Adult exposure to bisphenol A (BPA) in Wistar rats reduces sperm quality with disruption of the hypothalamic–pituitary–testicular axis

Abstract Reproductive physiology involves complex biological processes that can be disrupted by exposure to environmental contaminants. The effects of bisphenol A (BPA) on spermatogenesis and sperm quality is still unclear. The objective of this study was to investigate the reproductive toxicity of...

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Veröffentlicht in:	Toxicology (Amsterdam) 2015-03, Vol.329, p.1-9
Hauptverfasser:	Wisniewski, Patricia, Romano, Renata M, Kizys, Marina M.L, Oliveira, Kelen C, Kasamatsu, Teresa, Giannocco, Gisele, Chiamolera, Maria I, Dias-da-Silva, Magnus R, Romano, Marco A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Benzhydryl Compounds - toxicity Bisphenol A Dose-Response Relationship, Drug Emergency Epididymis - drug effects Epididymis - metabolism Estradiol - blood Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Exposure Follicle Stimulating Hormone - blood Gene expression Genes Gonadotropins Hormones Hypothalamo-Hypophyseal System - drug effects Luteinizing Hormone - blood Male Mitochondria - drug effects Mitochondria - metabolism Phenols - toxicity Rats Rats, Wistar Receptors Receptors, Androgen - genetics Receptors, Androgen - metabolism Receptors, LHRH - genetics Receptors, LHRH - metabolism Reproduction - drug effects Serums Sperm function Sperm production Spermatogenesis - drug effects Spermatozoa Spermatozoa - drug effects Spermatozoa - metabolism Testis - drug effects Testis - metabolism Testosterone Testosterone - blood
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