Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation

ABSTRACT Fetal alcohol spectrum disorder (FASD) is a set of developmental malformations caused by excess alcohol consumption during pregnancy. Using an in vitro system, we examined the role that chronic ethanol (EtOH) exposure plays in gene expression changes during the early stage of embryonic diff...

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Veröffentlicht in:	Journal of applied toxicology 2014-01, Vol.34 (1), p.66-75
Hauptverfasser:	Halder, Debasish, Park, Ji Hyun, Choi, Mi Ran, Chai, Jin Choul, Lee, Young Seek, Mandal, Chanchal, Jung, Kyoung Hwa, Chai, Young Gyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohols Cancer Cell Cycle - drug effects Cell Differentiation - drug effects Cells, Cultured Cluster Analysis Deregulation Differentiation Down-Regulation embryoid body Embryology Embryonic Development - drug effects Ethanol Ethanol - adverse effects Ethyl alcohol Female Fetal Alcohol Spectrum Disorders - genetics folic acid Gene expression Gene Expression - drug effects Gene Expression Profiling Genes Goosecoid Protein - genetics Goosecoid Protein - metabolism GSC Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Microarray Analysis Nanog Homeobox Protein Nanostructure nodal signaling Octamer Transcription Factor-3 - genetics Octamer Transcription Factor-3 - metabolism Placenta - drug effects Pregnancy Reproducibility of Results Signal Transduction Toxicity transcriptomic
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