Environmentally relevant concentrations of galaxolide (HHCB) and tonalide (AHTN) induced oxidative and genetic damage in Dreissena polymorpha
•Galaxolide (HHCB) and tonalide (AHTN) are emerging aquatic pollutans.•HHCB and AHTN hazard to non-target aquatic organisms is largely unknown.•We measured HHCB- and AHTN-induced oxidative and genetic damage to the zebra mussel.•Environmental concentrations of both musks caused oxidative damage.•HHC...
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| Veröffentlicht in: | Journal of hazardous materials 2015-03, Vol.285, p.1-10 |
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| creator | Parolini, Marco Magni, Stefano Traversi, Irene Villa, Sara Finizio, Antonio Binelli, Andrea |
| description | •Galaxolide (HHCB) and tonalide (AHTN) are emerging aquatic pollutans.•HHCB and AHTN hazard to non-target aquatic organisms is largely unknown.•We measured HHCB- and AHTN-induced oxidative and genetic damage to the zebra mussel.•Environmental concentrations of both musks caused oxidative damage.•HHCB and AHTN induced DNA fragmentation but no fixed genetic damage.
Synthetic musk compounds (SMCs) are extensively used as fragrances in several personal care products and have been recognized as emerging aquatic pollutants. Among SMCs, galaxolide (HHCB) and tonalide (AHTN) are extensively used and have been measured in aquatic ecosystems worldwide. However, their potential risk to organisms remains largely unknown. The aim of this study was to investigate whether 21-day exposures to HHCB and AHTN concentrations frequently measured in aquatic ecosystems can induce oxidative and genetic damage in Dreissena polymorpha. The lipid peroxidation (LPO) and protein carbonyl content (PCC) were measured as oxidative stress indexes, while the DNA precipitation assay and the micronucleus test (MN test) were applied to investigate genetic injuries. HHCB induced significant increases in LPO and PCC levels, while AHTN enhanced only protein carbonylation. Moreover, significant increases in DNA strand breaks were caused by exposure to the highest concentrations of HHCB and AHTN tested in the present study, but no fixed genetic damage was observed. |
| doi_str_mv | 10.1016/j.jhazmat.2014.11.037 |
| format | Article |
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Synthetic musk compounds (SMCs) are extensively used as fragrances in several personal care products and have been recognized as emerging aquatic pollutants. Among SMCs, galaxolide (HHCB) and tonalide (AHTN) are extensively used and have been measured in aquatic ecosystems worldwide. However, their potential risk to organisms remains largely unknown. The aim of this study was to investigate whether 21-day exposures to HHCB and AHTN concentrations frequently measured in aquatic ecosystems can induce oxidative and genetic damage in Dreissena polymorpha. The lipid peroxidation (LPO) and protein carbonyl content (PCC) were measured as oxidative stress indexes, while the DNA precipitation assay and the micronucleus test (MN test) were applied to investigate genetic injuries. HHCB induced significant increases in LPO and PCC levels, while AHTN enhanced only protein carbonylation. Moreover, significant increases in DNA strand breaks were caused by exposure to the highest concentrations of HHCB and AHTN tested in the present study, but no fixed genetic damage was observed.</description><identifier>ISSN: 0304-3894</identifier><identifier>EISSN: 1873-3336</identifier><identifier>DOI: 10.1016/j.jhazmat.2014.11.037</identifier><identifier>PMID: 25462865</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Benzopyrans - analysis ; Benzopyrans - pharmacology ; Benzopyrans - toxicity ; Carbonyls ; Damage ; Deoxyribonucleic acid ; DNA Damage ; Dreissena - drug effects ; Dreissena - metabolism ; Dreissena polymorpha ; Ecosystems ; Exposure ; Galaxolide (HHCB) ; Genetics ; Lipid Peroxidation - drug effects ; Musk ; Oxidative and genetic damage ; Oxidative Stress - drug effects ; Perfume - analysis ; Perfume - pharmacology ; Perfume - toxicity ; Protein Carbonylation ; Proteins ; Stress concentration ; Tetrahydronaphthalenes - analysis ; Tetrahydronaphthalenes - pharmacology ; Tetrahydronaphthalenes - toxicity ; The exposure to environmental concentrations of galaxolide (HHCB) and tonalide (AHTN) induced significant oxidative and genetic damage to the zebra mussel ; Thiobarbituric Acid Reactive Substances - metabolism ; Tonalide (AHTN) ; Water Pollutants, Chemical - analysis ; Water Pollutants, Chemical - pharmacology ; Water Pollutants, Chemical - toxicity</subject><ispartof>Journal of hazardous materials, 2015-03, Vol.285, p.1-10</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-d160b329b8258d40ca830390c048928922087f7e2b299b6553f84968502ba5933</citedby><cites>FETCH-LOGICAL-c538t-d160b329b8258d40ca830390c048928922087f7e2b299b6553f84968502ba5933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304389414009443$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25462865$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parolini, Marco</creatorcontrib><creatorcontrib>Magni, Stefano</creatorcontrib><creatorcontrib>Traversi, Irene</creatorcontrib><creatorcontrib>Villa, Sara</creatorcontrib><creatorcontrib>Finizio, Antonio</creatorcontrib><creatorcontrib>Binelli, Andrea</creatorcontrib><title>Environmentally relevant concentrations of galaxolide (HHCB) and tonalide (AHTN) induced oxidative and genetic damage in Dreissena polymorpha</title><title>Journal of hazardous materials</title><addtitle>J Hazard Mater</addtitle><description>•Galaxolide (HHCB) and tonalide (AHTN) are emerging aquatic pollutans.•HHCB and AHTN hazard to non-target aquatic organisms is largely unknown.•We measured HHCB- and AHTN-induced oxidative and genetic damage to the zebra mussel.•Environmental concentrations of both musks caused oxidative damage.•HHCB and AHTN induced DNA fragmentation but no fixed genetic damage.
