Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)
Abstract Diagnosis of Alzheimer's disease (AD) can be performed with the assistance of amyloid imaging. The current method relies on positron emission tomography (PET), which is expensive and exposes people to radiation, undesirable features for a population screening method. Magnetic resonance...
Gespeichert in:
| Veröffentlicht in: | Biomaterials 2015-03, Vol.44, p.155-172 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 172 |
|---|---|
| container_issue | |
| container_start_page | 155 |
| container_title | Biomaterials |
| container_volume | 44 |
| creator | Cheng, Kwok Kin Chan, Pui Shan Fan, Shujuan Kwan, Siu Ming Yeung, King Lun Wáng, Yì-Xiáng J Chow, Albert Hee Lum Wu, Ed X Baum, Larry |
| description | Abstract Diagnosis of Alzheimer's disease (AD) can be performed with the assistance of amyloid imaging. The current method relies on positron emission tomography (PET), which is expensive and exposes people to radiation, undesirable features for a population screening method. Magnetic resonance imaging (MRI) is cheaper and is not radioactive. Our approach uses magnetic nanoparticles (MNPs) made of superparamagnetic iron oxide (SPIO) conjugated with curcumin, a natural compound that specifically binds to amyloid plaques. Coating of curcumin-conjugated MNPs with polyethylene glycol-polylactic acid block copolymer and polyvinylpyrrolidone by antisolvent precipitation in a multi-inlet vortex mixer produces stable and biocompatible curcumin magnetic nanoparticles (Cur-MNPs) with mean diameter |
| doi_str_mv | 10.1016/j.biomaterials.2014.12.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1677984054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0142961214012496</els_id><sourcerecordid>1652435137</sourcerecordid><originalsourceid>FETCH-LOGICAL-c567t-94aface304c9e3cc368cbee51fcfbd121c9cf19f598e08373cae0608bb8379cd3</originalsourceid><addsrcrecordid>eNqNUsuO1DAQtBCInR34BWRxYfeQ4EecxByQVsNrpUVIPM6W0-kMHpJ41k6Qhl_gp3E0ywpxmpPd7qrqdlcT8pyznDNevtzljfODnTA428dcMF7kXOSMqQdkxeuqzpRm6iFZpYTIdMnFGTmPccdSzArxmJwJVfKKS7UivzdzgHlwYwZ-3M3bpNrSwW5HnBzQ0Y5-b0O69hhp5wNtcUKY3Lildjj03rV039vbOWXdSK_6X9_RDRheRNq6iDYiHRwgnePCuJcNGH2STgmX3pbUxcfP15dPyKMufQif3p1r8u3d26-bD9nNp_fXm6ubDFRZTZkubGcBJStAowSQZQ0NouIddE3LBQcNHded0jWyWlYSLLKS1U2TAg2tXJOLo-4--KX1yQwuAva9HdHP0fCyqnRdMFWcApWyFlyJE6BKFFLx1NCavDpCIfgYA3ZmH9IkwsFwZhaLzc78a7FZLDZcmGRxIj-7qzM3A7b31L-eJsCbIwDTDH86DCaCwzTt1oXknWm9O63O6_9koHejA9v_wAPGnZ_DuHC4iYlgvizLtuxa2jEuCl3KPxnY1h0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652435137</pqid></control><display><type>article</type><title>Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Cheng, Kwok Kin ; Chan, Pui Shan ; Fan, Shujuan ; Kwan, Siu Ming ; Yeung, King Lun ; Wáng, Yì-Xiáng J ; Chow, Albert Hee Lum ; Wu, Ed X ; Baum, Larry</creator><creatorcontrib>Cheng, Kwok Kin ; Chan, Pui Shan ; Fan, Shujuan ; Kwan, Siu Ming ; Yeung, King Lun ; Wáng, Yì-Xiáng J ; Chow, Albert Hee Lum ; Wu, Ed X ; Baum, Larry</creatorcontrib><description>Abstract Diagnosis of Alzheimer's disease (AD) can be performed with the assistance of amyloid imaging. The current method relies on positron emission tomography (PET), which is expensive and exposes people to radiation, undesirable features for a population screening method. Magnetic resonance imaging (MRI) is cheaper and is not radioactive. Our approach uses magnetic nanoparticles (MNPs) made of superparamagnetic iron oxide (SPIO) conjugated with curcumin, a natural compound that specifically binds to amyloid plaques. Coating of curcumin-conjugated MNPs with polyethylene glycol-polylactic acid block copolymer and polyvinylpyrrolidone by antisolvent precipitation in a multi-inlet vortex mixer produces stable and biocompatible curcumin magnetic nanoparticles (Cur-MNPs) with mean diameter <100 nm. These nanoparticles were visualized by transmission electron microscopy and atomic force microscopy, and their structure and chemistry were further characterized by X-ray diffraction, thermogravimetric analysis, X-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, and Fourier transform infrared spectroscopy. Cur-MNPs exhibited no cytotoxicity in either Madin–Darby canine kidney (MDCK) or differentiated human neuroblastoma cells (SH-SY5Y). The Papp of Cur-MNPs was 1.03 × 10−6 cm/s in an in vitro blood–brain barrier (BBB) model. Amyloid plaques could be visualized in ex vivo T2*-weighted magnetic resonance imaging (MRI) of Tg2576 mouse brains after injection of Cur–MNPs, and no plaques could be found in non-transgenic mice. Immunohistochemical examination of the mouse brains revealed that Cur-MNPs were co-localized with amyloid plaques. Thus, Cur–MNPs have the potential for non-invasive diagnosis of AD using MRI.