Cross-desensitization of receptors for peptide chemoattractants. Characterization of a new form of leukocyte regulation

The formylpeptide (fMLP) and C5a chemoattractants were previously shown to cross-desensitize each other's ability to mobilize Ca2+ in leukocytes but not to affect nonchemoattractant Ca(2+)-mobilizing receptors, and vice versa. Our data show that all receptors studied underwent homologous desens...

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Veröffentlicht in:	The Journal of immunology (1950) 1994-10, Vol.153 (7), p.3267-3275
Hauptverfasser:	Tomhave, ED, Richardson, RM, Didsbury, JR, Menard, L, Snyderman, R, Ali, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Alkaloids - pharmacology Calcium - metabolism Cell Membrane - enzymology Chemotaxis, Leukocyte Cytochalasin B - pharmacology Down-Regulation - drug effects Enzyme Activation GTP Phosphohydrolases - metabolism GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - metabolism Humans In Vitro Techniques Neutrophils - metabolism Phospholipase D - metabolism Protein Kinase C - physiology Receptor, Anaphylatoxin C5a Receptors, Complement - metabolism Receptors, Formyl Peptide Receptors, Immunologic - metabolism Receptors, Peptide - metabolism Staurosporine Tetradecanoylphorbol Acetate - pharmacology
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