Synthetic musk compounds (SMCs) are extensively used as fragrances in several personal care products and have been recognized as emerging aquatic pollutants. Among SMCs, galaxolide (HHCB) and tonalide (AHTN) are extensively used and have been measured in aquatic ecosystems worldwide. However, their potential risk to organisms remains largely unknown. The aim of this study was to investigate whether 21-day exposures to HHCB and AHTN concentrations frequently measured in aquatic ecosystems can induce oxidative and genetic damage in Dreissena polymorpha. The lipid peroxidation (LPO) and protein carbonyl content (PCC) were measured as oxidative stress indexes, while the DNA precipitation assay and the micronucleus test (MN test) were applied to investigate genetic injuries. HHCB induced significant increases in LPO and PCC levels, while AHTN enhanced only protein carbonylation. Moreover, significant increases in DNA strand breaks were caused by exposure to the highest concentrations of HHCB and AHTN tested in the present study, but no fixed genetic damage was observed.</description><subject>Animals</subject><subject>Benzopyrans - analysis</subject><subject>Benzopyrans - pharmacology</subject><subject>Benzopyrans - toxicity</subject><subject>Carbonyls</subject><subject>Damage</subject><subject>Deoxyribonucleic acid</subject><subject>DNA Damage</subject><subject>Dreissena - drug effects</subject><subject>Dreissena - metabolism</subject><subject>Dreissena polymorpha</subject><subject>Ecosystems</subject><subject>Exposure</subject><subject>Galaxolide (HHCB)</subject><subject>Genetics</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Musk</subject><subject>Oxidative and genetic damage</subject><subject>Oxidative Stress - drug effects</subject><subject>Perfume - analysis</subject><subject>Perfume - pharmacology</subject><subject>Perfume - toxicity</subject><subject>Protein Carbonylation</subject><subject>Proteins</subject><subject>Stress concentration</subject><subject>Tetrahydronaphthalenes - analysis</subject><subject>Tetrahydronaphthalenes - pharmacology</subject><subject>Tetrahydronaphthalenes - toxicity</subject><subject>The exposure to environmental concentrations of galaxolide (HHCB) and tonalide (AHTN) induced significant oxidative and genetic damage to the zebra mussel</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Tonalide (AHTN)</subject><subject>Water Pollutants, Chemical - analysis</subject><subject>Water Pollutants, Chemical - pharmacology</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>0304-3894</issn><issn>1873-3336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1uEzEURi0EoqHwCCAv28UM_p3xrFAbCkGqYFPWlse-kzqasYM9iRregXfGJYEtla5k6ep895N8EHpLSU0Jbd5v6s29-TmZuWaEiprSmvD2GVpQ1fKKc948RwvCiai46sQZepXzhhBCWyleojMmRcNUIxfo103Y-xTDBGE243jACUbYmzBjG4Mty2RmH0PGccBrM5qHOHoH-GK1Wl5fYhMcnmMwx93V6u7rJfbB7Sw4HB-8K9k9_KHWEGD2FjszmTUUCH9M4HOGYPA2jocppu29eY1eDGbM8Ob0nqPvn27ulqvq9tvnL8ur28pKrubK0Yb0nHW9YlI5QaxRnPCOWCJUx8owotqhBdazrusbKfmgRNcoSVhvZMf5Obo43t2m-GMHedaTzxbG0QSIu6xp07adErShT0F5qRaUPQGVTHDBuCioPKI2xZwTDHqb_GTSQVOiH_3qjT751Y9-NaW6-C25d6eKXT-B-5f6K7QAH44AlO_be0g6Ww_FpPMJ7Kxd9P-p-A20NLg4</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Parolini, Marco</creator><creator>Magni, Stefano</creator><creator>Traversi, Irene</creator><creator>Villa, Sara</creator><creator>Finizio, Antonio</creator><creator>Binelli, Andrea</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QH</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>7QQ</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope></search><sort><creationdate>20150301</creationdate><title>Environmentally relevant concentrations of galaxolide (HHCB) and tonalide (AHTN) induced oxidative and genetic damage in Dreissena polymorpha</title><author>Parolini, Marco ; Magni, Stefano ; Traversi, Irene ; Villa, Sara ; Finizio, Antonio ; Binelli, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-d160b329b8258d40ca830390c048928922087f7e2b299b6553f84968502ba5933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Benzopyrans - analysis</topic><topic>Benzopyrans - pharmacology</topic><topic>Benzopyrans - toxicity</topic><topic>Carbonyls</topic><topic>Damage</topic><topic>Deoxyribonucleic acid</topic><topic>DNA Damage</topic><topic>Dreissena - drug effects</topic><topic>Dreissena - metabolism</topic><topic>Dreissena polymorpha</topic><topic>Ecosystems</topic><topic>Exposure</topic><topic>Galaxolide (HHCB)</topic><topic>Genetics</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Musk</topic><topic>Oxidative and genetic damage</topic><topic>Oxidative Stress - drug effects</topic><topic>Perfume - analysis</topic><topic>Perfume - pharmacology</topic><topic>Perfume - toxicity</topic><topic>Protein Carbonylation</topic><topic>Proteins</topic><topic>Stress concentration</topic><topic>Tetrahydronaphthalenes - analysis</topic><topic>Tetrahydronaphthalenes - pharmacology</topic><topic>Tetrahydronaphthalenes - toxicity</topic><topic>The exposure to environmental concentrations of galaxolide (HHCB) and tonalide (AHTN) induced significant oxidative and genetic damage to the zebra mussel</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Tonalide (AHTN)</topic><topic>Water Pollutants, Chemical - analysis</topic><topic>Water Pollutants, Chemical - pharmacology</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parolini, Marco</creatorcontrib><creatorcontrib>Magni, Stefano</creatorcontrib><creatorcontrib>Traversi, Irene</creatorcontrib><creatorcontrib>Villa, Sara</creatorcontrib><creatorcontrib>Finizio, Antonio</creatorcontrib><creatorcontrib>Binelli, Andrea</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Pollution Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Ceramic Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><jtitle>Journal of hazardous materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parolini, Marco</au><au>Magni, Stefano</au><au>Traversi, Irene</au><au>Villa, Sara</au><au>Finizio, Antonio</au><au>Binelli, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmentally relevant concentrations of galaxolide (HHCB) and tonalide (AHTN) induced oxidative and genetic damage in Dreissena polymorpha</atitle><jtitle>Journal of hazardous materials</jtitle><addtitle>J Hazard Mater</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>285</volume><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>0304-3894</issn><eissn>1873-3336</eissn><abstract>•Galaxolide (HHCB) and tonalide (AHTN) are emerging aquatic pollutans.•HHCB and AHTN hazard to non-target aquatic organisms is largely unknown.•We measured HHCB- and AHTN-induced oxidative and genetic damage to the zebra mussel.•Environmental concentrations of both musks caused oxidative damage.•HHCB and AHTN induced DNA fragmentation but no fixed genetic damage.
Synthetic musk compounds (SMCs) are extensively used as fragrances in several personal care products and have been recognized as emerging aquatic pollutants. Among SMCs, galaxolide (HHCB) and tonalide (AHTN) are extensively used and have been measured in aquatic ecosystems worldwide. However, their potential risk to organisms remains largely unknown. The aim of this study was to investigate whether 21-day exposures to HHCB and AHTN concentrations frequently measured in aquatic ecosystems can induce oxidative and genetic damage in Dreissena polymorpha. The lipid peroxidation (LPO) and protein carbonyl content (PCC) were measured as oxidative stress indexes, while the DNA precipitation assay and the micronucleus test (MN test) were applied to investigate genetic injuries. HHCB induced significant increases in LPO and PCC levels, while AHTN enhanced only protein carbonylation. Moreover, significant increases in DNA strand breaks were caused by exposure to the highest concentrations of HHCB and AHTN tested in the present study, but no fixed genetic damage was observed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25462865</pmid><doi>10.1016/j.jhazmat.2014.11.037</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3894 |
| ispartof | Journal of hazardous materials, 2015-03, Vol.285, p.1-10 |
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| language | eng |
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| subjects | Animals Benzopyrans - analysis Benzopyrans - pharmacology Benzopyrans - toxicity Carbonyls Damage Deoxyribonucleic acid DNA Damage Dreissena - drug effects Dreissena - metabolism Dreissena polymorpha Ecosystems Exposure Galaxolide (HHCB) Genetics Lipid Peroxidation - drug effects Musk Oxidative and genetic damage Oxidative Stress - drug effects Perfume - analysis Perfume - pharmacology Perfume - toxicity Protein Carbonylation Proteins Stress concentration Tetrahydronaphthalenes - analysis Tetrahydronaphthalenes - pharmacology Tetrahydronaphthalenes - toxicity The exposure to environmental concentrations of galaxolide (HHCB) and tonalide (AHTN) induced significant oxidative and genetic damage to the zebra mussel Thiobarbituric Acid Reactive Substances - metabolism Tonalide (AHTN) Water Pollutants, Chemical - analysis Water Pollutants, Chemical - pharmacology Water Pollutants, Chemical - toxicity |
| title | Environmentally relevant concentrations of galaxolide (HHCB) and tonalide (AHTN) induced oxidative and genetic damage in Dreissena polymorpha |
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