Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins

The human proto-oncogene PBX1 codes for a homolog of Drosophila extradenticle, a divergent homeo domain protein that modulates the developmental and DNA-binding specificity of select HOM proteins. We demonstrate that wild-type Pbx proteins and chimeric E2a-Pbx1 oncoproteins cooperatively bind a cons...

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Veröffentlicht in:	Genes & development 1995-03, Vol.9 (6), p.663-674
Hauptverfasser:	Chang, C P, Shen, W F, Rozenfeld, S, Lawrence, H J, Largman, C, Cleary, M L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological Evolution Conserved Sequence DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drosophila - genetics Homeobox A10 Proteins Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Molecular Sequence Data Nucleic Acid Hybridization Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Pre-B-Cell Leukemia Transcription Factor 1 Precipitin Tests Protein Binding Proto-Oncogene Mas Proto-Oncogene Proteins - metabolism Recombinant Fusion Proteins - metabolism Structure-Activity Relationship Transcription Factors - genetics Transcription Factors - metabolism
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