Induction of oxidative DNA damage and early lesions in rat gastro-intestinal epithelium in relation to prostaglandin H synthase-mediated metabolism of butylated hydroxyanisole

The effect of metabolic activation of the food additive 3- tert-butyl-4-hydroxyanisole (BHA) by prostaglandin H synthase on the gastro-intestinal cell proliferation was determined by studies of the nature and the time dependency of early lesions in the forestomach, glandular stomach and colon/rectum...

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Veröffentlicht in:	Food and chemical toxicology 1995, Vol.33 (2), p.99-109
Hauptverfasser:	Schilderman, P.A.E.L., ten Vaarwerk, F.J., Lutgerink, J.T., Van Der Wurff, A., ten Hoor, F., Kleinjans, J.C.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspirin - pharmacology Biological and medical sciences Biotransformation - drug effects butylated hydroxyanisole Butylated Hydroxyanisole - metabolism Butylated Hydroxyanisole - toxicity Cell Division - drug effects Colon - drug effects Colon - enzymology Colon - pathology Cyclooxygenase Inhibitors - pharmacology Deoxyguanosine - analogs & derivatives Deoxyguanosine - biosynthesis digestive system Digestive System - drug effects Digestive System - enzymology Digestive System - pathology DNA DNA Damage - drug effects DNA Damage - physiology Dose-Response Relationship, Drug Drug Interactions Epithelium - drug effects Epithelium - enzymology Epithelium - pathology food additives Food Additives - metabolism Food Additives - toxicity Food toxicology Hyperplasia Inflammation - chemically induced lesions Liver - drug effects Liver - enzymology Liver - pathology Male Medical sciences metabolism Oxidation-Reduction Prostaglandin-Endoperoxide Synthases - metabolism prostaglandins Rats Rats, Wistar Reactive Oxygen Species Rectum - drug effects Rectum - enzymology Rectum - pathology Stomach - drug effects Stomach - enzymology Stomach - pathology Toxicology
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