Multiobjective optimization strategy based on desirability functions used for the microemulsion liquid chromatographic separation and quantification of norfloxacin and tinidazole in plasma and formulations

The aim of the present study was to optimize a microemulsion liquid chromatography method for the simultaneous determination of norfloxacin and tinidazole binary mixture using a chemometric protocol. Optimization experiments were conducted through a process of screening and optimization. A 27‐4 frac...

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Veröffentlicht in:	Journal of separation science 2015-03, Vol.38 (6), p.901-908
Hauptverfasser:	Abou-Taleb, Noura Hemdan, El-Wasseef, Dalia Rashad, El-Sherbiny, Dina Tawfik, El-Ashry, Saadia Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - blood Anti-Bacterial Agents - chemistry Antibiotics Chemometrics Chromatography Chromatography, High Pressure Liquid - methods Derringer's desirability function Emulsions - chemistry Fractional factorial design Humans Liquid chromatography Microemulsion liquid chromatography Microemulsions Norfloxacin Norfloxacin - blood Norfloxacin - chemistry Optimization Pharmacology Plasma - chemistry Screening Separation Tinidazole Tinidazole - blood Tinidazole - chemistry Triethylamine
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