Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans
Thermoresponsive degalactosylated xyloglucans have been already proposed as in situ gelling scaffolds for tissue engineering, due to their reversible macroscopic thermal gelation at body temperature and biodegradability. The highly branched, hydroxyl group-rich molecular structure renders xyloglucan...
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| Veröffentlicht in: | Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2014-01, Vol.94, p.245-248 |
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| container_title | Radiation physics and chemistry (Oxford, England : 1993) |
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| creator | Todaro, S. Sabatino, M.A. Walo, M. Mangione, M.R. Bulone, D. Dispenza, C. |
| description | Thermoresponsive degalactosylated xyloglucans have been already proposed as in situ gelling scaffolds for tissue engineering, due to their reversible macroscopic thermal gelation at body temperature and biodegradability. The highly branched, hydroxyl group-rich molecular structure renders xyloglucans interesting raw materials also in the form of micro/nanoparticles for application as nanoscalar drug delivery devices in cosmetic and pharmaceutical formulations. Owing to their natural source, xyloglucans show high average molecular weight, broad molecular weight distribution and poor water solubility, as large and compact aggregates usually form via inter-molecular hydrogen bonding. 60Co γ-irradiation has been here applied to reduce the molecular weight. The aqueous solutions of irradiated xyloglucan were characterized by dynamic light scattering measurements and gel filtration chromatography. The aggregation kinetics at 37°C were studied by dynamic light scattering measurements to confirm the temperature-responsive behavior of this polymer even when dispersed in water at low concentration after γ-irradiation. Irradiation dose–molecular properties relationship has been sought.
•Influence of γ-irradiation on a partially degalactosylated xyloglucan is investigated.•Molecular weight reduction is observed in the investigated dose range.•Modification of the temperature-induced mesoscopic gelation kinetics is evidenced. |
| doi_str_mv | 10.1016/j.radphyschem.2013.05.055 |
| format | Article |
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•Influence of γ-irradiation on a partially degalactosylated xyloglucan is investigated.•Molecular weight reduction is observed in the investigated dose range.•Modification of the temperature-induced mesoscopic gelation kinetics is evidenced.</description><identifier>ISSN: 0969-806X</identifier><identifier>EISSN: 1879-0895</identifier><identifier>DOI: 10.1016/j.radphyschem.2013.05.055</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>60Co γ-irradiation ; Cosmetics ; Drug delivery systems ; Dynamic light scattering ; Dynamics ; Gel filtration chromatography ; Gelation ; Irradiation ; Light scattering ; Molecular weight ; Nanostructure ; Temperature responsive polymers ; Xyloglucan</subject><ispartof>Radiation physics and chemistry (Oxford, England : 1993), 2014-01, Vol.94, p.245-248</ispartof><rights>2013 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-fbf5a7f1460c42734b5955418917f58b17f33ad5f0156e5d26cc221930eb0d313</citedby><cites>FETCH-LOGICAL-c420t-fbf5a7f1460c42734b5955418917f58b17f33ad5f0156e5d26cc221930eb0d313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0969806X13003678$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Todaro, S.</creatorcontrib><creatorcontrib>Sabatino, M.A.</creatorcontrib><creatorcontrib>Walo, M.</creatorcontrib><creatorcontrib>Mangione, M.R.</creatorcontrib><creatorcontrib>Bulone, D.</creatorcontrib><creatorcontrib>Dispenza, C.</creatorcontrib><title>Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans</title><title>Radiation physics and chemistry (Oxford, England : 1993)</title><description>Thermoresponsive degalactosylated xyloglucans have been already proposed as in situ gelling scaffolds for tissue engineering, due to their reversible macroscopic thermal gelation at body temperature and biodegradability. The highly branched, hydroxyl group-rich molecular structure renders xyloglucans interesting raw materials also in the form of micro/nanoparticles for application as nanoscalar drug delivery devices in cosmetic and pharmaceutical formulations. Owing to their natural source, xyloglucans show high average molecular weight, broad molecular weight distribution and poor water solubility, as large and compact aggregates usually form via inter-molecular hydrogen bonding. 60Co γ-irradiation has been here applied to reduce the molecular weight. The aqueous solutions of irradiated xyloglucan were characterized by dynamic light scattering measurements and gel filtration chromatography. The aggregation kinetics at 37°C were studied by dynamic light scattering measurements to confirm the temperature-responsive behavior of this polymer even when dispersed in water at low concentration after γ-irradiation. Irradiation dose–molecular properties relationship has been sought.
