Novel Ca super(2+)-ATPase inhibitors from the dried root tubers of Polygonum multiflorum

Novel Ca super(2+)-ATPase inhibitors from the dried root tubers of Polygonum multiflorum

The MeOH extract of the dried root tubers of Polygonum multiflorum yielded three bioactive compounds with an inhibitory activity on calmodulin-depleted erythrocyte calcium-dependent ATPase. These compounds were identified as E-2,3,5,4'-tetrahydroxystilbene 2-O- beta -D-glucopyranoside [2] (IC s...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 1994-01, Vol.57 (12), p.1682-1687
Hauptverfasser: Grech, J N, Li, Qian, Roufogalis, B D, Duke, C C
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Polygonum multiflorum
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container_issue 12
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container_title Journal of natural products (Washington, D.C.)
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creator Grech, J N
Li, Qian
Roufogalis, B D
Duke, C C
description The MeOH extract of the dried root tubers of Polygonum multiflorum yielded three bioactive compounds with an inhibitory activity on calmodulin-depleted erythrocyte calcium-dependent ATPase. These compounds were identified as E-2,3,5,4'-tetrahydroxystilbene 2-O- beta -D-glucopyranoside [2] (IC sub(50) = 240 mu M) and cis- and trans-E-3-butylidene-4,5,6,7-tetrahydro-6,7 dihydroxy-1(3H)-isobenzofuranone [3 and 4] (IC sub(50) = 160 and 260 mu M, respectively). E-2,4,6,4'-Tetrahydroxystilbene 2-O- beta -D-glucopyranoside [1] was also isolated but was found to have no inhibitory effect on the enzyme.
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title Novel Ca super(2+)-ATPase inhibitors from the dried root tubers of Polygonum multiflorum
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