our findings indicate that in breast carcinoma, HER2 status in the presence of polysomy 17 may vary with the scoring criteria used. In turn, performing FISH and evaluating samples using the 2013 ASCO/CAP criteria means that more patients with breast cancer may be appropriate for targeted treatment with trastuzumab, potentially improving their outcome.</description><subject>2013 ASCO/CAP scoring criteria</subject><subject>Adult</subject><subject>Aged</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - diagnosis</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Chromosome 17 polysomy</subject><subject>Chromosomes, Human, Pair 17 - genetics</subject><subject>Female</subject><subject>Gene Amplification - genetics</subject><subject>HER2</subject><subject>Humans</subject><subject>Immunohistochemistry - methods</subject><subject>In Situ Hybridization, Fluorescence - methods</subject><subject>Middle Aged</subject><subject>Receptor, ErbB-2 - genetics</subject><issn>0344-0338</issn><issn>1618-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpabZpf0AuRcde7MxYWlkmp8XkoxBIaZOzkOUR0eKvSt5A_n0UNs2xF41m9MwLehg7QygRUJ3vyyUuZQUoS2hKQPjANqhQF6AEfmQbEFIWIIQ-YV9S2gNADRI_s5Nqq1HrWmyYa-dxsTGkeeKz5-sj8Spj3E59vqDguz_t3Xm7-8XpyQ4Hu4YMpue00pi4nyO_ufxdcTsuQ_DBHZ_DxLtINq3c2clR_Mo-eTsk-vZWT9nD1eV9e1Pc3l3_bHe3hdsKtRYdOVn1jYS6aZpOK5QoQHhSqs-t65pu67SQVWX9FkhL0FY5aFxPnrDyUpyyH8fcJc5_D5RWM4bkaBjsRPMhGVS1rqXOR0bxiLo4pxTJmyWG0cZng2Be3Zp9nizm1a2BxmS3eef7W_yhG6l_3_gnMwMXR4DyJ58CRZNcoGygD5Hcavo5_Cf-BdeAh38</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Pu, Xiaohong</creator><creator>Shi, Jiong</creator><creator>Li, Zhiwen</creator><creator>Feng, Anning</creator><creator>Ye, Qing</creator><general>Elsevier GmbH</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150601</creationdate><title>Comparison of the 2007 and 2013 ASCO/CAP evaluation systems for HER2 amplification in breast cancer</title><author>Pu, Xiaohong ; Shi, Jiong ; Li, Zhiwen ; Feng, Anning ; Ye, Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-bec42d9407999b86141303fe66d9b8cb9b5c83422af50e8408a6c09cdefe12f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>2013 ASCO/CAP scoring criteria</topic><topic>Adult</topic><topic>Aged</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - diagnosis</topic><topic>Carcinoma, Ductal, Breast - genetics</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Chromosome 17 polysomy</topic><topic>Chromosomes, Human, Pair 17 - genetics</topic><topic>Female</topic><topic>Gene Amplification - genetics</topic><topic>HER2</topic><topic>Humans</topic><topic>Immunohistochemistry - methods</topic><topic>In Situ Hybridization, Fluorescence - methods</topic><topic>Middle Aged</topic><topic>Receptor, ErbB-2 - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pu, Xiaohong</creatorcontrib><creatorcontrib>Shi, Jiong</creatorcontrib><creatorcontrib>Li, Zhiwen</creatorcontrib><creatorcontrib>Feng, Anning</creatorcontrib><creatorcontrib>Ye, Qing</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology, research and practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pu, Xiaohong</au><au>Shi, Jiong</au><au>Li, Zhiwen</au><au>Feng, Anning</au><au>Ye, Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the 2007 and 2013 ASCO/CAP evaluation systems for HER2 amplification in breast cancer</atitle><jtitle>Pathology, research and practice</jtitle><addtitle>Pathol Res Pract</addtitle><date>2015-06-01</date><risdate>2015</risdate><volume>211</volume><issue>6</issue><spage>421</spage><epage>425</epage><pages>421-425</pages><issn>0344-0338</issn><eissn>1618-0631</eissn><abstract>It has been proven that chromosome 17 centromere (CEP17) amplification causes misleading human epidermal growth factor receptor 2 (HER2) gene fluorescence in situ hybridization (FISH) results, precluding anti-HER2-based therapy in some patients with breast carcinoma. We used the 2013 American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) scoring criteria to evaluate HER2 amplification status in 175 cases of breast carcinoma with chromosome 17 polysomy. We used immunohistochemistry (IHC) to determine the HER2 amplification status, and 2-color FISH to detect CEP17, and reviewed the results of initial evaluation using the 2007 ASCO/CAP criteria. Of the 175 cases, 17, 95, and 63 were IHC 0/1+, 2+, and 3+, respectively. Evaluation of IHC HER2 status according to the 2013 ASCO/CAP criteria identified significantly more HER2-positive cases compared to cases evaluated using the 2007 criteria (p<0.05). When the FISH results were evaluated in parallel with the 2013 criteria, we found that 22 cases were not HER2-negative despite the presence of polysomy 17, which, according to the 2013 criteria, indicates HER2-positive status. Our findings indicate that in breast carcinoma, HER2 status in the presence of polysomy 17 may vary with the scoring criteria used. In turn, performing FISH and evaluating samples using the 2013 ASCO/CAP criteria means that more patients with breast cancer may be appropriate for targeted treatment with trastuzumab, potentially improving their outcome.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>25818873</pmid><doi>10.1016/j.prp.2014.09.010</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 2013 ASCO/CAP scoring criteria Adult Aged Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - diagnosis Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Chromosome 17 polysomy Chromosomes, Human, Pair 17 - genetics Female Gene Amplification - genetics HER2 Humans Immunohistochemistry - methods In Situ Hybridization, Fluorescence - methods Middle Aged Receptor, ErbB-2 - genetics |
| title | Comparison of the 2007 and 2013 ASCO/CAP evaluation systems for HER2 amplification in breast cancer |
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