8-Aminoguanine: A base modification produced in rat liver nucleic acids by the hepatocarcinogen 2-nitropropane

2-Nitropropane (2-NP), an important industrial chemical and a hepatocarcinogen in rats, had previously been found to produce several modifications of nucleosides in rat liver RNA and DNA that are discernible using HPLC with electrochemical detection. While one of these modifications has been identif...

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Veröffentlicht in:	Chemical research in toxicology 1993-05, Vol.6 (3), p.269-276
Hauptverfasser:	Sodum, Rama S, Nie, Guo, Fiala, Emerich S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Composition - drug effects Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Carcinogens - toxicity Chemical agents Deoxyguanosine - analogs & derivatives Deoxyguanosine - chemistry Deoxyguanosine - metabolism Guanine - analogs & derivatives Guanine - chemistry Guanine - metabolism Guanosine - analogs & derivatives Guanosine - chemistry Guanosine - metabolism Liver - drug effects Liver - metabolism Male Medical sciences Nitroparaffins - toxicity Propane - analogs & derivatives Propane - toxicity Purine-Nucleoside Phosphorylase - antagonists & inhibitors Rats Rats, Inbred F344 Tumors
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