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2014.12.005</identifier><identifier>PMID: 25617135</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adsorption ; Advanced Basic Science ; Alzheimer Disease - complications ; Alzheimer Disease - diagnosis ; Alzheimer's disease ; Amyloid plaques ; Animals ; Brain ; Cell Line, Tumor ; Cell Membrane Permeability - drug effects ; Curcumin ; Curcumin - chemistry ; Dentistry ; Diagnosis ; Disease Models, Animal ; Dogs ; Humans ; Immunohistochemistry ; Iron oxide nanoparticles ; Madin Darby Canine Kidney Cells ; Magnetic Resonance Imaging ; Magnetite Nanoparticles - ultrastructure ; Mice ; Mice, Transgenic ; MRI ; Nanoparticles ; Particle Size ; Photoelectron Spectroscopy ; Plaque, Amyloid - complications ; Plaque, Amyloid - diagnosis ; Polyethylene Glycols - chemistry ; Positron emission ; Spectrometry, Mass, Secondary Ion ; Spectroscopy, Fourier Transform Infrared ; Tg2576 mice ; Thermogravimetry ; Tomography ; X-Ray Diffraction ; X-rays</subject><ispartof>Biomaterials, 2015-03, Vol.44, p.155-172</ispartof><rights>Elsevier Ltd</rights><rights>2014 Elsevier Ltd</rights><rights>Copyright © 2014 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-94aface304c9e3cc368cbee51fcfbd121c9cf19f598e08373cae0608bb8379cd3</citedby><cites>FETCH-LOGICAL-c567t-94aface304c9e3cc368cbee51fcfbd121c9cf19f598e08373cae0608bb8379cd3</cites><orcidid>0000-0002-5345-9355</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biomaterials.2014.12.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25617135$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Kwok Kin</creatorcontrib><creatorcontrib>Chan, Pui Shan</creatorcontrib><creatorcontrib>Fan, Shujuan</creatorcontrib><creatorcontrib>Kwan, Siu Ming</creatorcontrib><creatorcontrib>Yeung, King Lun</creatorcontrib><creatorcontrib>Wáng, Yì-Xiáng J</creatorcontrib><creatorcontrib>Chow, Albert Hee Lum</creatorcontrib><creatorcontrib>Wu, Ed X</creatorcontrib><creatorcontrib>Baum, Larry</creatorcontrib><title>Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Abstract Diagnosis of Alzheimer's disease (AD) can be performed with the assistance of amyloid imaging. The current method relies on positron emission tomography (PET), which is expensive and exposes people to radiation, undesirable features for a population screening method. Magnetic resonance imaging (MRI) is cheaper and is not radioactive. Our approach uses magnetic nanoparticles (MNPs) made of superparamagnetic iron oxide (SPIO) conjugated with curcumin, a natural compound that specifically binds to amyloid plaques. Coating of curcumin-conjugated MNPs with polyethylene glycol-polylactic acid block copolymer and polyvinylpyrrolidone by antisolvent precipitation in a multi-inlet vortex mixer produces stable and biocompatible curcumin magnetic nanoparticles (Cur-MNPs) with mean diameter <100 nm. These nanoparticles were visualized by transmission electron microscopy and atomic force microscopy, and their structure and chemistry were further characterized by X-ray diffraction, thermogravimetric analysis, X-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, and Fourier transform infrared spectroscopy. Cur-MNPs exhibited no cytotoxicity in either Madin–Darby canine kidney (MDCK) or differentiated human neuroblastoma cells (SH-SY5Y). The Papp of Cur-MNPs was 1.03 × 10−6 cm/s in an in vitro blood–brain barrier (BBB) model. Amyloid plaques could be visualized in ex vivo T2*-weighted magnetic resonance imaging (MRI) of Tg2576 mouse brains after injection of Cur–MNPs, and no plaques could be found in non-transgenic mice. Immunohistochemical examination of the mouse brains revealed that Cur-MNPs were co-localized with amyloid plaques. Thus, Cur–MNPs have the potential for non-invasive diagnosis of AD using MRI.