•Influence of γ-irradiation on a partially degalactosylated xyloglucan is investigated.•Molecular weight reduction is observed in the investigated dose range.•Modification of the temperature-induced mesoscopic gelation kinetics is evidenced.</description><subject>60Co γ-irradiation</subject><subject>Cosmetics</subject><subject>Drug delivery systems</subject><subject>Dynamic light scattering</subject><subject>Dynamics</subject><subject>Gel filtration chromatography</subject><subject>Gelation</subject><subject>Irradiation</subject><subject>Light scattering</subject><subject>Molecular weight</subject><subject>Nanostructure</subject><subject>Temperature responsive polymers</subject><subject>Xyloglucan</subject><issn>0969-806X</issn><issn>1879-0895</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNkU9r3DAQxUVpoNs038G99eLNyPL4z7EsbRMI9NJCb0IrjbxaZGsr2aX-9pXZHHJr4DEDw28ewzzGPnLYc-DN_Xkflbmc1qRPNO4r4GIPmIVv2I53bV9C1-NbtoO-6csOml_v2PuUzgDQdih2bHicrF9o0lQEWwxqHFXpYvZ0anZhKrLmE8VReb-WbjKLJlOMlELS4eJ0MZB_Bm1haFBe6TmkNQ8z93f1YfCLVlP6wG6s8onunvst-_n1y4_DQ_n0_dvj4fNTqesK5tIeLarW8rqBPGhFfcQeseZdz1uL3TFXIZRBCxwbQlM1WlcV7wXQEYzg4pZ9uvpeYvi9UJrl6JIm79VEYUmSN2237db4fxSr_DUE0b4ChaYGAbih_RXVMaQUycpLdKOKq-Qgt8jkWb6ITG6RScCs7aLDdZfyh_44ijJpt2VjXCQ9SxPcK1z-AZkupsI</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Todaro, S.</creator><creator>Sabatino, M.A.</creator><creator>Walo, M.</creator><creator>Mangione, M.R.</creator><creator>Bulone, D.</creator><creator>Dispenza, C.</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>201401</creationdate><title>Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans</title><author>Todaro, S. ; Sabatino, M.A. ; Walo, M. ; Mangione, M.R. ; Bulone, D. ; Dispenza, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-fbf5a7f1460c42734b5955418917f58b17f33ad5f0156e5d26cc221930eb0d313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>60Co γ-irradiation</topic><topic>Cosmetics</topic><topic>Drug delivery systems</topic><topic>Dynamic light scattering</topic><topic>Dynamics</topic><topic>Gel filtration chromatography</topic><topic>Gelation</topic><topic>Irradiation</topic><topic>Light scattering</topic><topic>Molecular weight</topic><topic>Nanostructure</topic><topic>Temperature responsive polymers</topic><topic>Xyloglucan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Todaro, S.</creatorcontrib><creatorcontrib>Sabatino, M.A.</creatorcontrib><creatorcontrib>Walo, M.</creatorcontrib><creatorcontrib>Mangione, M.R.</creatorcontrib><creatorcontrib>Bulone, D.</creatorcontrib><creatorcontrib>Dispenza, C.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Radiation physics and chemistry (Oxford, England : 1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Todaro, S.</au><au>Sabatino, M.A.</au><au>Walo, M.</au><au>Mangione, M.R.</au><au>Bulone, D.</au><au>Dispenza, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans</atitle><jtitle>Radiation physics and chemistry (Oxford, England : 1993)</jtitle><date>2014-01</date><risdate>2014</risdate><volume>94</volume><spage>245</spage><epage>248</epage><pages>245-248</pages><issn>0969-806X</issn><eissn>1879-0895</eissn><abstract>Thermoresponsive degalactosylated xyloglucans have been already proposed as in situ gelling scaffolds for tissue engineering, due to their reversible macroscopic thermal gelation at body temperature and biodegradability. The highly branched, hydroxyl group-rich molecular structure renders xyloglucans interesting raw materials also in the form of micro/nanoparticles for application as nanoscalar drug delivery devices in cosmetic and pharmaceutical formulations. Owing to their natural source, xyloglucans show high average molecular weight, broad molecular weight distribution and poor water solubility, as large and compact aggregates usually form via inter-molecular hydrogen bonding. 60Co γ-irradiation has been here applied to reduce the molecular weight. The aqueous solutions of irradiated xyloglucan were characterized by dynamic light scattering measurements and gel filtration chromatography. The aggregation kinetics at 37°C were studied by dynamic light scattering measurements to confirm the temperature-responsive behavior of this polymer even when dispersed in water at low concentration after γ-irradiation. Irradiation dose–molecular properties relationship has been sought.
•Influence of γ-irradiation on a partially degalactosylated xyloglucan is investigated.•Molecular weight reduction is observed in the investigated dose range.•Modification of the temperature-induced mesoscopic gelation kinetics is evidenced.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.radphyschem.2013.05.055</doi><tpages>4</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | 60Co γ-irradiation Cosmetics Drug delivery systems Dynamic light scattering Dynamics Gel filtration chromatography Gelation Irradiation Light scattering Molecular weight Nanostructure Temperature responsive polymers Xyloglucan |
| title | Influence of gamma-irradiation on thermally-induced mesoscopic gelation of degalactosylated xyloglucans |
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