Effect of the Peroxisome Proliferator Perfluoro-n-decanoic Acid on Glucose Transport in the Isolated Perfused Rat Liver

The perfluorinated carboxylic acid, perfluoro-n-decanoic acid (PFDA), is a known peroxisome proliferator which displays toxicity in rodents. Using a paired-tracer first-pass extraction technique, the effect of PFDA on hepatic glucose transport was determined in the isolated perfused rat liver. In br...

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Veröffentlicht in:	Chemical research in toxicology 1995-01, Vol.8 (1), p.77-81
Hauptverfasser:	Goecke-Flora, Carol M, Wyman, John F, Jarnot, Bruce M, Reo, Nicholas V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport - drug effects Cell Division - drug effects Decanoic Acids - toxicity Fluorocarbons - toxicity Glucose - metabolism L-Lactate Dehydrogenase - secretion Liver - drug effects Liver - metabolism Male Membrane Fluidity - drug effects Microbodies - drug effects Perfusion Rats Rats, Inbred F344
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