</description><subject>Adsorption</subject><subject>Advanced Basic Science</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease</subject><subject>Amyloid plaques</subject><subject>Animals</subject><subject>Brain</subject><subject>Cell Line, Tumor</subject><subject>Cell Membrane Permeability - drug effects</subject><subject>Curcumin</subject><subject>Curcumin - chemistry</subject><subject>Dentistry</subject><subject>Diagnosis</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Iron oxide nanoparticles</subject><subject>Madin Darby Canine Kidney Cells</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetite Nanoparticles - ultrastructure</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>MRI</subject><subject>Nanoparticles</subject><subject>Particle Size</subject><subject>Photoelectron Spectroscopy</subject><subject>Plaque, Amyloid - complications</subject><subject>Plaque, Amyloid - diagnosis</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Positron emission</subject><subject>Spectrometry, Mass, Secondary Ion</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Tg2576 mice</subject><subject>Thermogravimetry</subject><subject>Tomography</subject><subject>X-Ray Diffraction</subject><subject>X-rays</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsuO1DAQtBCInR34BWRxYfeQ4EecxByQVsNrpUVIPM6W0-kMHpJ41k6Qhl_gp3E0ywpxmpPd7qrqdlcT8pyznDNevtzljfODnTA428dcMF7kXOSMqQdkxeuqzpRm6iFZpYTIdMnFGTmPccdSzArxmJwJVfKKS7UivzdzgHlwYwZ-3M3bpNrSwW5HnBzQ0Y5-b0O69hhp5wNtcUKY3Lildjj03rV039vbOWXdSK_6X9_RDRheRNq6iDYiHRwgnePCuJcNGH2STgmX3pbUxcfP15dPyKMufQif3p1r8u3d26-bD9nNp_fXm6ubDFRZTZkubGcBJStAowSQZQ0NouIddE3LBQcNHded0jWyWlYSLLKS1U2TAg2tXJOLo-4--KX1yQwuAva9HdHP0fCyqnRdMFWcApWyFlyJE6BKFFLx1NCavDpCIfgYA3ZmH9IkwsFwZhaLzc78a7FZLDZcmGRxIj-7qzM3A7b31L-eJsCbIwDTDH86DCaCwzTt1oXknWm9O63O6_9koHejA9v_wAPGnZ_DuHC4iYlgvizLtuxa2jEuCl3KPxnY1h0</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Cheng, Kwok Kin</creator><creator>Chan, Pui Shan</creator><creator>Fan, Shujuan</creator><creator>Kwan, Siu Ming</creator><creator>Yeung, King Lun</creator><creator>Wáng, Yì-Xiáng J</creator><creator>Chow, Albert Hee Lum</creator><creator>Wu, Ed X</creator><creator>Baum, Larry</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SC</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><orcidid>https://orcid.org/0000-0002-5345-9355</orcidid></search><sort><creationdate>20150301</creationdate><title>Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)</title><author>Cheng, Kwok Kin ; Chan, Pui Shan ; Fan, Shujuan ; Kwan, Siu Ming ; Yeung, King Lun ; Wáng, Yì-Xiáng J ; Chow, Albert Hee Lum ; Wu, Ed X ; Baum, Larry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-94aface304c9e3cc368cbee51fcfbd121c9cf19f598e08373cae0608bb8379cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adsorption</topic><topic>Advanced Basic Science</topic><topic>Alzheimer Disease - complications</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer's disease</topic><topic>Amyloid plaques</topic><topic>Animals</topic><topic>Brain</topic><topic>Cell Line, Tumor</topic><topic>Cell Membrane Permeability - drug effects</topic><topic>Curcumin</topic><topic>Curcumin - chemistry</topic><topic>Dentistry</topic><topic>Diagnosis</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Iron oxide nanoparticles</topic><topic>Madin Darby Canine Kidney Cells</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetite Nanoparticles - ultrastructure</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>MRI</topic><topic>Nanoparticles</topic><topic>Particle Size</topic><topic>Photoelectron Spectroscopy</topic><topic>Plaque, Amyloid - complications</topic><topic>Plaque, Amyloid - diagnosis</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Positron emission</topic><topic>Spectrometry, Mass, Secondary Ion</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Tg2576 mice</topic><topic>Thermogravimetry</topic><topic>Tomography</topic><topic>X-Ray Diffraction</topic><topic>X-rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Kwok Kin</creatorcontrib><creatorcontrib>Chan, Pui Shan</creatorcontrib><creatorcontrib>Fan, Shujuan</creatorcontrib><creatorcontrib>Kwan, Siu Ming</creatorcontrib><creatorcontrib>Yeung, King Lun</creatorcontrib><creatorcontrib>Wáng, Yì-Xiáng J</creatorcontrib><creatorcontrib>Chow, Albert