Application of quantitative Raman spectroscopy for the monitoring of polymorphic transformation in crystallization processes using a good calibration practice procedure

•Raman spectroscopy used for quantitative monitoring of polymorphic crystallization.•Effects of multiple parameters on Raman spectra were studied.•Calibration models were developed for dry solid mixtures and slurries of polymorphs.•A good calibration practice (GCP) procedure was proposed.•Raman cali...

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Veröffentlicht in:	Chemical engineering research & design 2014-04, Vol.92 (4), p.594-611
Hauptverfasser:	Simone, E., Saleemi, A.N., Nagy, Z.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Calibration Crystallization Density Liquids Monitoring Monitors OABA Polymorphism Process analytical technologies Raman spectroscopy Transformations
Online-Zugang:	Volltext
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