Hee Lum</creatorcontrib><creatorcontrib>Wu, Ed X</creatorcontrib><creatorcontrib>Baum, Larry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Kwok Kin</au><au>Chan, Pui Shan</au><au>Fan, Shujuan</au><au>Kwan, Siu Ming</au><au>Yeung, King Lun</au><au>Wáng, Yì-Xiáng J</au><au>Chow, Albert Hee Lum</au><au>Wu, Ed X</au><au>Baum, Larry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI)</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>44</volume><spage>155</spage><epage>172</epage><pages>155-172</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Abstract Diagnosis of Alzheimer's disease (AD) can be performed with the assistance of amyloid imaging. The current method relies on positron emission tomography (PET), which is expensive and exposes people to radiation, undesirable features for a population screening method. Magnetic resonance imaging (MRI) is cheaper and is not radioactive. Our approach uses magnetic nanoparticles (MNPs) made of superparamagnetic iron oxide (SPIO) conjugated with curcumin, a natural compound that specifically binds to amyloid plaques. Coating of curcumin-conjugated MNPs with polyethylene glycol-polylactic acid block copolymer and polyvinylpyrrolidone by antisolvent precipitation in a multi-inlet vortex mixer produces stable and biocompatible curcumin magnetic nanoparticles (Cur-MNPs) with mean diameter <100 nm. These nanoparticles were visualized by transmission electron microscopy and atomic force microscopy, and their structure and chemistry were further characterized by X-ray diffraction, thermogravimetric analysis, X-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, and Fourier transform infrared spectroscopy. Cur-MNPs exhibited no cytotoxicity in either Madin–Darby canine kidney (MDCK) or differentiated human neuroblastoma cells (SH-SY5Y). The Papp of Cur-MNPs was 1.03 × 10−6 cm/s in an in vitro blood–brain barrier (BBB) model. Amyloid plaques could be visualized in ex vivo T2*-weighted magnetic resonance imaging (MRI) of Tg2576 mouse brains after injection of Cur–MNPs, and no plaques could be found in non-transgenic mice. Immunohistochemical examination of the mouse brains revealed that Cur-MNPs were co-localized with amyloid plaques. Thus, Cur–MNPs have the potential for non-invasive diagnosis of AD using MRI.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>25617135</pmid><doi>10.1016/j.biomaterials.2014.12.005</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-5345-9355</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2015-03, Vol.44, p.155-172 |
| issn | 0142-9612 1878-5905 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1677984054 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adsorption Advanced Basic Science Alzheimer Disease - complications Alzheimer Disease - diagnosis Alzheimer's disease Amyloid plaques Animals Brain Cell Line, Tumor Cell Membrane Permeability - drug effects Curcumin Curcumin - chemistry Dentistry Diagnosis Disease Models, Animal Dogs Humans Immunohistochemistry Iron oxide nanoparticles Madin Darby Canine Kidney Cells Magnetic Resonance Imaging Magnetite Nanoparticles - ultrastructure Mice Mice, Transgenic MRI Nanoparticles Particle Size Photoelectron Spectroscopy Plaque, Amyloid - complications Plaque, Amyloid - diagnosis Polyethylene Glycols - chemistry Positron emission Spectrometry, Mass, Secondary Ion Spectroscopy, Fourier Transform Infrared Tg2576 mice Thermogravimetry Tomography X-Ray Diffraction X-rays |
| title | Curcumin-conjugated magnetic nanoparticles for detecting amyloid plaques in Alzheimer's disease mice using magnetic resonance imaging (MRI) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T03%3A17%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Curcumin-conjugated%20magnetic%20nanoparticles%20for%20detecting%20amyloid%20plaques%20in%20Alzheimer's%20disease%20mice%20using%20magnetic%20resonance%20imaging%20(MRI)&rft.jtitle=Biomaterials&rft.au=Cheng,%20Kwok%20Kin&rft.date=2015-03-01&rft.volume=44&rft.spage=155&rft.epage=172&rft.pages=155-172&rft.issn=0142-9612&rft.eissn=1878-5905&rft_id=info:doi/10.1016/j.biomaterials.2014.12.005&rft_dat=%3Cproquest_cross%3E1652435137%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652435137&rft_id=info:pmid/25617135&rft_els_id=S0142961214012496&rfr_iscdi=true |